https://www.cazypedia.org/api.php?action=feedcontributions&feedformat=atom&user=Marie-Line+GarronCAZypedia - User contributions [en-ca]2026-04-30T13:36:23ZUser contributionsMediaWiki 1.35.10https://www.cazypedia.org/index.php?title=Polysaccharide_Lyase_Family_31&diff=18346Polysaccharide Lyase Family 312024-08-23T15:42:32Z<p>Marie-Line Garron: </p>
<hr />
<div><!-- RESPONSIBLE CURATORS: Please replace the {{UnderConstruction}} tag below with {{CuratorApproved}} when the page is ready for wider public consumption --><br />
{{CuratorApproved}}<br />
* [[Author]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
* [[Responsible Curator]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
----<br />
<br />
<!-- The data in the table below should be updated by the Author/Curator according to current information on the family --><br />
<div style="float:right"><br />
{| {{Prettytable}} <br />
|-<br />
|{{Hl2}} colspan="2" align="center" |'''Polysaccharide Lyase Family PL31'''<br />
|-<br />
|'''3D Structure''' <br />
|Right handed &beta;-helix<br />
|-<br />
|'''Mechanism''' <br />
|&beta;-elimination<br />
|-<br />
|'''Charge neutraliser'''<br />
|Divalent cation (based on docking)<br />
|-<br />
|'''Active site residues'''<br />
|Lysine (base) and Tyrosine (acid) (mutagenesis and docking)<br />
|-<br />
|{{Hl2}} colspan="2" align="center" |'''CAZy DB link'''<br />
|-<br />
| colspan="2" |{{CAZyDBlink}}PL31.html<br />
|}<br />
</div><br />
<!-- This is the end of the table --><br />
<br />
<br />
== Substrate specificities ==<br />
The PL31 family is mainly a bacterial family distantly related to the PL41 family ([http://www.cazy.org/PL31.html PL31]) <cite>Drula2022</cite>. The first activities were demonstrated against poly-glucuronan for ''Saccharophagus degradans 2-40'' (ABD82242.1) and ''Streptomyces hygroscopicus subsp. jinggangensis'' (AGF62897.1) ([https://www.enzyme-database.org/query.php?ec=4.2.2.14 EC 4.2.2.14]) <cite>Helbert2019</cite>. Shortly afterwards, another PL31 member with a different function was characterized. PsAly, from ''Paenibacillus sp. FPU-7'', is an endo-alginate lyase specific for polymannuronate ([https://www.enzyme-database.org/query.php?ec=4.2.2.3 EC 4.2.2.3]) <cite>Itoh2019</cite>. The poly-M specific alginate lyase function was confirmed by the characterization of paeh-aly, belonging to ''Paenibacillus ehimensis'' <cite>Wang2023</cite>. The two publications on poly-M alginate lyases also reported a significant increase in activity in the presence of divalent cations, mainly Mg<sup>2+</sup> <cite>Itoh2019 Wang2023</cite>. <br />
<br />
== Kinetics and Mechanism ==<br />
Like the other family of PLs, the PL31 family follows the same &beta;-elimination process, involving a neutralizer, a Brønstead base and an acid <cite>Garron2010</cite>. Based on the C5 and C4 orientation, there are two variations of the &beta;-elimination, the ''syn''-elimination, where the C4-oxygen of the glycosidic bond and the C5-abstracted proton are on the same side, and the inverse, the ''anti''-elimination <cite>Garron2010</cite>. Poly-glucuronan ([https://www.enzyme-database.org/query.php?ec=4.2.2.14 EC 4.2.2.14]) or poly-M specific alginate lyase ([https://www.enzyme-database.org/query.php?ec=4.2.2.3 EC 4.2.2.3]) require a ''syn''-elimination mechanism, in which case the Brønstead base and acid roles can be played, sometimes by the same amino acid. <br />
Several mutants of PsAly have been realized by Itoh and co-workers. Activity is completely lost for the Y184F and K221A mutants and greatly reduced when several charged amino acids in the catalytic pocket are mutated. To discriminate the exact role of Y184 and K221, and in the absence of structures with products or substrate, docking simulations were performed. Based on the docking, the authors hypothesis that K221 could be the Brønstead base and Y184 the Brønstead acid, while the carboxylate would be neutralized by a divalent cation <cite>Itoh2019</cite>.<br />
<br />
<br />
== Three-dimensional structures ==<br />
PL31 presents a right handed &beta;-helix fold, which is already found in several PL families such as PL1, 3 or the alginate family PL6 <cite>Huang1999</cite>. The only structure available has been solved at high resolution (0,89Å) ([https://www.rcsb.org/structure/6KFN PDB 6KFN]) and is composed of 10 &beta;-stand coils and one &alpha;-helix capping the N-terminus extremity <cite>Itoh2019</cite>. Despite the difference in function, the closest structural homologue is Pel9A, a pectate lyase of the PL9 family ([https://www.rcsb.org/structure/1RU4 PDB 1RU4])<cite>Itoh2019 Jenkins2004</cite>. The structure of PSAly was solved with 2 sodium ions in the catalityc cleft, identified by the authors on the basis of the structural homology. <br />
<br />
== Family Firsts ==<br />
;First desciption of catalytic activity: Glucuronan lyase was the first activity reported for the family PL31 <cite>Helbert2019</cite>.<br />
<br />
;First charge neutralizer identification: Based on the influence of cations on activity and the docking experiments, Itoh and co-workers hypothesised that divalent cations could be the neutralizer <cite>Itoh2019</cite>. <br />
<br />
;First Brønstead acid and base residue identification: The total loss of activity when PsAly is mutated on Y184 and K221, confirms their crucial role in catalysis. The base and acid functions were assigned on the basis of docking: Lys the base and Tyr the acid <cite>Itoh2019</cite>. <br />
<br />
;First 3-D structure: The structure of the poly-M specific alginate lyase, PSAly, was the first solved by X-ray diffraction at 0.89Å resolution ([https://www.rcsb.org/structure/6KFN PDB 6KFN]) <cite>Itoh2019</cite>.<br />
<br />
== References ==<br />
<biblio><br />
#Drula2022 pmid=18838391<br />
#Helbert2019 pmid=30850540<br />
#Itoh2019 pmid=31619701<br />
#Wang2023 pmid=36906979<br />
#Garron2010 pmid=20805221<br />
<br />
#Huang1999 pmid=10600383<br />
#Jenkins2004 pmid=14670977<br />
<br />
</biblio><br />
<br />
[[Category:Polysaccharide Lyase Families|PL031]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=Polysaccharide_Lyase_Family_34&diff=18345Polysaccharide Lyase Family 342024-08-23T15:32:36Z<p>Marie-Line Garron: </p>
<hr />
<div><!-- RESPONSIBLE CURATORS: Please replace the {{UnderConstruction}} tag below with {{CuratorApproved}} when the page is ready for wider public consumption --><br />
{{CuratorApproved}}<br />
* [[Author]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
* [[Responsible Curator]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
----<br />
<br />
<!-- The data in the table below should be updated by the Author/Curator according to current information on the family --><br />
<div style="float:right"><br />
{| {{Prettytable}} <br />
|-<br />
|{{Hl2}} colspan="2" align="center" |'''Polysaccharide Lyase Family PL33'''<br />
|-<br />
|'''3D Structure''' <br />
|<br />
|-<br />
|'''Mechanism''' <br />
|<br />
|-<br />
|'''Charge neutraliser'''<br />
|<br />
|-<br />
|'''Active site residues'''<br />
|<br />
|-<br />
|{{Hl2}} colspan="2" align="center" |'''CAZy DB link'''<br />
|-<br />
| colspan="2" |{{CAZyDBlink}}PL33.html<br />
|}<br />
</div><br />
<!-- This is the end of the table --><br />
<br />
<br />
== Substrate specificities ==<br />
PL34 is a small family (28 sequences), mainly bacterial, with only one sequence belonging to the metazoan ''Knipowitschia caucasica'' ([http://www.cazy.org/PL34.html PL34])<cite>Drula2022</cite>. The founding member of family 34, and the only one characterized, belongs to OPIT5_18480 of Opitutaceae bacterium TAV5 (AHF91913.1). This enzyme presents an activity against alginate (EC 4.2.2.-) <cite>Helbert2019</cite>.<br />
<br />
