CAZypedia needs your help! We have many unassigned GH, PL, CE, AA, GT, and CBM pages in need of Authors and Responsible Curators.
Scientists at all career stages, including students, are welcome to contribute to CAZypedia. Read more here, and in the 10th anniversary article in Glycobiology.
New to the CAZy classification? Read this first.
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Consider attending the 15th Carbohydrate Bioengineering Meeting in Ghent, 5-8 May 2024.
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| − | '''18 December 2013:''' ''A new mannanase page:'' Today, '''[[User:Rohan Williams|Rohan Williams]]''' and '''[[User:Spencer Williams|Spencer Williams]]''' completed the '''[[Glycoside Hydrolase Family 113]]''' page. '''[[GH113]]''' is currently a very small family (120 members) with only one characterized member, the ''Alicyclobacillus acidocaldarius'' beta(1-4)-mannanase. The seminal crystal structure of this enzyme revealed '''[[GH113]]''' to be a member of [[Clan]] GH-A. A recent publication from the '''[[User:Spencer Williams|Williams]]''' and | + | '''18 December 2013:''' ''A new mannanase page:'' Today, '''[[User:Rohan Williams|Rohan Williams]]''' and '''[[User:Spencer Williams|Spencer Williams]]''' completed the '''[[Glycoside Hydrolase Family 113]]''' page. '''[[GH113]]''' is currently a very small family (120 members) with only one characterized member, the ''Alicyclobacillus acidocaldarius'' beta(1-4)-mannanase. The seminal crystal structure of this enzyme revealed '''[[GH113]]''' to be a member of [[Clan]] GH-A. A recent publication from the '''[[User:Spencer Williams|Williams]]''' team and collaborators illuminated further details of the '''[[GH113]]''' and '''[[GH26]]''' transition states using a designed inhibitor-enzyme complexes. ''Read more about this emerging family [[Glycoside Hydrolase Family 113|here]]!'' |
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'''New for fall 2013:''' ''The CAZy database [http://dx.doi.org/10.1093/nar/gkt1178 now presents enzyme ligands!]'' See any family's [http://www.cazy.org/GH5_structure.html "Structure" page] for examples. | '''New for fall 2013:''' ''The CAZy database [http://dx.doi.org/10.1093/nar/gkt1178 now presents enzyme ligands!]'' See any family's [http://www.cazy.org/GH5_structure.html "Structure" page] for examples. | ||
Revision as of 15:44, 18 December 2013
18 December 2013: A new mannanase page: Today, Rohan Williams and Spencer Williams completed the Glycoside Hydrolase Family 113 page. GH113 is currently a very small family (120 members) with only one characterized member, the Alicyclobacillus acidocaldarius beta(1-4)-mannanase. The seminal crystal structure of this enzyme revealed GH113 to be a member of Clan GH-A. A recent publication from the Williams team and collaborators illuminated further details of the GH113 and GH26 transition states using a designed inhibitor-enzyme complexes. Read more about this emerging family here!
New for fall 2013: The CAZy database now presents enzyme ligands! See any family's "Structure" page for examples.
6 October 2013: GH66 page upgraded to Curator Approved status: Today, Responsible Curator Zui Fujimoto formally approved the Glycoside Hydrolase Family 66 page, Authored by Ryuichiro Suzuki, as complete and ready for public viewing. GH66 is a very small family, currently containing ca. 60 members, of α(1-6)-glucan hydrolases (a.k.a. dextranases) and cyclo-isomalto-oligosaccharide glucanotransferases. Through a series of elegant studies including biochemical and crystallographic analyses, Dr. Fujimoto and his collaborators have provided direct insight into catalysis by this unique family. Read more about the long history of these enzymes here!
30 September 2013: Our first PL page!: Wade Abbott finalized CAZypedia's first Polysaccharide Lyase Family page, PL2, today. As with our recent foray into CBM families (see our May 22 news item) the extension of CAZypedia to include the PLs ushers in a new phase in our development, and we are very much looking forward to the evolution of this new group of pages, spearheaded by Wade Abbott and Michael Suits. If you are an expert on any of the 22 PL families in the CAZy Database and would like to contribute to CAZypedia, please contact us here.
19 September 2013: We are proud to announce the completion of CAZypedia's first Auxiliary Activity (AA) Family page! Paul Harris, one of the founding fathers of the family previously known as GH61, has composed a lucid summary of the history and state-of-the-art of Auxiliary Activity Family 9. The revelation that these enzymes are actually copper-dependent lytic polysaccharide mono-oxygenases (LPMO), and not classic cellulases as originally thought, is one of the most exciting discoveries in enzymatic biomass degradation in recent years. Read more about this fascinating class of enzymes on the here, and stay tuned for forthcoming page on the closely related AA10 family.
28 June 2013: CAZypedia was highlighted in a review article in Current Opinion in Structural Biology available online today. This review provides a succinct overview of some of the most exciting CAZyme structure-function studies in recent years, and we'd like to thank the authors, Shinya Fushinobu, Victor Alves, and Pedro Coutinho, for showcasing CAZypedia as well!