Template:OlderNews - Revision history

Harry Brumer at 18:50, 3 November 2025

2025-11-03T18:50:09Z

Harry Brumer at 18:49, 3 November 2025

2025-11-03T18:49:45Z

Harry Brumer at 18:49, 3 November 2025

2025-11-03T18:49:17Z

Harry Brumer at 16:55, 22 July 2024

2024-07-22T16:55:27Z

Harry Brumer at 15:08, 2 May 2024

2024-05-02T15:08:12Z

Harry Brumer at 15:07, 2 May 2024

2024-05-02T15:07:54Z

Harry Brumer at 17:59, 30 January 2024

2024-01-30T17:59:05Z

Harry Brumer at 14:24, 28 August 2023

2023-08-28T14:24:31Z

Harry Brumer at 14:23, 28 August 2023

2023-08-28T14:23:57Z

Harry Brumer: standardized punctuation

2023-06-15T16:24:40Z

standardized punctuation

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 '''1 November 2024:''' ''Is this a world record? Six CAZypedia families in one fell swoop!'' The '''[[CBM47]], [[CBM70]], [[CBM96]], [[CBM105]], [[CBM106]] and [[PL44]]''' ''CAZypedia'' pages are now flipped to [[Curator Approved]] status. What do these diverse families from diverse origins with diverse binding specificities have in common?  Astonishingly, at least one characterized member from each family interacts with a charged glycan! '''[[User:Wenwen Tao|Wenwen Tao]]''' authored the [[CBM47]], [[CBM96]] and [[CBM106]] pages, '''[[User:Menghui Sun|Menghui Sun]]''' authored the [[CBM70]] page, '''[[User:Guanchen Liu|Guanchen Liu]]''' authored the [[CBM105]] page and '''[[User:Jinhang Zhou|Jinhang Zhou]]''' authored the [[PL44]] page.  All this under the responsible curatorship of '''[[User:Yaoguang Chang|Yaoguang Chang]]'''. ''Dive into these diverse families on their respective ''CAZypedia'' pages: '''[[CBM47]], [[CBM70]], [[CBM96]], [[CBM105]], [[CBM106]] and [[PL44]]!'''''
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+----
 '''25 October 2024:''' ''Laminariawesome!'' Check out two new marine families of CBMs, '''[[CBM102]]''' and '''[[CBM103]]''', now on ''CAZypedia'' which have an ecological role in bacterial degradation of laminarin during phytoplankton blooms.  Some function as surface glycan binding proteins but others have roles in targeting their appended catalytic modules to substrate.  Both pages were [[author]]ed by '''[[User:Marie-Katherin Zuehlke|Marie-Katherin Zühlke]]'''. ''Read up on these environmentally important CBMs on their respective [[CBM102]] and [[CBM103]] pages!''
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@@ Line 9: / Line 9: @@
 '''2 May 2024:''' ''CBDs I to X... A major milestone!'' '''CBM families 1 to 10 are now complete!''' These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old-school families on their respective ''CAZypedia'' pages: '''[[CBM1]], [[CBM2]], [[CBM3]], [[CBM4]], [[CBM5]], [[CBM6]], [[CBM7]], [[CBM8]], [[CBM9]], and [[CBM10]]'''.
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 '''11 February 2024:''' ''A "BLAST" from the past, with a fresh update.'' [[Author]] '''[[User:Eduardo Moreno Prieto|Eduardo Moreno Prieto]]''' composed a new page on '''[[Glycoside Hydrolase Family 119]]''',a family of bacterial amylases, which was [[Curator Approved]] by '''[[User:Stefan Janecek|Stefan Janecek]]''' and '''[[User:Bernard Henrissat|Bernard Henrissat]]''' today.  The first member of '''[[GH119]]''' was characterized in 2006, and through sequence analysis with [[GH57]] members, [[User:Stefan Janecek|Janeček]] and Kuchtová predicted the active-site residues in 2012.  Over a decade later, '''[[User:Eduardo Moreno Prieto|Eduardo]]''', '''[[User:Bernard Henrissat|Bernard]]''', and colleagues finally provided critical experimental support for these predictions.  ''Learn more about this history, and especially the relationship between '''[[GH119]]''' and '''[[GH57]]''', in CAZypedia.''
 ----
