Magali Remaud-Simeon graduated from the National Institute of Applied Science of Toulouse in 1985 and received her PhD in 1988. Then she was as Post-Doctoral Fellow at the University of Pensylvania, where she worked with Prof. D. Graves in the Department of Chemical and Biomolecular Engineering. From 1990 to 2000, she was an Associate Professor at the Institute of Technology of the University of Toulouse in the Department of Applied Biology. She joined the group Biocatalysis of Prof. P. Monsan at the "Laboratoire d'Ingénierie des Systèmes et des Procédés" in 1994. Since 2001, she is a Professor at the National Institute of Applied Science of Toulouse. At the head of the Enzyme Molecular Engineering and Catalysis group since 2001, she focuses her research activities on enzyme engineering for white biotechnology, green chemistry, Food/Feed industries, and synthetic biology. Her areas of interest cover enzyme structure/activity relationship studies, kinetic resolution, evolution combining both rational and combinatorial approaches, and applications to the synthesis of new polysaccharides, oligosaccharides, glyco-conjugates, esters, and enantiopure compounds. She has been working on glucansucrases from GH70 and GH13 since 1985. With her collaborators, she has investigated the mechanism of dextran, alternan and amylose biosynthesis by dextransucrase, alternansucrase and amylosucrase, respectively. Her work is currently focusing on the generation of enzymes displaying new specificities and improved properties towards unnatural substrates.
- André I, Potocki-Véronèse G, Morel S, Monsan P, and Remaud-Siméon M. Sucrose-utilizing transglucosidases for biocatalysis. Top Curr Chem. 2010;294:25-48.
- Fabre E, Bozonnet S, Arcache A, Willemot RM, Vignon M, Monsan P, and Remaud-Simeon M. Role of the two catalytic domains of DSR-E dextransucrase and their involvement in the formation of highly alpha-1,2 branched dextran. J Bacteriol. 2005 Jan;187(1):296-303. DOI:10.1128/JB.187.1.296-303.2005 |
- Moulis C, Joucla G, Harrison D, Fabre E, Potocki-Veronese G, Monsan P, and Remaud-Simeon M. Understanding the polymerization mechanism of glycoside-hydrolase family 70 glucansucrases. J Biol Chem. 2006 Oct 20;281(42):31254-67. DOI:10.1074/jbc.M604850200 |
- Brison Y, Pijning T, Malbert Y, Fabre É, Mourey L, Morel S, Potocki-Véronèse G, Monsan P, Tranier S, Remaud-Siméon M, and Dijkstra BW. Functional and structural characterization of α-(1->2) branching sucrase derived from DSR-E glucansucrase. J Biol Chem. 2012 Mar 9;287(11):7915-24. DOI:10.1074/jbc.M111.305078 |
- Guérin F, Barbe S, Pizzut-Serin S, Potocki-Véronèse G, Guieysse D, Guillet V, Monsan P, Mourey L, Remaud-Siméon M, André I, and Tranier S. Structural investigation of the thermostability and product specificity of amylosucrase from the bacterium Deinococcus geothermalis. J Biol Chem. 2012 Feb 24;287(9):6642-54. DOI:10.1074/jbc.M111.322917 |
- Champion E, André I, Moulis C, Boutet J, Descroix K, Morel S, Monsan P, Mulard LA, and Remaud-Siméon M. Design of alpha-transglucosidases of controlled specificity for programmed chemoenzymatic synthesis of antigenic oligosaccharides. J Am Chem Soc. 2009 Jun 3;131(21):7379-89. DOI:10.1021/ja900183h |
- Albenne C, Skov LK, Mirza O, Gajhede M, Feller G, D'Amico S, André G, Potocki-Véronèse G, van der Veen BA, Monsan P, and Remaud-Simeon M. Molecular basis of the amylose-like polymer formation catalyzed by Neisseria polysaccharea amylosucrase. J Biol Chem. 2004 Jan 2;279(1):726-34. DOI:10.1074/jbc.M309891200 |