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• Responsible Curator: Bernard Henrissat

GH60 is a deleted family

Subsequent to family creation, it was shown that the actual activity was not glycosidic bond hydrolysis, as initially suggested.

Detailed sequence analyses show that the sequences in fact belong to metallopeptidase family M42. Evidence for peptidase activity was experimentally demonstrated by Cottrell et al. [1].

Reference

1. Cottrell MT, Yu L, and Kirchman DL. Sequence and expression analyses of Cytophaga-like hydrolases in a Western arctic metagenomic library and the Sargasso Sea. Appl Environ Microbiol 2005 Dec; 71(12) 8506-13. doi:10.1128/AEM.71.12.8506-8513.2005 pmid:16332841. PubMed HubMed [Cottrell2005]

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