 '''3 February 2024:''' ''A new family of beta-1,2-glucan-cyclizing enzymes.'' A page on the (currently) newest GH family, '''[[Glycoside Hydrolase Family 189]]''', was completed today by [[Author]]s '''[[User:Tomoko Masaike|Tomoko Masaike]]''', '''[[User:Masahiro Nakajima|Masahiro Nakajima]]''', and '''[[User:Nobukiyo Tanaka|Nobukiyo Tanaka]]''' ([[User:Masahiro Nakajima|Masahiro Nakajima]] is the [[Responsible Curator]]). '''[[GH189]]''' is a family of bacterial transglycosylases that comprise a critical domain in cyclic beta-1,2-glucan synthase (CGS), because this domain is responsible for the final cyclization step during the biosynthesis of these key effector molecules.  The discovery of '''[[GH189]]''' builds on similarly exciting work by these authors and their colleagues on beta-1,2-glucan hydrolases in [[GH144]] and [[GH162]], which share a common protein fold with '''[[GH189]]''', but have distinct mechansims. ''Check out the '''[[GH189]]''', [[GH144]], and [[GH162]] pages to learn more about this breakthrough work on beta-1,2-glucan-active enzymes!''
 ----
 '''4 January 2024:''' ''CBM99, CBM100 and CBM101 in one fell swoop!'' Three new CBM families have been added to the ''CAZypedia'' repertoire. Though the families differ in their glycan targets, they share the interesting function of binding to highly complex sulfated marine polymers. '''[[User:Yaoguang Chang|Yaoguang Chang]]''' acted as [[Responsible Curator]] on all three pages. '''[[User:Xuanwei Mei|Xuanwei Mei]]''' [[author]]ed the [[CBM99]] and [[CBM101]] red algal specific pages and '''[[User:Guanchen Liu|Guanchen Liu]]''' authored the [[CBM100]] glycosaminoglycan specific page. ''Learn more about [[CBM99]], [[CBM100]] and [[CBM101]] on their respective pages!''
 ----
 '''4 January 2024:''' ''More "Fun" from the sea.'' Today, '''[[User:Yaoguang Chang|Yaoguang Chang]]''' [[Curator Approved]] the '''[[Glycoside Hydrolase Family 187]]''' page [[Author]]ed by '''[[User:Jingjing Shen|Jingjing Shen]]'''. The founding member of '''[[GH187]]''' is the alpha-1,3-L-fucanase ("Fun187A") the marine bacterium ''Wenyingzhuangia aestuarii'', which recognizes a specific sulfated motif in sea cucumber fucans.  '''[[GH187]]''' is a small family (<50 members) and there remains much to elucidate regarding catalytic mechanism and enzyme structure. Interest in CAZymes active on marine biomass continues to grow, and we welcome this expansion in ''CAZypedia''. ''Learn more about '''[[GH187|GH187 here!]]'''''
@@ Line 31: / Line 28: @@
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 '''26 May 2023:''' ''A new page for a nacent family.'' [[Author]] '''[[User:Guanchen Liu|Guanchen Liu]]''' and [[Responsible Curator]] '''[[User:Yaoguang Chang|Yaoguang Chang]]''' completed the '''[[Glycoside Hydrolase Family 174]]''' page today.  '''[[GH174]]''' is a recently established family of (so far) bacterial alpha-1,3-L-fucanases, which was reported by [[User:Guanchen Liu|Guanchen Liu]], [[User:Yaoguang Chang|Yaoguang Chang]] and colleagues in April, following the characterization of a representative from the marine bacterium ''Wenyingzhuangia aestuarii''.  Notably, this enzyme appears to prefer sulfated fucans, and generates a highly sulfated tetrasaccharide as the main hydrolysis product.  ''Read more about this interesting enzyme and family [[GH174|here]]!''
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 '''13 April 2023:''' ''The champagne is on ice!'' We are ecstatic to report that we’ve hit 50 [[Curator Approved]] ''CAZypedia'' [[Carbohydrate Binding Module Families|CBM pages]]! The '''[[CBM92]]''' and the '''[[CBM94]]''' page were finished within under 3 hours of one another.  Congratulations to the contributors for both of the pages: new ''CAZypedia'' contibutors '''[[User:Xuanwei Mei|Xuanwei Mei]]''' and  '''[[User:Yaoguang Chang|Yaoguang Chang]]''' for the [[CBM92]] page and longtime ''CAZypedia'' contributor '''[[User:Takatsugu Miyazaki|Takatsugu Miyazaki]]''' for the [[CBM94]] page.Next stop: 100 [[Curator Approved]] [[Carbohydrate Binding Module Families|CBM pages]] (this may take a little while).