== Kinetics and Mechanism ==<br />
Not determined<br />
<br />
== Catalytic Residues ==<br />
Not determined<br />
<br />
== Three-dimensional structures ==<br />
Unsolved<br />
<br />
== Family Firsts ==<br />
;First description of catalytic activity: Alginate lyase was the first activity discovered for the family PL34 <cite>Helbert2019</cite>. <br />
;First First charge neutralizer identification: To be determined<br />
;First Brønstead acid and base residue identification: To be determined<br />
;First 3-D structure: To be determined<br />
<br />
== References ==<br />
<biblio><br />
#Drula2022 pmid=34850161 <br />
#Helbert2019 pmid=30850540 <br />
</biblio><br />
<br />
[[Category:Polysaccharide Lyase Families|PL034]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=Polysaccharide_Lyase_Family_30&diff=18344Polysaccharide Lyase Family 302024-08-23T15:31:52Z<p>Marie-Line Garron: </p>
<hr />
<div><!-- RESPONSIBLE CURATORS: Please replace the {{UnderConstruction}} tag below with {{CuratorApproved}} when the page is ready for wider public consumption --><br />
{{CuratorApproved}}<br />
* [[Author]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
* [[Responsible Curator]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
----<br />
<br />
<!-- The data in the table below should be updated by the Author/Curator according to current information on the family --><br />
<div style="float:right"><br />
{| {{Prettytable}} <br />
|-<br />
|{{Hl2}} colspan="2" align="center" |'''Polysaccharide Lyase Family PL30'''<br />
|-<br />
|'''3D Structure''' <br />
|<br />
|-<br />
|'''Mechanism''' <br />
|<br />
|-<br />
|'''Charge neutraliser'''<br />
|<br />
|-<br />
|'''Active site residues'''<br />
|<br />
|-<br />
|{{Hl2}} colspan="2" align="center" |'''CAZy DB link'''<br />
|-<br />
| colspan="2" |{{CAZyDBlink}}PL30.html<br />
|}<br />
</div><br />
<!-- This is the end of the table --><br />
<br />
<br />
== Substrate specificities ==<br />
PL30 is a small family (38 sequences), exclusively bacterial belonging to the phylum ''Bacteroidetes'' ([http://www.cazy.org/PL30.html PL30]) <cite>Drula2022</cite>. The founding member of family 30, and the only one characterized, belongs to ''Bacteroides cellulosilyticus WH2 (BcellWH2_02524, ''WP_029426181.1). The activity was measured against hyaluronic acid by following the absorbance at 232nm. The increase in absorbance confirms that ''BcellWH2_02524 ''is a hyaluronan lyase ([https://www.enzyme-database.org/query.php?ec=4.2.2.1 4.2.2.1]), probably using the by &beta;-elimination process like all PL families <cite>Helbert2019</cite>. <br />
<br />
== Kinetics and Mechanism ==<br />
Not Determined<br />
<br />
== Catalytic Residues ==<br />
Not Determined<br />
<br />
== Three-dimensional structures ==<br />
Unsolved<br />
<br />
== Family Firsts ==<br />
;First description of catalytic activity: Hyaluronan lyase was the first activity discovered for the family PL30 <cite>Helbert2019</cite>.<br />
;First charge neutralizer identification: To be determined<br />
;First Brønstead acid and base residue identification: To be determinated<br />
;First 3-D structure: To be determinated<br />
<br />
== References ==<br />
<biblio><br />
<br />
#Drula2022 pmid=34850161<br />
<br />
#Helbert2019 pmid=30850540<br />
</biblio><br />
<br />
[[Category:Polysaccharide Lyase Families|PL030]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=Polysaccharide_Lyase_Family_32&diff=18343Polysaccharide Lyase Family 322024-08-23T15:31:23Z<p>Marie-Line Garron: </p>
<hr />
<div><!-- RESPONSIBLE CURATORS: Please replace the {{UnderConstruction}} tag below with {{CuratorApproved}} when the page is ready for wider public consumption --><br />
{{CuratorApproved}} <br />
* [[Author]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
* [[Responsible Curator]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
----<br />
<br />
<br />
== Substrate specificities ==<br />
The PL32 family was created following the functional characterization of the ORF “HMPREF1071_02769” from ''Bacteroides salyersiae ''CL02T12C01 (EIY62149.1), which showed endo-mannuronan lyase activity ([https://www.enzyme-database.org/query.php?ec=4.2.2.3 EC 4.2.2.3]) <cite>Helbert2019</cite>. Shortly afterwards, the sequence was <u>'''reclassified'''</u> as [http://www.cazy.org/PL0.html PL_nc] on the basis of structural modelling revealing that the catalytic domain was restricted to the N-terminal domain <cite>Drula2022</cite>. The small number of sequences and the proximity to the PL14 and PL36 families do not allow the creation of a new PL family. <br />
<br />
== References ==<br />
<biblio><br />
#Helbert2019 pmid=30850540<br />
<br />
#Drula2022 pmid=34850161<br />
<br />
</biblio><br />
<br />
[[Category:Polysaccharide Lyase Families|PL032]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=Polysaccharide_Lyase_Family_32&diff=18342Polysaccharide Lyase Family 322024-08-23T15:30:18Z<p>Marie-Line Garron: </p>
<hr />
<div><!-- RESPONSIBLE CURATORS: Please replace the {{UnderConstruction}} tag below with {{CuratorApproved}} when the page is ready for wider public consumption --><br />
{{UnderConstruction}}<br />
* [[Author]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
* [[Responsible Curator]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
----<br />
<br />
<br />
== Substrate specificities ==<br />
The PL32 family was created following the functional characterization of the ORF “HMPREF1071_02769” from ''Bacteroides salyersiae ''CL02T12C01 (EIY62149.1), which showed endo-mannuronan lyase activity ([https://www.enzyme-database.org/query.php?ec=4.2.2.3 EC 4.2.2.3]) <cite>Helbert2019</cite>. Shortly afterwards, the sequence was <u>'''reclassified'''</u> as [http://www.cazy.org/PL0.html PL_nc] on the basis of structural modelling revealing that the catalytic domain was restricted to the N-terminal domain <cite>Drula2022</cite>. The small number of sequences and the proximity to the PL14 and PL36 families do not allow the creation of a new PL family. <br />
<br />
== References ==<br />
<biblio><br />
#Helbert2019 pmid=30850540<br />
<br />
#Drula2022 pmid=34850161<br />
<br />
</biblio><br />
<br />
[[Category:Polysaccharide Lyase Families|PL032]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=Polysaccharide_Lyase_Family_30&diff=18341Polysaccharide Lyase Family 302024-08-23T15:27:16Z<p>Marie-Line Garron: </p>
<hr />
<div><!-- RESPONSIBLE CURATORS: Please replace the {{UnderConstruction}} tag below with {{CuratorApproved}} when the page is ready for wider public consumption --><br />
{{UnderConstruction}}<br />
* [[Author]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
* [[Responsible Curator]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
----<br />
<br />
<!-- The data in the table below should be updated by the Author/Curator according to current information on the family --><br />
<div style="float:right"><br />
{| {{Prettytable}} <br />
|-<br />
|{{Hl2}} colspan="2" align="center" |'''Polysaccharide Lyase Family PL30'''<br />
|-<br />
|'''3D Structure''' <br />
|<br />
|-<br />
|'''Mechanism''' <br />
|<br />
|-<br />
|'''Charge neutraliser'''<br />
|<br />
|-<br />
|'''Active site residues'''<br />
|<br />
|-<br />
|{{Hl2}} colspan="2" align="center" |'''CAZy DB link'''<br />
|-<br />
| colspan="2" |{{CAZyDBlink}}PL30.html<br />
|}<br />
</div><br />
<!-- This is the end of the table --><br />
<br />
<br />
== Substrate specificities ==<br />
