User:Glyn Hemsworth

Glyn Hemsworth obtained his B.Sc. in Biochemistry from the University of Sheffield where he stayed on to complete his PhD under the supervision of Prof. Peter Artymiuk, primarily focussing on the structural characterisation of an unusual Flap Endonuclease homologue from Escherichia coli. In 2009 he moved to the Structural Biology Laboratory at the University of York where he initially worked on dUTPases from Trypanosoma and Leishmania species with Prof Keith Wilson. In 2012 he moved into the carbohydrate field taking up his current post-doctoral position with Prof ^^^Gideon Davies^^^ where his major contributions have been in the structural and functional characterisation of lytic polysaccharide mono-oxygenases (LPMOs) [1] in families AA10 and the newly discovered AA11. He has determined the crystal structures of

• AA10 from Bacillus amyloliquefaciens [2]
• AA11 from Aspergillus oryzae [3]
• GH5 from Bacteroides ovatus [4]

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1. Hemsworth GR, Davies GJ, and Walton PH. (2013). Recent insights into copper-containing lytic polysaccharide mono-oxygenases. Curr Opin Struct Biol. 2013;23(5):660-8. DOI:10.1016/j.sbi.2013.05.006 |
2. Hemsworth GR, Taylor EJ, Kim RQ, Gregory RC, Lewis SJ, Turkenburg JP, Parkin A, Davies GJ, and Walton PH. (2013). The copper active site of CBM33 polysaccharide oxygenases. J Am Chem Soc. 2013;135(16):6069-77. DOI:10.1021/ja402106e |
3. Hemsworth GR, Henrissat B, Davies GJ, and Walton PH. (2014). Discovery and characterization of a new family of lytic polysaccharide monooxygenases. Nat Chem Biol. 2014;10(2):122-6. DOI:10.1038/nchembio.1417 |
4. Larsbrink J, Rogers TE, Hemsworth GR, McKee LS, Tauzin AS, Spadiut O, Klinter S, Pudlo NA, Urs K, Koropatkin NM, Creagh AL, Haynes CA, Kelly AG, Cederholm SN, Davies GJ, Martens EC, and Brumer H. (2014). A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes. Nature. 2014;506(7489):498-502. DOI:10.1038/nature12907 |