@@ Line 1: / Line 1: @@
 '''11 February 2024:''' ''A "BLAST" from the past, with a fresh update.'' [[Author]] '''[[User:Eduardo Moreno Prieto|Eduardo Moreno Prieto]]''' composed a new page on '''[[Glycoside Hydrolase Family 119]]''',a family of bacterial amylases, which was [[Curator Approved]] by '''[[User:Stefan Janecek|Stefan Janecek]]''' and '''[[User:Bernard Henrissat|Bernard Henrissat]]''' today.  The first member of '''[[GH119]]''' was characterized in 2006, and through sequence analysis with [[GH57]] members, [[User:Stefan Janecek|Janeček]] and Kuchtová predicted the active-site residues in 2012.  Over a decade later, '''[[User:Eduardo Moreno Prieto|Eduardo]]''', '''[[User:Bernard Henrissat|Bernard]]''', and colleagues finally provided critical experimental support for these predictions.  ''Learn more about this history, and especially the relationship between '''[[GH119]]''' and '''[[GH57]]''', in CAZypedia.''
 ----
 '''3 February 2024:''' ''A new family of beta-1,2-glucan-cyclizing enzymes.'' A page on the (currently) newest GH family, '''[[Glycoside Hydrolase Family 189]]''', was completed today by [[Author]]s '''[[User:Tomoko Masaike|Tomoko Masaike]]''', '''[[User:Masahiro Nakajima|Masahiro Nakajima]]''', and '''[[User:Nobukiyo Tanaka|Nobukiyo Tanaka]]''' ([[User:Masahiro Nakajima|Masahiro Nakajima]] is the [[Responsible Curator]]). '''[[GH189]]''' is a family of bacterial transglycosylases that comprise a critical domain in cyclic beta-1,2-glucan synthase (CGS), because this domain is responsible for the final cyclization step during the biosynthesis of these key effector molecules.  The discovery of '''[[GH189]]''' builds on similarly exciting work by these authors and their colleagues on beta-1,2-glucan hydrolases in [[GH144]] and [[GH162]], which share a common protein fold with '''[[GH189]]''', but have distinct mechansims. ''Check out the '''[[GH189]]''', [[GH144]], and [[GH162]] pages to learn more about this breakthrough work on beta-1,2-glucan-active enzymes!''

@@ Line 1: / Line 1: @@
 '''4 January 2024:''' ''CBM99, CBM100 and CBM101 in one fell swoop!'' Three new CBM families have been added to the ''CAZypedia'' repertoire. Though the families differ in their glycan targets, they share the interesting function of binding to highly complex sulfated marine polymers. '''[[User:Yaoguang Chang|Yaoguang Chang]]''' acted as [[Responsible Curator]] on all three pages. '''[[User:Xuanwei Mei|Xuanwei Mei]]''' [[author]]ed the [[CBM99]] and [[CBM101]] red algal specific pages and '''[[User:Guanchen Liu|Guanchen Liu]]''' authored the [[CBM100]] glycosaminoglycan specific page. ''Learn more about [[CBM99]], [[CBM100]] and [[CBM101]] on their respective pages!''
 ----
 '''4 January 2024:''' ''More "Fun" from the sea.'' Today, '''[[User:Yaoguang Chang|Yaoguang Chang]]''' [[Curator Approved]] the '''[[Glycoside Hydrolase Family 187]]''' page [[Author]]ed by '''[[User:Jingjing Shen|Jingjing Shen]]'''. The founding member of '''[[GH187]]''' is the alpha-1,3-L-fucanase ("Fun187A") the marine bacterium ''Wenyingzhuangia aestuarii'', which recognizes a specific sulfated motif in sea cucumber fucans.  '''[[GH187]]''' is a small family (<50 members) and there remains much to elucidate regarding catalytic mechanism and enzyme structure. Interest in CAZymes active on marine biomass continues to grow, and we welcome this expansion in ''CAZypedia''. ''Learn more about '''[[GH187|GH187 here!]]'''''