PL30 is a small family (38 sequences), exclusively bacterial belonging to the phylum ''Bacteroidetes'' ([http://www.cazy.org/PL30.html PL30]) <cite>Drula2022</cite>. The founding member of family 30, and the only one characterized, belongs to ''Bacteroides cellulosilyticus WH2 (BcellWH2_02524, ''WP_029426181.1). The activity was measured against hyaluronic acid by following the absorbance at 232nm. The increase in absorbance confirms that ''BcellWH2_02524 ''is a hyaluronan lyase ([https://www.enzyme-database.org/query.php?ec=4.2.2.1 4.2.2.1]), probably using the by &beta;-elimination process like all PL families <cite>Helbert2019</cite>. <br />
<br />
== Kinetics and Mechanism ==<br />
Not Determined<br />
<br />
== Catalytic Residues ==<br />
Not Determined<br />
<br />
== Three-dimensional structures ==<br />
Unsolved<br />
<br />
== Family Firsts ==<br />
;First description of catalytic activity: Hyaluronan lyase was the first activity discovered for the family PL30 <cite>Helbert2019</cite>.<br />
;First charge neutralizer identification: To be determined<br />
;First Brønstead acid and base residue identification: To be determinated<br />
;First 3-D structure: To be determinated<br />
<br />
== References ==<br />
<biblio><br />
<br />
#Drula2022 pmid=34850161<br />
<br />
#Helbert2019 pmid=30850540<br />
</biblio><br />
<br />
[[Category:Polysaccharide Lyase Families|PL030]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=Polysaccharide_Lyase_Family_34&diff=18340Polysaccharide Lyase Family 342024-08-23T15:25:36Z<p>Marie-Line Garron: </p>
<hr />
<div><!-- RESPONSIBLE CURATORS: Please replace the {{UnderConstruction}} tag below with {{CuratorApproved}} when the page is ready for wider public consumption --><br />
{{UnderConstruction}}<br />
* [[Author]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
* [[Responsible Curator]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
----<br />
<br />
<!-- The data in the table below should be updated by the Author/Curator according to current information on the family --><br />
<div style="float:right"><br />
{| {{Prettytable}} <br />
|-<br />
|{{Hl2}} colspan="2" align="center" |'''Polysaccharide Lyase Family PL33'''<br />
|-<br />
|'''3D Structure''' <br />
|<br />
|-<br />
|'''Mechanism''' <br />
|<br />
|-<br />
|'''Charge neutraliser'''<br />
|<br />
|-<br />
|'''Active site residues'''<br />
|<br />
|-<br />
|{{Hl2}} colspan="2" align="center" |'''CAZy DB link'''<br />
|-<br />
| colspan="2" |{{CAZyDBlink}}PL33.html<br />
|}<br />
</div><br />
<!-- This is the end of the table --><br />
<br />
<br />
== Substrate specificities ==<br />
PL34 is a small family (28 sequences), mainly bacterial, with only one sequence belonging to the metazoan ''Knipowitschia caucasica'' ([http://www.cazy.org/PL34.html PL34])<cite>Drula2022</cite>. The founding member of family 34, and the only one characterized, belongs to OPIT5_18480 of Opitutaceae bacterium TAV5 (AHF91913.1). This enzyme presents an activity against alginate (EC 4.2.2.-) <cite>Helbert2019</cite>.<br />
<br />
== Kinetics and Mechanism ==<br />
Not determined<br />
<br />
== Catalytic Residues ==<br />
Not determined<br />
<br />
== Three-dimensional structures ==<br />
Unsolved<br />
<br />
== Family Firsts ==<br />
;First description of catalytic activity: Alginate lyase was the first activity discovered for the family PL34 <cite>Helbert2019</cite>. <br />
;First First charge neutralizer identification: To be determined<br />
;First Brønstead acid and base residue identification: To be determined<br />
;First 3-D structure: To be determined<br />
<br />
== References ==<br />
<biblio><br />
#Drula2022 pmid=34850161 <br />
#Helbert2019 pmid=30850540 <br />
</biblio><br />
<br />
[[Category:Polysaccharide Lyase Families|PL034]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=Polysaccharide_Lyase_Family_32&diff=18339Polysaccharide Lyase Family 322024-08-23T15:15:57Z<p>Marie-Line Garron: </p>
<hr />
<div><!-- RESPONSIBLE CURATORS: Please replace the {{UnderConstruction}} tag below with {{CuratorApproved}} when the page is ready for wider public consumption --><br />
{{UnderConstruction}}<br />
* [[Author]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
* [[Responsible Curator]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
----<br />
<br />
<br />
== Substrate specificities ==<br />
The PL32 family was created following the functional characterization of the ORF “HMPREF1071_02769” from ''Bacteroides salyersiae ''CL02T12C01 (EIY62149.1), which showed endo-mannuronan lyase activity ([https://www.enzyme-database.org/query.php?ec=4.2.2.3 EC 4.2.2.3]) <cite>Helbert2019</cite>. Shortly afterwards, the sequence was <u>'''reclassified'''</u> as PL_nc on the basis of structural modelling revealing that the catalytic domain was restricted to the N-terminal domain ([http://www.cazy.org/PL0.html PL_nc]) <cite>Drula2022</cite>. The small number of sequences and the proximity to the PL14 and PL36 families do not allow the creation of a new PL family. <br />
<br />
== References ==<br />
<biblio><br />
#Helbert2019 pmid=30850540<br />
<br />
#Drula2022 pmid=34850161<br />
<br />
</biblio><br />
<br />
[[Category:Polysaccharide Lyase Families|PL032]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=Polysaccharide_Lyase_Family_32&diff=18338Polysaccharide Lyase Family 322024-08-23T15:14:58Z<p>Marie-Line Garron: </p>
<hr />
<div><!-- RESPONSIBLE CURATORS: Please replace the {{UnderConstruction}} tag below with {{CuratorApproved}} when the page is ready for wider public consumption --><br />
{{UnderConstruction}}<br />
* [[Author]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
* [[Responsible Curator]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
----<br />
<br />
<br />
== Substrate specificities ==<br />
The PL32 family was created following the functional characterization of the ORF “HMPREF1071_02769” from ''Bacteroides salyersiae ''CL02T12C01 (EIY62149.1), which showed endo-mannuronan lyase activity ([https://www.enzyme-database.org/query.php?ec=4.2.2.3 EC 4.2.2.3]) <cite>Helbert2019</cite>. Shortly afterwards, the sequence was <u>'''reclassified'''</u> as PL_nc on the basis of structural modelling revealing that the catalytic domain was restricted to the N-terminal domain ([http://www.cazy.org/PL0.html PL_nc]) <cite>Drula2022</cite>. The small number of sequences and the proximity to the PL14 and PL36 families do not allow the creation of a new PL family. <br />
<br />
<br />
== References ==<br />
<biblio><br />
#Helbert2019 pmid=30850540<br />
<br />
#Drula2022 pmid=34850161<br />
<br />
</biblio><br />
<br />
[[Category:Polysaccharide Lyase Families|PL032]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=Polysaccharide_Lyase_Family_31&diff=18337Polysaccharide Lyase Family 312024-08-23T14:57:48Z<p>Marie-Line Garron: </p>
<hr />
<div><!-- RESPONSIBLE CURATORS: Please replace the {{UnderConstruction}} tag below with {{CuratorApproved}} when the page is ready for wider public consumption --><br />
{{UnderConstruction}}<br />
* [[Author]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
* [[Responsible Curator]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
----<br />
<br />
<!-- The data in the table below should be updated by the Author/Curator according to current information on the family --><br />
<div style="float:right"><br />
{| {{Prettytable}} <br />
|-<br />
|{{Hl2}} colspan="2" align="center" |'''Polysaccharide Lyase Family PL31'''<br />
|-<br />
|'''3D Structure''' <br />
|Right handed &beta;-helix<br />
|-<br />
|'''Mechanism''' <br />
|&beta;-elimination<br />
|-<br />
|'''Charge neutraliser'''<br />
|Divalent cation (based on docking)<br />
|-<br />
|'''Active site residues'''<br />
|Lysine (base) and Tyrosine (acid) (mutagenesis and docking)<br />
|-<br />
|{{Hl2}} colspan="2" align="center" |'''CAZy DB link'''<br />
|-<br />
| colspan="2" |{{CAZyDBlink}}PL31.html<br />
|}<br />
</div><br />
<!-- This is the end of the table --><br />
