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User:Nicole Koropatkin

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Nicole Koropatkin received her PhD in Biochemistry from the University of Wisconsin in 2004. Trained in structural enzymology in the lab of Hazel Holden, her graduate work focused on the enymes involved in O-antigen deoxysugar biosynthesis in Salmonella typhi. After finishing her training, she moved to the lab of Thomas Smith at the Donald Danforth Plant Science Center in St. Louis. She received an NRSA to determine the structural basis for nitrate and bicarbonate discrimination within the ABC transport systems of Synechocystis PCC 6803. After completing this study, she teamed up with Eric Martens from the Jeffrey Gordon lab at Washington University in St. Louis in order to investigate the structures of the novel proteins encoded within Bacteroidetes polysaccharide utilization loci. In 2009 she moved to the University of Michigan Medical School. She is currently an Assistant Professor in the Microbiology and Immunology department. The Koropatkin lab studies the structural biology of glycan capture by a variety of human gut bacteria.


Selected Citations

  1. Koropatkin NM, Martens EC, Gordon JI, and Smith TJ. Starch catabolism by a prominent human gut symbiont is directed by the recognition of amylose helices. Structure. 2008 Jul;16(7):1105-15. DOI:10.1016/j.str.2008.03.017 | PubMed ID:18611383 | HubMed [Koropatkin2009]
  2. Martens EC, Koropatkin NM, Smith TJ, and Gordon JI. Complex glycan catabolism by the human gut microbiota: the Bacteroidetes Sus-like paradigm. J Biol Chem. 2009 Sep 11;284(37):24673-7. DOI:10.1074/jbc.R109.022848 | PubMed ID:19553672 | HubMed [Martens2009]
  3. Koropatkin NM and Smith TJ. SusG: a unique cell-membrane-associated alpha-amylase from a prominent human gut symbiont targets complex starch molecules. Structure. 2010 Feb 10;18(2):200-15. DOI:10.1016/j.str.2009.12.010 | PubMed ID:20159465 | HubMed [Koropatkin2010]
  4. Cameron EA, Kwiatkowski KJ, Lee BH, Hamaker BR, Koropatkin NM, and Martens EC. Multifunctional nutrient-binding proteins adapt human symbiotic bacteria for glycan competition in the gut by separately promoting enhanced sensing and catalysis. MBio. 2014 Sep 9;5(5):e01441-14. DOI:10.1128/mBio.01441-14 | PubMed ID:25205092 | HubMed [Cameron2014]
  5. Karunatilaka KS, Cameron EA, Martens EC, Koropatkin NM, and Biteen JS. Superresolution imaging captures carbohydrate utilization dynamics in human gut symbionts. MBio. 2014 Nov 11;5(6):e02172. DOI:10.1128/mBio.02172-14 | PubMed ID:25389179 | HubMed [Karunatilaka2014]
  6. Cockburn DW, Orlovsky NI, Foley MH, Kwiatkowski KJ, Bahr CM, Maynard M, Demeler B, and Koropatkin NM. Molecular details of a starch utilization pathway in the human gut symbiont Eubacterium rectale. Mol Microbiol. 2015 Jan;95(2):209-30. DOI:10.1111/mmi.12859 | PubMed ID:25388295 | HubMed [Cockburn2015]
  7. Foley MH, Cockburn DW, and Koropatkin NM. The Sus operon: a model system for starch uptake by the human gut Bacteroidetes. Cell Mol Life Sci. 2016 Jul;73(14):2603-17. DOI:10.1007/s00018-016-2242-x | PubMed ID:27137179 | HubMed [Foley2016]
  8. Tauzin AS, Kwiatkowski KJ, Orlovsky NI, Smith CJ, Creagh AL, Haynes CA, Wawrzak Z, Brumer H, and Koropatkin NM. Molecular Dissection of Xyloglucan Recognition in a Prominent Human Gut Symbiont. MBio. 2016 Apr 26;7(2):e02134-15. DOI:10.1128/mBio.02134-15 | PubMed ID:27118585 | HubMed [Tauzin2016]
  9. Larsbrink J, Zhu Y, Kharade SS, Kwiatkowski KJ, Eijsink VG, Koropatkin NM, McBride MJ, and Pope PB. A polysaccharide utilization locus from Flavobacterium johnsoniae enables conversion of recalcitrant chitin. Biotechnol Biofuels. 2016;9:260. DOI:10.1186/s13068-016-0674-z | PubMed ID:27933102 | HubMed [Larsbrink2016]
  10. Cockburn DW and Koropatkin NM. Polysaccharide Degradation by the Intestinal Microbiota and Its Influence on Human Health and Disease. J Mol Biol. 2016 Aug 14;428(16):3230-3252. DOI:10.1016/j.jmb.2016.06.021 | PubMed ID:27393306 | HubMed [Cockburn2016]
  11. Wefers D, Cavalcante JJV, Schendel RR, Deveryshetty J, Wang K, Wawrzak Z, Mackie RI, Koropatkin NM, and Cann I. Biochemical and Structural Analyses of Two Cryptic Esterases in Bacteroides intestinalis and their Synergistic Activities with Cognate Xylanases. J Mol Biol. 2017 Aug 4;429(16):2509-2527. DOI:10.1016/j.jmb.2017.06.017 | PubMed ID:28669823 | HubMed [Wefers2017]
All Medline abstracts: PubMed | HubMed
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