@@ Line 7: / Line 7: @@
 '''16 August 2023:''' ''An oldie but a goodie.'' The page for '''[[CBM9]]''', one of the original founding top 10 [[Carbohydrate Binding Module Families]], has been completed by '''[[User:Johan Larsbrink|Johan Larsbrink]]''', who multitasked as both [[Author]] and [[Responsible Curator]]. '''[[CBM9]]''' members are often found in ultra-multimodular, xylan deconstructing, bacterial enzymes, and their cellulose-binding functionality has been exploited as affinity tags in recombinant protein purifications. ''Read more on this historically important [[Carbohydrate-binding modules|CBM]] family '''[[CBM9|here]]'''!''
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 '''25 June 2023:''' ''Another one from the [https://en.wikipedia.org/wiki/Capybara capybara gut].'' We're pleased to announce that the '''[[Glycoside Hydrolase Family 173]]''' page, written by [[Author]]s '''[[User:Clelton Santos|Clelton Aparecido dos Santos]]''' and '''[[User:Gabriela Persinoti|Gabriela Felix Persinoti]]''' was [[Curator Approved]] by '''[[User:Mario Murakami|Mario Murakami]]''' today.  This new family of beta-galactosidases was created through the same study of the capybara gut metagenome by the [[User:Mario Murakami|Murakami group]]  that led to the creation of family [[CBM89]] (''see the June 22nd [[News]] item'').   '''[[GH173]]''' appears to be distantly related to [[GH5]] and [[GH30]] in [[Clan]] GH-A, yet there remain many unknowns about this family and its founding member - ''read more  [[GH173|here]]!''
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 '''23 June 2023:''' ''Human milk oligosaccharide metabolism.'' [[Author]] '''[[User:Chihaya Yamada|Chihaya Yamada]]''' and [[Responsible Curator]] '''[[User:Shinya Fushinobu|Shinya Fushinobu]]''' upgraded the '''[[Glycoside Hydrolase Family 136]]''' page to [[Curator Approved]] status today.  '''[[GH136]]''' is a family of bacterial lacto-''N''-biosidases that release lacto-''N''-biose I and lactose from lacto-N-tetraose, the main component of human milk oligosaccharides.  These enzymes have a comparatively rare right-handed beta helix fold that more typical of pectin-active [[PL]]s and [[GH]]s. ''Read more about these interesting enzymes and their role in the human gut microbiota [[GH136|here]]!''