<br />
<br />
== Substrate specificities ==<br />
The PL31 family is mainly a bacterial family distantly related to the PL41 family ([http://www.cazy.org/PL31.html PL31]) <cite>Drula2022</cite>. The first activities were demonstrated against poly-glucuronan for ''Saccharophagus degradans 2-40'' (ABD82242.1) and ''Streptomyces hygroscopicus subsp. jinggangensis'' (AGF62897.1) ([https://www.enzyme-database.org/query.php?ec=4.2.2.14 EC 4.2.2.14]) <cite>Helbert2019</cite>. Shortly afterwards, another PL31 member with a different function was characterized. PsAly, from ''Paenibacillus sp. FPU-7'', is an endo-alginate lyase specific for polymannuronate ([https://www.enzyme-database.org/query.php?ec=4.2.2.3 EC 4.2.2.3]) <cite>Itoh2019</cite>. The poly-M specific alginate lyase function was confirmed by the characterization of paeh-aly, belonging to ''Paenibacillus ehimensis'' <cite>Wang2023</cite>. The two publications on poly-M alginate lyases also reported a significant increase in activity in the presence of divalent cations, mainly Mg<sup>2+</sup> <cite>Itoh2019 Wang2023</cite>. <br />
<br />
== Kinetics and Mechanism ==<br />
Like the other family of PLs, the PL31 family follows the same &beta;-elimination process, involving a neutralizer, a Brønstead base and an acid <cite>Garron2010</cite>. Based on the C5 and C4 orientation, there are two variations of the &beta;-elimination, the ''syn''-elimination, where the C4-oxygen of the glycosidic bond and the C5-abstracted proton are on the same side, and the inverse, the ''anti''-elimination <cite>Garron2010</cite>. Poly-glucuronan ([https://www.enzyme-database.org/query.php?ec=4.2.2.14 EC 4.2.2.14]) or poly-M specific alginate lyase ([https://www.enzyme-database.org/query.php?ec=4.2.2.3 EC 4.2.2.3]) require a ''syn''-elimination mechanism, in which case the Brønstead base and acid roles can be played, sometimes by the same amino acid. <br />
Several mutants of PsAly have been realized by Itoh and co-workers. Activity is completely lost for the Y184F and K221A mutants and greatly reduced when several charged amino acids in the catalytic pocket are mutated. To discriminate the exact role of Y184 and K221, and in the absence of structures with products or substrate, docking simulations were performed. Based on the docking, the authors hypothesis that K221 could be the Brønstead base and Y184 the Brønstead acid, while the carboxylate would be neutralized by a divalent cation <cite>Itoh2019</cite>.<br />
<br />
<br />
== Three-dimensional structures ==<br />
PL31 presents a right handed &beta;-helix fold, which is already found in several PL families such as PL1, 3 or the alginate family PL6 <cite>Huang1999</cite>. The only structure available has been solved at high resolution (0,89Å) ([https://www.rcsb.org/structure/6KFN PDB 6KFN]) and is composed of 10 &beta;-stand coils and one &alpha;-helix capping the N-terminus extremity <cite>Itoh2019</cite>. Despite the difference in function, the closest structural homologue is Pel9A, a pectate lyase of the PL9 family ([https://www.rcsb.org/structure/1RU4 PDB 1RU4])<cite>Itoh2019 Jenkins2004</cite>. The structure of PSAly was solved with 2 sodium ions in the catalityc cleft, identified by the authors on the basis of the structural homology. <br />
<br />
== Family Firsts ==<br />
;First desciption of catalytic activity: Glucuronan lyase was the first activity reported for the family PL31 <cite>Helbert2019</cite>.<br />
<br />
;First charge neutralizer identification: Based on the influence of cations on activity and the docking experiments, Itoh and co-workers hypothesised that divalent cations could be the neutralizer <cite>Itoh2019</cite>. <br />
<br />
;First Brønstead acid and base residue identification: The total loss of activity when PsAly is mutated on Y184 and K221, confirms their crucial role in catalysis. The base and acid functions were assigned on the basis of docking: Lys the base and Tyr the acid <cite>Itoh2019</cite>. <br />
<br />
;First 3-D structure: The structure of the poly-M specific alginate lyase, PSAly, was the first solved by X-ray diffraction at 0.89Å resolution ([https://www.rcsb.org/structure/6KFN PDB 6KFN]) <cite>Itoh2019</cite>.<br />
<br />
== References ==<br />
<biblio><br />
#Drula2022 pmid=18838391<br />
#Helbert2019 pmid=30850540<br />
#Itoh2019 pmid=31619701<br />
#Wang2023 pmid=36906979<br />
#Garron2010 pmid=20805221<br />
<br />
#Huang1999 pmid=10600383<br />
#Jenkins2004 pmid=14670977<br />
<br />
</biblio><br />
<br />
[[Category:Polysaccharide Lyase Families|PL031]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=Polysaccharide_Lyase_Family_30&diff=18336Polysaccharide Lyase Family 302024-08-23T13:24:53Z<p>Marie-Line Garron: </p>
<hr />
<div><!-- RESPONSIBLE CURATORS: Please replace the {{UnderConstruction}} tag below with {{CuratorApproved}} when the page is ready for wider public consumption --><br />
{{UnderConstruction}}<br />
* [[Author]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
* [[Responsible Curator]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
----<br />
<br />
<!-- The data in the table below should be updated by the Author/Curator according to current information on the family --><br />
<div style="float:right"><br />
{| {{Prettytable}} <br />
|-<br />
|{{Hl2}} colspan="2" align="center" |'''Polysaccharide Lyase Family PL30'''<br />
|-<br />
|'''3D Structure''' <br />
|<br />
|-<br />
|'''Mechanism''' <br />
|<br />
|-<br />
|'''Charge neutraliser'''<br />
|<br />
|-<br />
|'''Active site residues'''<br />
|<br />
|-<br />
|{{Hl2}} colspan="2" align="center" |'''CAZy DB link'''<br />
|-<br />
| colspan="2" |{{CAZyDBlink}}PL30.html<br />
|}<br />
</div><br />
<!-- This is the end of the table --><br />
<br />
<br />
== Substrate specificities ==<br />
PL30 is a small family (38 sequences), exclusively bacterial belonging to the phylum ''Bacteroidetes'' ([http://www.cazy.org/PL30.html PL30]) <cite>Drula2022</cite>. The founding member of family 30, and the only one characterized, belongs to ''Bacteroides cellulosilyticus WH2 (BcellWH2_02524, ''WP_029426181.1). The activity was measured against hyaluronic acid by following the absorbance at 232nm. The increase in absorbance confirms that ''BcellWH2_02524 ''is a hyaluronan lyase ([https://www.enzyme-database.org/query.php?ec=4.2.2.1 4.2.2.1]), probably using the by &beta;-elimination process like all PL families <cite>Helbert2019</cite>. <br />
<br />
== Kinetics and Mechanism ==<br />
Not Determined<br />
<br />
== Catalytic Residues ==<br />
Not Determined<br />
<br />
== Three-dimensional structures ==<br />
Unsolved<br />
<br />
== Family Firsts ==<br />
;First description of catalytic activity: Hyaluronan lyase was the first activity discovered for the family PL30 <cite>Helbert2019</cite>.<br />
;First catalytic base identification: Content is to be added here.<br />
;First catalytic acid identification: Content is to be added here.<br />
;First 3-D structure: Content is to be added here.<br />
<br />
== References ==<br />
<biblio><br />
<br />
#Drula2022 pmid=34850161<br />
<br />
#Helbert2019 pmid=30850540<br />
</biblio><br />
<br />
[[Category:Polysaccharide Lyase Families|PL030]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=Polysaccharide_Lyase_Family_30&diff=18335Polysaccharide Lyase Family 302024-08-23T13:21:52Z<p>Marie-Line Garron: </p>
<hr />
<div><!-- RESPONSIBLE CURATORS: Please replace the {{UnderConstruction}} tag below with {{CuratorApproved}} when the page is ready for wider public consumption --><br />
{{UnderConstruction}}<br />
* [[Author]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
* [[Responsible Curator]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
----<br />
