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User:Florence Vincent

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From 1998 to 2001, I did my PhD in the group of Christian Cambillau in Marseille working on the structure-function relationships of several mammalian odorant binding proteins (OBPs). In January 2002 I joined the group of Gideon Davies in the YSBL laboratory as a postdoctoral fellow to study various carbohydrate esterases and their role in bacterial cell wall formation and breakdown. We worked on family CE7 [1], CE9 [2], and also GH5 [3] as well as other carbohydrate active enzymes like NagA [4] from Bacillus subtilis a N-acetylglucosamine-6-phophate deacetylase and NagB [5] a glucosamine-6-phosphate deaminase.

I returned to Marseille in 2004 to join the group of structural glycobiology directed by Yves Bourne at the AFMB laboratory in CNRS. Since then I’ve been interested in a GH73; an isoprenoid binding module appended to a CBM2 [6] and possibly involved in oxydoreduction events during plant cell wall breakdown; two putative carbohydrate binding domain appended to two global regulators [7] as well as several GT2 and GT4, all involved in biofilm formation in Pseudomonas aeruginosa.



  1. Vincent F, Charnock SJ, Verschueren KH, Turkenburg JP, Scott DJ, Offen WA, Roberts S, Pell G, Gilbert HJ, Davies GJ, and Brannigan JA. Multifunctional xylooligosaccharide/cephalosporin C deacetylase revealed by the hexameric structure of the Bacillus subtilis enzyme at 1.9A resolution. J Mol Biol. 2003 Jul 11;330(3):593-606. PubMed ID:12842474 | HubMed [Vincent2003]
  2. Taylor EJ, Gloster TM, Turkenburg JP, Vincent F, Brzozowski AM, Dupont C, Shareck F, Centeno MS, Prates JA, Puchart V, Ferreira LM, Fontes CM, Biely P, and Davies GJ. Structure and activity of two metal ion-dependent acetylxylan esterases involved in plant cell wall degradation reveals a close similarity to peptidoglycan deacetylases. J Biol Chem. 2006 Apr 21;281(16):10968-75. DOI:10.1074/jbc.M513066200 | PubMed ID:16431911 | HubMed [Taylor2006]
  3. Dias FM, Vincent F, Pell G, Prates JA, Centeno MS, Tailford LE, Ferreira LM, Fontes CM, Davies GJ, and Gilbert HJ. Insights into the molecular determinants of substrate specificity in glycoside hydrolase family 5 revealed by the crystal structure and kinetics of Cellvibrio mixtus mannosidase 5A. J Biol Chem. 2004 Jun 11;279(24):25517-26. DOI:10.1074/jbc.M401647200 | PubMed ID:15014076 | HubMed [Dias2004]
  4. Vincent F, Yates D, Garman E, Davies GJ, and Brannigan JA. The three-dimensional structure of the N-acetylglucosamine-6-phosphate deacetylase, NagA, from Bacillus subtilis: a member of the urease superfamily. J Biol Chem. 2004 Jan 23;279(4):2809-16. DOI:10.1074/jbc.M310165200 | PubMed ID:14557261 | HubMed [Vincent2004]
  5. Vincent F, Davies GJ, and Brannigan JA. Structure and kinetics of a monomeric glucosamine 6-phosphate deaminase: missing link of the NagB superfamily?. J Biol Chem. 2005 May 20;280(20):19649-55. DOI:10.1074/jbc.M502131200 | PubMed ID:15755726 | HubMed [Vincent2005]
  6. Vincent F, Molin DD, Weiner RM, Bourne Y, and Henrissat B. Structure of a polyisoprenoid binding domain from Saccharophagus degradans implicated in plant cell wall breakdown. FEBS Lett. 2010 Apr 16;584(8):1577-84. DOI:10.1016/j.febslet.2010.03.015 | PubMed ID:20227408 | HubMed [VincentFEBSLett2010]
  7. Vincent F, Round A, Reynaud A, Bordi C, Filloux A, and Bourne Y. Distinct oligomeric forms of the Pseudomonas aeruginosa RetS sensor domain modulate accessibility to the ligand binding site. Environ Microbiol. 2010 Jun;12(6):1775-86. DOI:10.1111/j.1462-2920.2010.02264.x | PubMed ID:20553556 | HubMed [VincentEnvironMicrobiol2010]
All Medline abstracts: PubMed | HubMed
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