@@ Line 1: / Line 1: @@
 '''11 January 2023:''' ''CBM44, it's what's in store.'' We begin 2023 right with a [[Curator Approved]] [[CBM44]] page.  '''[[User:Marie-Katherin Zuehlke|Marie-Katherin Zühlke]]''' has authored the page on the characterized bacterial [[CBM44]] shown to interact with polymers containing ß-1,4-linked glucose in their chains. Responsible curator [[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]] is pleased as punch.  ''Check out the '''[[CBM44]]''' CAZypedia page to learn more about this CBM family!''
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 '''25 November 2021:''' ''Something to CRO about!'' In our latest [[Curator Approved]] page in a while, '''[[User:Maria Cleveland|Maria Cleveland]]''' has written an extensive history of the Copper Radical Oxidases (CROs) that constitute '''[[Auxiliary Activity Family 5]]'''.  The archetypal '''[[AA5]]''' CRO is the ''Fusarium graminearum'' galactose oxidase, which was first isolated in the 1950s, provided the first 3-D structure in the 1990s, and has been the subject of numerous mechanistic studies up through the new millennium.  '''[[AA5]]''' also contains the glyoxal oxidases, which were discovered in Wisconsin in the late 1980s and form their own subfamily. More recent work by [[User:Maria Cleveland|Maria]], [[User:Yann Mathieu|Yann Mathieu]], and others has shown that a wider range of substrate specificities exists in this family than previously anticipated, while the catalytic flexibility of wild-type and mutant enzymes has spurred numerous biotech applications. ''Slide on over to the '''[[AA5]]''' page, which includes a <u>deep</u> reference list, to learn more about these interesting enzymes!''
 ----
 '''23 June 2021:''' ''A free CAZypedia webinar.'' Check out the presentation on ''CAZypedia'' by [[Board of Curators|Senior Curator]] [[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]], which was part of a webinar on Recent Advances in Carbohydrate-Active Enzymes organized by [[User:Stefan Janecek|Stefan Janecek]].  [[User:Stefan Janecek|Stefan]] also gave a talk on alpha-amylase bioinformatics, and Nicolas Terrapon gave an overview of the [http://www.cazy.org/ CAZy database] in a presentation entitled "Carbohydrate-Active EnZymes Annotation in the High-Throughput Era".  ''More information on the webinar can be found [https://molecules-12.sciforum.net/ here], and you can [https://youtu.be/JyV-zkr8Jw4 watch all three lectures for free on YouTube].''
@@ Line 9: / Line 21: @@
 '''31 May 2021:''' ''Celebrating CAZy.'' The [[B.A. Stone Award for Excellence in Plant Polysaccharide Biochemistry]] was awarded to [http://www.cazy.org/ CAZy] founder [[User:Bernard Henrissat|Bernard Henrissat]] today.  CAZy, ''CAZypedia'', and [[Bruce Stone|Prof. Bruce Stone]] have a [[CAZypedia:History|long, intertwined history]], and today we celebrate [[User:Bernard Henrissat|Bernie's]] insight to create a [https://doi.org/10.1042/BIO03004026 sequence-based classification of the Carbohydrate-Active EnZymes], [https://doi.org/10.1016/0378-1119(89)90339-9 starting with the cellulases].
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 '''30 March 2021:''' ''Presenting the gagalicious [[CBM87]] family.'' [[CBM87]] members are found appended to [[CE18|fungal galactosaminogalactan deacetylases]] that are involved in biofilm formation.  The [[CBM87]]s have the unusual - but not unheard of - property of extending the enzyme's catalytic site.  The GAG-binding [[CBM87]] CAZypedia page has been authored by '''[[User:Natalie Bamford|Natalie Bamford]]''' with  [[User:Lynne Howell|Lynne Howell]] acting as responsible curator.  ''Go gaga for the GAG-binding [[CBM87]] family [[CBM87|here]].''
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 '''2 December 2020:''' ''It's a bird, it's a plane, it's [[CBM14]]!'' From start to finish in superhero time, the lectin-containing, chitin-binding [[CBM14]] page is up and running. This is thanks to the heroic efforts of author '''[[User:Eva Madland|Eva Madland]]''' with  [[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]] acting as responsible curator for the [[CBM14]] page.  [[CBM14|This]] CBM family continues to blur the lines betweeen CBMs and lectins and even type [[Carbohydrate-binding_modules#Types|A]] , [[Carbohydrate-binding_modules#Types|B]]  and  [[Carbohydrate-binding_modules#Types|C]] CBMs. ''Find out more on these interesting chitin-binding multi-characteristic CBMs [[CBM14|here]].''