<br />
<!-- The data in the table below should be updated by the Author/Curator according to current information on the family --><br />
<div style="float:right"><br />
{| {{Prettytable}} <br />
|-<br />
|{{Hl2}} colspan="2" align="center" |'''Polysaccharide Lyase Family PL30'''<br />
|-<br />
|'''3D Structure''' <br />
|<br />
|-<br />
|'''Mechanism''' <br />
|<br />
|-<br />
|'''Charge neutraliser'''<br />
|<br />
|-<br />
|'''Active site residues'''<br />
|<br />
|-<br />
|{{Hl2}} colspan="2" align="center" |'''CAZy DB link'''<br />
|-<br />
| colspan="2" |{{CAZyDBlink}}PL30.html<br />
|}<br />
</div><br />
<!-- This is the end of the table --><br />
<br />
<br />
== Substrate specificities ==<br />
PL30 is a small family (38 sequences), exclusively bacterial belonging to the phylum ''Bacteroidetes'' ([http://www.cazy.org/PL30.html PL30]) <cite>Drula2022</cite>. The founding member of family 30, and the only one characterized, belongs to ''Bacteroides cellulosilyticus WH2 (BcellWH2_02524, ''WP_029426181.1). The activity was measured against hyaluronic acid by following the absorbance at 232nm. The increase in absorbance confirms that ''BcellWH2_02524 ''is a hyaluronan lyase ([https://www.enzyme-database.org/query.php?ec=4.2.2.1 4.2.2.1]), probably using the by b-elimination process like all PL families <cite>Helbert2019</cite>. <br />
<br />
== Kinetics and Mechanism ==<br />
Not Determined<br />
<br />
== Catalytic Residues ==<br />
Not Determined<br />
<br />
== Three-dimensional structures ==<br />
Unsolved<br />
<br />
== Family Firsts ==<br />
;First description of catalytic activity: Hyaluronan lyase was the first activity discovered for the family PL30 <cite>Helbert2019</cite>.<br />
;First catalytic base identification: Content is to be added here.<br />
;First catalytic acid identification: Content is to be added here.<br />
;First 3-D structure: Content is to be added here.<br />
<br />
== References ==<br />
<biblio><br />
<br />
#Drula2022 pmid=34850161<br />
<br />
#Helbert2019 pmid=30850540<br />
</biblio><br />
<br />
[[Category:Polysaccharide Lyase Families|PL030]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=Polysaccharide_Lyase_Family_30&diff=18334Polysaccharide Lyase Family 302024-08-23T13:16:03Z<p>Marie-Line Garron: </p>
<hr />
<div><!-- RESPONSIBLE CURATORS: Please replace the {{UnderConstruction}} tag below with {{CuratorApproved}} when the page is ready for wider public consumption --><br />
{{UnderConstruction}}<br />
* [[Author]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
* [[Responsible Curator]]: [[User:Marie-Line Garron|Marie-Line Garron]]<br />
----<br />
<br />
<!-- The data in the table below should be updated by the Author/Curator according to current information on the family --><br />
<div style="float:right"><br />
{| {{Prettytable}} <br />
|-<br />
|{{Hl2}} colspan="2" align="center" |'''Polysaccharide Lyase Family PL30'''<br />
|-<br />
|'''3D Structure''' <br />
|<br />
|-<br />
|'''Mechanism''' <br />
|<br />
|-<br />
|'''Charge neutraliser'''<br />
|<br />
|-<br />
|'''Active site residues'''<br />
|<br />
|-<br />
|{{Hl2}} colspan="2" align="center" |'''CAZy DB link'''<br />
|-<br />
| colspan="2" |{{CAZyDBlink}}PL30.html<br />
|}<br />
</div><br />
<!-- This is the end of the table --><br />
<br />
<br />
== Substrate specificities ==<br />
PL30 is a small family (38 sequences), exclusively bacterial belonging to the phylum ''Bacteroidetes'' ([http://www.cazy.org/PL30.html PL30]) <cite>Drula2022</cite>. The founding member of family 30, and the only one characterized, belongs to ''Bacteroides cellulosilyticus WH2 (BcellWH2_02524, ''WP_029426181.1). The activity was measured against hyaluronic acid by following the absorbance at 232nm. The increase in absorbance confirms that ''BcellWH2_02524 ''is a hyaluronan lyase ([https://www.enzyme-database.org/query.php?ec=4.2.2.1 4.2.2.1]), probably using the by b-elimination process like all PL families <cite>Helbert2019</cite>. <br />
<br />
== Kinetics and Mechanism ==<br />
Not Determined<br />
<br />
== Catalytic Residues ==<br />
Not Determined<br />
<br />
== Three-dimensional structures ==<br />
Unsolved<br />
<br />
== Family Firsts ==<br />
;First stereochemistry determination: Content is to be added here.<br />
;First catalytic nucleophile identification: Content is to be added here.<br />
;First general acid/base residue identification: Content is to be added here.<br />
;First 3-D structure: Content is to be added here.<br />
<br />
== References ==<br />
<biblio><br />
<br />
#Drula2022 pmid=34850161<br />
<br />
#Helbert2019 pmid=30850540<br />
</biblio><br />
<br />
[[Category:Polysaccharide Lyase Families|PL030]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15368User:Marie-Line Garron2020-06-16T15:34:32Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:MLG.png|200px|right]]<br />
After a Ph.D. obtained in 2007 from the University of Montpellier (France), I joined Mirek Cygler's group, as postdoctoral student, at the Biotechnological Reasearch Institut (Montreal, QC, Canada). My postdoctoral research focused on the structure and function of CAZymes involved in synthesis and degradation of glycosaminoglycans (GAGs), and in particular on Polysaccharide Lyases on which I wrote two reviews.<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral researcher in charge of strengthening the functional and structural side of the team. I then obtained a permanent position as Assistant Professor in [https://www.univ-amu.fr/ Aix-Marseille University] in 2011.<br />
<br />
I currently manage the updates of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal research interests are with the biochemical and structural characterization of distant members of CAZy families and with the discovery of new CAZymes families.<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
#Garron2014 pmid=25156747<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
#Henrissat2017 pmid=28877502<br />
#Ulaganathan2017 pmid=27621378<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
#Zhao2011 pmid=21741976<br />
<br />
#Han2009 pmid=19801541<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15367User:Marie-Line Garron2020-06-16T15:34:07Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:MLG.png|200px|right]]<br />
After a Ph.D. obtained in 2007 from the University of Montpellier (France), I joined Mirek Cygler's group, as postdoctoral student, at the Biotechnological Reasearch Institut (Montreal, QC, Canada). My postdoctoral research focused on the structure and function of CAZymes involved in synthesis and degradation of glycosaminoglycans (GAGs), and in particular on Polysaccharide Lyases on which I wrote two reviews.<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral researcher in charge of strengthening the functional and structural side of the team. I then obtained a permanent position as Assistant Professor in [https://www.univ-amu.fr/ Aix-Marseille University] in 2011.<br />
<br />
I currently manage the updates of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal research interests are with the biochemical and structural characterization of distant members of CAZy families and with the discovery of new CAZymes families.<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
#Garron2014 pmid=25156747<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
#Henrissat2017 pmid=28877502<br />
#Ulaganathan2017 pmid=27621378<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
#Zhao2011 pmid=21741976<br />
<br />
#Han2009 pmid=19801541<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15366User:Marie-Line Garron2020-06-16T15:33:23Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:MLG.png|200px|right]]<br />