@@ Line 1: / Line 1: @@
-'''11 January 2023:''' ''CBM44, it's what's in store:'' We begin 2023 right with a [[Curator Approved]] [[CBM44]] page.  '''[[User:Marie-Katherin Zuehlke|Marie-Katherin Zühlke]]''' has authored the page on the characterized bacterial [[CBM44]] shown to interact with polymers containing ß-1,4-linked glucose in their chains. Responsible curator [[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]] is pleased as punch.  ''Check out the '''[[CBM44]]''' CAZypedia page to learn more about this CBM family!''
+'''11 January 2023:''' ''CBM44, it's what's in store.'' We begin 2023 right with a [[Curator Approved]] [[CBM44]] page.  '''[[User:Marie-Katherin Zuehlke|Marie-Katherin Zühlke]]''' has authored the page on the characterized bacterial [[CBM44]] shown to interact with polymers containing ß-1,4-linked glucose in their chains. Responsible curator [[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]] is pleased as punch.  ''Check out the '''[[CBM44]]''' CAZypedia page to learn more about this CBM family!''
 ----
-'''25 November 2021:''' ''Something to CRO about!:'' In our latest [[Curator Approved]] page in a while, '''[[User:Maria Cleveland|Maria Cleveland]]''' has written an extensive history of the Copper Radical Oxidases (CROs) that constitute '''[[Auxiliary Activity Family 5]]'''.  The archetypal '''[[AA5]]''' CRO is the ''Fusarium graminearum'' galactose oxidase, which was first isolated in the 1950s, provided the first 3-D structure in the 1990s, and has been the subject of numerous mechanistic studies up through the new millennium.  '''[[AA5]]''' also contains the glyoxal oxidases, which were discovered in Wisconsin in the late 1980s and form their own subfamily. More recent work by [[User:Maria Cleveland|Maria]], [[User:Yann Mathieu|Yann Mathieu]], and others has shown that a wider range of substrate specificities exists in this family than previously anticipated, while the catalytic flexibility of wild-type and mutant enzymes has spurred numerous biotech applications. ''Slide on over to the '''[[AA5]]''' page, which includes a <u>deep</u> reference list, to learn more about these interesting enzymes!''
+'''25 November 2021:''' ''Something to CRO about!'' In our latest [[Curator Approved]] page in a while, '''[[User:Maria Cleveland|Maria Cleveland]]''' has written an extensive history of the Copper Radical Oxidases (CROs) that constitute '''[[Auxiliary Activity Family 5]]'''.  The archetypal '''[[AA5]]''' CRO is the ''Fusarium graminearum'' galactose oxidase, which was first isolated in the 1950s, provided the first 3-D structure in the 1990s, and has been the subject of numerous mechanistic studies up through the new millennium.  '''[[AA5]]''' also contains the glyoxal oxidases, which were discovered in Wisconsin in the late 1980s and form their own subfamily. More recent work by [[User:Maria Cleveland|Maria]], [[User:Yann Mathieu|Yann Mathieu]], and others has shown that a wider range of substrate specificities exists in this family than previously anticipated, while the catalytic flexibility of wild-type and mutant enzymes has spurred numerous biotech applications. ''Slide on over to the '''[[AA5]]''' page, which includes a <u>deep</u> reference list, to learn more about these interesting enzymes!''
 ----
-'''23 June 2021:''' ''A free CAZypedia webinar:'' Check out the presentation on ''CAZypedia'' by [[Board of Curators|Senior Curator]] [[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]], which was part of a webinar on Recent Advances in Carbohydrate-Active Enzymes organized by [[User:Stefan Janecek|Stefan Janecek]].  [[User:Stefan Janecek|Stefan]] also gave a talk on alpha-amylase bioinformatics, and Nicolas Terrapon gave an overview of the [http://www.cazy.org/ CAZy database] in a presentation entitled "Carbohydrate-Active EnZymes Annotation in the High-Throughput Era".  ''More information on the webinar can be found [https://molecules-12.sciforum.net/ here], and you can [https://youtu.be/JyV-zkr8Jw4 watch all three lectures for free on YouTube].''