After a Ph.D. obtained in 2007 from the University of Montpellier (France), I joined Mirek Cygler's group, as postdoctoral student, at the Biotechnological Reasearch Institut (Montreal, QC, Canada). My postdoctoral research focused on the structure and function of CAZymes involved in synthesis and degradation of glycosaminoglycans (GAGs), and in particular on Polysaccharide Lyases on which I wrote two reviews.<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral researcher in charge of strengthening the functional and structural side of the team. I then obtained a permanent position as Assistant Professor in [https://www.univ-amu.fr/ Aix-Marseille University] in 2011.<br />
<br />
I currently manage the updates of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal research interests are with the discovery of new CAZymes families.<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
#Garron2014 pmid=25156747<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
#Henrissat2017 pmid=28877502<br />
#Ulaganathan2017 pmid=27621378<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
#Zhao2011 pmid=21741976<br />
<br />
#Han2009 pmid=19801541<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15365User:Marie-Line Garron2020-06-16T15:32:06Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:MLG.png|200px|right]]<br />
After a Ph.D. obtained in 2007 from the University of Montpellier (France), I joined Mirek Cygler's group, as postdoctoral student, at the Biotechnological Reasearch Institut (Montreal, QC, Canada). My postdoctoral research focused on the structure and function of CAZymes involved in synthesis and degradation of glycosaminoglycans (GAGs), and in particular on Polysaccharide Lyases on which I wrote two reviews.<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral researcher in charge of strengthening the functional and structural side of the team. I then obtained a permanent position as Assistant Professor in [https://www.univ-amu.fr/ Aix-Marseille University] in 2011. I currently manage the updates of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal research interests are with the discovery of new CAZymes families.<br />
<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
#Garron2014 pmid=25156747<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
#Henrissat2017 pmid=28877502<br />
#Ulaganathan2017 pmid=27621378<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
#Zhao2011 pmid=21741976<br />
<br />
#Han2009 pmid=19801541<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15364User:Marie-Line Garron2020-06-16T15:30:43Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:MLG.png|200px|right]]<br />
After a Ph.D. obtained in 2007 from the University of Montpellier (France), I joined Mirek Cygler's group, as postdoctoral researcher for 3 years , at the Biotechnological Reasearch Institut (Montreal, QC, Canada) with whom I started working on CAZymes. My research focused on the structure and function of CAZymes involved in synthesis and degradation of glycosaminoglycans (GAGs), and in particular on Polysaccharide Lyases on which I wrote two reviews.<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral researcher in charge of strengthening the functional and structural side of the team. I then obtained a permanent position as Assistant Professor in [https://www.univ-amu.fr/ Aix-Marseille University] in 2011. I currently manage the updates of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal research interests are with the discovery of new CAZymes families.<br />
<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
#Garron2014 pmid=25156747<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
#Henrissat2017 pmid=28877502<br />
#Ulaganathan2017 pmid=27621378<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
#Zhao2011 pmid=21741976<br />
<br />
#Han2009 pmid=19801541<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15363User:Marie-Line Garron2020-06-16T15:28:49Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:MLG.png|200px|right]]<br />
After a Ph.D. obtained in 2007 from the University of Montpellier (France), I joined Mirek Cygler's group for 3 years as postdoctoral student, at the Biotechnological Reasearch Institut (Montreal, QC, Canada) with whom I started working on CAZymes. My research focused on the structure and function of CAZymes involved in synthesis and degradation of glycosaminoglycans (GAGs), and in particular on Polysaccharide Lyases on which I wrote two reviews.<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral researcher in charge of strengthening the functional and structural side of the team. I then obtained a permanent position as Assistant Professor in [https://www.univ-amu.fr/ Aix-Marseille University] in 2011. I currently manage the updates of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal research interests are with the discovery of new CAZymes families.<br />
<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
#Garron2014 pmid=25156747<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
#Henrissat2017 pmid=28877502<br />
#Ulaganathan2017 pmid=27621378<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
#Zhao2011 pmid=21741976<br />
<br />
#Han2009 pmid=19801541<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15362User:Marie-Line Garron2020-06-16T15:28:10Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:MLG.png|200px|right]]<br />
After a Ph.D. obtained in 2007 from University of Montpellier (France), I joined Mirek Cygler's group for 3 years as postdoctoral student, at the Biotechnological Reasearch Institut (Montreal, QC, Canada) with whom I started working on CAZymes. My research focused on the structure and function of CAZymes involved in synthesis and degradation of glycosaminoglycans (GAGs), and in particular on Polysaccharide Lyases on which I wrote two reviews.<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral researcher in charge of strengthening the functional and structural side of the team. I then obtained a permanent position as Assistant Professor in [https://www.univ-amu.fr/ Aix-Marseille University] in 2011. I currently manage the updates of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal research interests are with the discovery of new CAZymes families.<br />
<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
#Garron2014 pmid=25156747<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
#Henrissat2017 pmid=28877502<br />
#Ulaganathan2017 pmid=27621378<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
#Zhao2011 pmid=21741976<br />
<br />
#Han2009 pmid=19801541<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15361User:Marie-Line Garron2020-06-16T15:27:51Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:MLG.png|200px|right]]<br />
After a Ph.D. obtained in 2007 from University of Montpellier (France), I joined Mirek Cygler's group for 3 years as postdoctoral student, at the Biotechnological Reasearch Institut (Montreal, QC, Canada) with whom I started working on CAZymes. My research focused on the structure and function of CAZymes involved in synthesis and degradation of glycosaminoglycans (GAGs), and in particular on Polysaccharide Lyases on which I wrote two reviews.<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral researcher in charge of strengthening the functional and structural side of the team. I then obtained a permanent position as Assistant Professor in [https://www.univ-amu.fr/ Aix-Marseille University] in 2011. I currently manage the updates of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal research interests are with the discovery of new CAZymes families.<br />
<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