+'''23 June 2021:''' ''A free CAZypedia webinar.'' Check out the presentation on ''CAZypedia'' by [[Board of Curators|Senior Curator]] [[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]], which was part of a webinar on Recent Advances in Carbohydrate-Active Enzymes organized by [[User:Stefan Janecek|Stefan Janecek]].  [[User:Stefan Janecek|Stefan]] also gave a talk on alpha-amylase bioinformatics, and Nicolas Terrapon gave an overview of the [http://www.cazy.org/ CAZy database] in a presentation entitled "Carbohydrate-Active EnZymes Annotation in the High-Throughput Era".  ''More information on the webinar can be found [https://molecules-12.sciforum.net/ here], and you can [https://youtu.be/JyV-zkr8Jw4 watch all three lectures for free on YouTube].''
 ----
-'''31 May 2021:''' ''Celebrating CAZy:'' The [[B.A. Stone Award for Excellence in Plant Polysaccharide Biochemistry]] was awarded to [http://www.cazy.org/ CAZy] founder [[User:Bernard Henrissat|Bernard Henrissat]] today.  CAZy, ''CAZypedia'', and [[Bruce Stone|Prof. Bruce Stone]] have a [[CAZypedia:History|long, intertwined history]], and today we celebrate [[User:Bernard Henrissat|Bernie's]] insight to create a [https://doi.org/10.1042/BIO03004026 sequence-based classification of the Carbohydrate-Active EnZymes], [https://doi.org/10.1016/0378-1119(89)90339-9 starting with the cellulases].
+'''31 May 2021:''' ''Celebrating CAZy.'' The [[B.A. Stone Award for Excellence in Plant Polysaccharide Biochemistry]] was awarded to [http://www.cazy.org/ CAZy] founder [[User:Bernard Henrissat|Bernard Henrissat]] today.  CAZy, ''CAZypedia'', and [[Bruce Stone|Prof. Bruce Stone]] have a [[CAZypedia:History|long, intertwined history]], and today we celebrate [[User:Bernard Henrissat|Bernie's]] insight to create a [https://doi.org/10.1042/BIO03004026 sequence-based classification of the Carbohydrate-Active EnZymes], [https://doi.org/10.1016/0378-1119(89)90339-9 starting with the cellulases].
 ----
-'''30 March 2021:''' ''Presenting the gagalicious [[CBM87]] family:'' [[CBM87]] members are found appended to [[CE18|fungal galactosaminogalactan deacetylases]] that are involved in biofilm formation.  The [[CBM87]]s have the unusual - but not unheard of - property of extending the enzyme's catalytic site.  The GAG-binding [[CBM87]] CAZypedia page has been authored by '''[[User:Natalie Bamford|Natalie Bamford]]''' with  [[User:Lynne Howell|Lynne Howell]] acting as responsible curator.  ''Go gaga for the GAG-binding [[CBM87]] family [[CBM87|here]].''
+'''30 March 2021:''' ''Presenting the gagalicious [[CBM87]] family.'' [[CBM87]] members are found appended to [[CE18|fungal galactosaminogalactan deacetylases]] that are involved in biofilm formation.  The [[CBM87]]s have the unusual - but not unheard of - property of extending the enzyme's catalytic site.  The GAG-binding [[CBM87]] CAZypedia page has been authored by '''[[User:Natalie Bamford|Natalie Bamford]]''' with  [[User:Lynne Howell|Lynne Howell]] acting as responsible curator.  ''Go gaga for the GAG-binding [[CBM87]] family [[CBM87|here]].''
 ----
-'''2 December 2020:''' ''It's a bird, it's a plane, it's [[CBM14]]!:'' From start to finish in superhero time, the lectin-containing, chitin-binding [[CBM14]] page is up and running. This is thanks to the heroic efforts of author '''[[User:Eva Madland|Eva Madland]]''' with  [[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]] acting as responsible curator for the [[CBM14]] page.  [[CBM14|This]] CBM family continues to blur the lines betweeen CBMs and lectins and even type [[Carbohydrate-binding_modules#Types|A]] , [[Carbohydrate-binding_modules#Types|B]]  and  [[Carbohydrate-binding_modules#Types|C]] CBMs. ''Find out more on these interesting chitin-binding multi-characteristic CBMs [[CBM14|here]].''
+'''2 December 2020:''' ''It's a bird, it's a plane, it's [[CBM14]]!'' From start to finish in superhero time, the lectin-containing, chitin-binding [[CBM14]] page is up and running. This is thanks to the heroic efforts of author '''[[User:Eva Madland|Eva Madland]]''' with  [[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]] acting as responsible curator for the [[CBM14]] page.  [[CBM14|This]] CBM family continues to blur the lines betweeen CBMs and lectins and even type [[Carbohydrate-binding_modules#Types|A]] , [[Carbohydrate-binding_modules#Types|B]]  and  [[Carbohydrate-binding_modules#Types|C]] CBMs. ''Find out more on these interesting chitin-binding multi-characteristic CBMs [[CBM14|here]].''