#Garron2014 pmid=25156747<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
#Henrissat2017 pmid=28877502<br />
#Ulaganathan2017 pmid=27621378<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
#Zhao2011 pmid=21741976<br />
<br />
#Han2009 pmid=19801541<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=File:MLG.png&diff=15360File:MLG.png2020-06-16T11:50:32Z<p>Marie-Line Garron: </p>
<hr />
<div></div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15359User:Marie-Line Garron2020-06-16T11:49:05Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:MLG.png|200px|right]]<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases on which I wrote two reviews.<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
#Garron2014 pmid=25156747<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
#Henrissat2017 pmid=28877502<br />
#Ulaganathan2017 pmid=27621378<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
#Zhao2011 pmid=21741976<br />
<br />
#Han2009 pmid=19801541<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15352User:Marie-Line Garron2020-06-15T21:17:04Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:Image.png|200px|right]]<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases on which I wrote two reviews.<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
#Garron2014 pmid=25156747<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
#Henrissat2017 pmid=28877502<br />
#Ulaganathan2017 pmid=27621378<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
#Zhao2011 pmid=21741976<br />
<br />
#Han2009 pmid=19801541<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15351User:Marie-Line Garron2020-06-15T21:16:31Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image::p.png|200px|right]]<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases on which I wrote two reviews.<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
#Garron2014 pmid=25156747<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
#Henrissat2017 pmid=28877502<br />
#Ulaganathan2017 pmid=27621378<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
#Zhao2011 pmid=21741976<br />
<br />
#Han2009 pmid=19801541<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15350User:Marie-Line Garron2020-06-15T21:15:52Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:-200px.png|200px|right]]<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases on which I wrote two reviews.<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
#Garron2014 pmid=25156747<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
#Henrissat2017 pmid=28877502<br />
#Ulaganathan2017 pmid=27621378<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
#Zhao2011 pmid=21741976<br />
<br />
#Han2009 pmid=19801541<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15349User:Marie-Line Garron2020-06-15T21:10:04Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:MLG-200px.png|200px|right]]<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases on which I wrote two reviews.<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
#Garron2014 pmid=25156747<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
#Henrissat2017 pmid=28877502<br />
#Ulaganathan2017 pmid=27621378<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
#Zhao2011 pmid=21741976<br />
<br />
#Han2009 pmid=19801541<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15348User:Marie-Line Garron2020-06-15T21:04:39Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:Blank_user-200px.png|200px|right]]<br />
<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases on which I wrote two reviews.<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
#Garron2014 pmid=25156747<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
#Henrissat2017 pmid=28877502<br />
#Ulaganathan2017 pmid=27621378<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
#Zhao2011 pmid=21741976<br />
<br />
#Han2009 pmid=19801541<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15347User:Marie-Line Garron2020-06-15T21:01:10Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:Blank_user-200px.png|200px|right]]<br />
<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases and I solved the first structure of PL13 family.<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
#Garron2014 pmid=25156747<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
#Henrissat2017 pmid=28877502<br />
#Ulaganathan2017 pmid=27621378<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
#Zhao2011 pmid=21741976<br />
<br />
#Han2009 pmid=19801541<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15346User:Marie-Line Garron2020-06-15T21:00:14Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:Blank_user-200px.png|200px|right]]<br />
<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases and I solved the first structure of PL13 family <cite>Han2009</cite>.<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
#Garron2014 pmid=25156747<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
#Henrissat2017 pmid=28877502<br />
#Ulaganathan2017 pmid=27621378<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
#Zhao2011 pmid=21741976<br />
<br />
#Han2009 pmid=1980154<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15345User:Marie-Line Garron2020-06-15T20:59:17Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:Blank_user-200px.png|200px|right]]<br />
<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases and I solved the first structure of PL13 family <cite>Han2009</cite>.<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
<br />
#Garron2014 pmid=25156747<br />
<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
<br />
#Henrissat2017 pmid=28877502<br />
<br />
#Ulaganathan2017 pmid=27621378<br />
<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
<br />
#Zhao2011 pmid=21741976<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15344User:Marie-Line Garron2020-06-15T20:58:02Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:Blank_user-200px.png|200px|right]]<br />
<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases and I solved the first structure of PL13 family <cite>Han2009</cite>.<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
<br />
#Garron2014 pmid=25156747<br />
<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
<br />
#Henrissat2017 pmid=28877502<br />
<br />
#Ulaganathan2017 pmid=27621378<br />
<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
<br />
#Zhao2011 pmid=21741976<br />
<br />
#Han2009 pmid=19801541<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15343User:Marie-Line Garron2020-06-15T20:55:22Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:Blank_user-200px.png|200px|right]]<br />
<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases and I solved the first structure of [[PL13]] family (Ref).<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
<br />
#Garron2014 pmid=25156747<br />
<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
<br />
#Henrissat2017 pmid=28877502<br />
<br />
#Ulaganathan2017 pmid=27621378<br />
<br />
#Lafond2016 pmid=26755730<br />
#Shaya2010 pmid=20404324<br />
<br />
#Zhao2011 pmid=21741976<br />
<br />
#Han2009 pmid=19801541<br />
<br />
#Xiao2008 pmid=18156340<br />
</biblio><br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15342User:Marie-Line Garron2020-06-15T20:52:19Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:Blank_user-200px.png|200px|right]]<br />
<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases and I solved the first structure of [[PL13]] family (Ref).<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
==== Reviews ====<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
<br />
#Garron2014 pmid=25156747<br />
<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
==== Publications ====<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
<br />
#Henrissat2017 pmid=28877502<br />
<br />
#Ulaganathan2017 pmid=27621378<br />
</biblio><br />
<br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15339User:Marie-Line Garron2020-06-15T20:44:10Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:Blank_user-200px.png|200px|right]]<br />
<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases and I solved the first structure of PL13 family (Ref).<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
Reviews<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
<br />
#Garron2014 pmid=25156747<br />
<br />
#Garron2010 pmid=20805221<br />
----<br />
Pubications<br />
<br />
#Turbe-Doan2019 pmid=31604773<br />
</biblio><br />
<br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15338User:Marie-Line Garron2020-06-15T20:42:16Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:Blank_user-200px.png|200px|right]]<br />
<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases and I solved the first structure of PL13 family (Ref).<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
Reviews<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
<br />
#Garron2014 pmid=25156747<br />
<br />
#Garron2010 pmid=20805221<br />
<br />
</biblio><br />
<br />
----<br />
Pubications<br />
<br />
<biblio><br />
#Turbe-Doan2019 pmid=31604773<br />
</biblio><br />
<br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15337User:Marie-Line Garron2020-06-15T20:39:27Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:Blank_user-200px.png|200px|right]]<br />
<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases and I solved the first structure of PL13 family (Ref).<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the [http://www.cazy.org/ CAZy database]. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
Reviews<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
<br />
#Garron2014 pmid=25156747<br />
<br />
#Garron2010 pmid=20805221<br />
</biblio><br />
<br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15336User:Marie-Line Garron2020-06-15T20:38:44Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:Blank_user-200px.png|200px|right]]<br />
<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases and I solved the first structure of PL13 family (Ref).<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the [http://cazy.org/ CAZy database]. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
Reviews<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
<br />
#Garron2014 pmid=25156747<br />
<br />
#Garron2010 pmid=20805221<br />
</biblio><br />
<br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15335User:Marie-Line Garron2020-06-15T20:32:33Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:Blank_user-200px.png|200px|right]]<br />
<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases and I solved the first structure of PL13 family (Ref).<br />
<br />
In 2010, I joined the glycogenomic group, led by ^^^Bernard Henrissat^^^ at [http://www.afmb.univ-mrs.fr/ AFMB] laboratory (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the CAZy database. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
Reviews<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
<br />
#Garron2014 pmid=25156747<br />
<br />
#Garron2010 pmid=20805221<br />
</biblio><br />
<br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15334User:Marie-Line Garron2020-06-15T20:27:12Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:Blank_user-200px.png|200px|right]]<br />
<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases and I solved the first structure of PL13 family (Ref).<br />
<br />
In 2010, I joined the glycogenomic group, led by Bernard Henrissat at AFMB (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the CAZy database. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
Reviews<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
<br />
#Garron2014 pmid=25156747<br />
<br />
#Garron2010 pmid=20805221<br />
</biblio><br />
<br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15333User:Marie-Line Garron2020-06-15T20:25:14Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:Blank_user-200px.png|200px|right]]<br />
<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases and I solved the first structure of PL13 family (Ref).<br />
<br />
In 2010, I joined the glycogenomic group, led by Bernard Henrissat at AFMB (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the CAZy database. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
Reviews<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
<br />
</biblio><br />
<br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15332User:Marie-Line Garron2020-06-15T20:19:52Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:Blank_user-200px.png|200px|right]]<br />
<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases and I solved the first structure of PL13 family (Ref).<br />
<br />
In 2010, I joined the glycogenomic group, led by Bernard Henrissat at AFMB (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the CAZy database. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
<br />
</biblio><br />
<br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15331User:Marie-Line Garron2020-06-15T20:18:50Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:Blank_user-200px.png|200px|right]]<br />
<br />
I started working on CAZymes in 2007 when I joined the group of Mirek Cygler, as postdoctoral student, in the Biotechnological Reasearch Institut (BRI) at Montreal, QC, Canada. I spent three years on functional et structural studies of different CAZymes involved in synthesis and degradation of Glycosaminoglycans (GAGs). During this period, I mainly worked on Polysaccharide Lyases and I solved the first structure of PL13 family (Ref).<br />
In 2010, I joined the glycogenomic group, led by Bernard Henrissat at AFMB (Marseille, France), as postdoctoral student to strengthen the functional and structural side of the team. I obtained my permanent position as assistant professor in Aix-Marseille University in 2011. Currently, I manage the updating of structural and functional information in the CAZy database. My personal researches interest are oriented to the characterization of poorly characterized CAZymes families or the discovery of new CAZymes families.<br />
<br />
----<br />
<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
<br />
</biblio><br />
<br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garronhttps://www.cazypedia.org/index.php?title=User:Marie-Line_Garron&diff=15330User:Marie-Line Garron2020-06-15T20:10:55Z<p>Marie-Line Garron: </p>
<hr />
<div>[[Image:Blank_user-200px.png|200px|right]]<br />
'''This is an empty template to help you get started with composing your User page.'''<br />
<br />
You should begin by opening this page for editing by clicking on the Edit tab above. Your biography goes in this area of the page.<br />
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* See [[User:Gerlind_Sulzenbacher]] for an example. You may copy text from this example by opening the page in another browser window and clicking the "Edit" tab.<br />
* Add your publications in the list below using PubMed IDs and cite them in the text like this <cite>Gilbert2008</cite>.<br />
* Please upload a picture of yourself using the "Upload file" link in the Toolbox section of the left menu, and then replace the Image filename with your own.<br />
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<br />
<br />
<br />
----<br />
<br />
<biblio><br />
#Garron2019 pmid=31550558<br />
<br />
</biblio><br />
<br />
<!-- Do not remove this Category tag --><br />
[[Category:Contributors|Garron,Marie-Line]]</div>Marie-Line Garron