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-'''1 December 2020:'''  ''YANCEFP! (<u>Y</u>et <u>A</u>nother <u>N</u>ew <u>C</u>arbohydrate <u>E</u>sterase <u>F</u>amily <u>P</u>age, from our friends at WLU!:'') Following on a string of CE pages completed by students at Wilfred Laurier University (see [[CE3]], [[CE4]], [[CE7]] and [[CE9]]), today '''[[User:Bobby Lamont|Bobby Lamont]]''' finalized the  '''[[Carbohydrate Esterase Family 2]]''' under the guidance of '''[[User:Joel Weadge|Prof. Joel Weadge]]''' and '''[[User:Anthony Clarke|Prof. Anthony Clarke]]'''.  '''[[CE2]]''' contains carbohydrate de-''O''-acetylases with diverse regiospecifcity, which use a catalytic dyad to perform hydrolysis.   ''This family has a long and rich history of mechanistic and structural study, dating back to the last millennium, which you can learn much more about [[Carbohydrate Esterase Family 2|on Bobby's detailed page]].''
+'''1 December 2020:'''  ''YANCEFP! (<u>Y</u>et <u>A</u>nother <u>N</u>ew <u>C</u>arbohydrate <u>E</u>sterase <u>F</u>amily <u>P</u>age, from our friends at WLU!'') Following on a string of CE pages completed by students at Wilfred Laurier University (see [[CE3]], [[CE4]], [[CE7]] and [[CE9]]), today '''[[User:Bobby Lamont|Bobby Lamont]]''' finalized the  '''[[Carbohydrate Esterase Family 2]]''' under the guidance of '''[[User:Joel Weadge|Prof. Joel Weadge]]''' and '''[[User:Anthony Clarke|Prof. Anthony Clarke]]'''.  '''[[CE2]]''' contains carbohydrate de-''O''-acetylases with diverse regiospecifcity, which use a catalytic dyad to perform hydrolysis.   ''This family has a long and rich history of mechanistic and structural study, dating back to the last millennium, which you can learn much more about [[Carbohydrate Esterase Family 2|on Bobby's detailed page]].''
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-'''29 September 2020:''' ''Back to the future with beta-1,3-glucanases:'' The '''[[Glycoside Hydrolase Family 128]]''' page was promoted to [[Curator Approved]] status by '''[[User:Mario Murakami|Mario Murakami]]''' today.  '''[[GH128]]''' was originally created following the discovery of this family by '''[[User:Yuichi Sakamoto|Yuichi Sakamoto]]''' and colleagues, who characterized the archetypal beta-1,3-glucanase from the  shiitake mushroom.  This year, a team led by '''[[User:Mario Murakami|Mario Murakami]]''', including first-author '''[[User:Camila Santos|Camila Santos]]''', presented a sweeping first mechanistic and structural study of '''[[GH128]]'''.  ''We're grateful to '''[[User:Camila Santos|Camila]]''' and '''[[User:Mario Murakami|Mario]]''' for elaborating upon '''[[User:Yuichi Sakamoto|Yuichi's]]''' original CAZypedia page, which you can read [[Glycoside Hydrolase Family 128|here]]. You can also compare '''[[GH128]]''' with other distinct beta-1,3-glucanase families covered in CAZypedia, e.g. [[GH17]], [[GH81]], [[GH148]], and [[GH158]].''
+'''29 September 2020:''' ''Back to the future with beta-1,3-glucanases.'' The '''[[Glycoside Hydrolase Family 128]]''' page was promoted to [[Curator Approved]] status by '''[[User:Mario Murakami|Mario Murakami]]''' today.  '''[[GH128]]''' was originally created following the discovery of this family by '''[[User:Yuichi Sakamoto|Yuichi Sakamoto]]''' and colleagues, who characterized the archetypal beta-1,3-glucanase from the  shiitake mushroom.  This year, a team led by '''[[User:Mario Murakami|Mario Murakami]]''', including first-author '''[[User:Camila Santos|Camila Santos]]''', presented a sweeping first mechanistic and structural study of '''[[GH128]]'''.  ''We're grateful to '''[[User:Camila Santos|Camila]]''' and '''[[User:Mario Murakami|Mario]]''' for elaborating upon '''[[User:Yuichi Sakamoto|Yuichi's]]''' original CAZypedia page, which you can read [[Glycoside Hydrolase Family 128|here]]. You can also compare '''[[GH128]]''' with other distinct beta-1,3-glucanase families covered in CAZypedia, e.g. [[GH17]], [[GH81]], [[GH148]], and [[GH158]].''
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+'''22 September 2020:''' ''Like PLs, but different.'' We are happy to announce the completion of a new [[Lexicon]] page on [[Polysaccharide epimerases]] today.  '''[[User:Margrethe Gaardlos|Margrethe Gaardlos]]''' spearheaded the composition of this new page, with input from co-[[author]] '''[[User:Anne Tondervik|Anne Tøndervik]]''' and [[Responsible Curator]] '''[[User:Finn Aachmann|Finn Lillelund Aachmann]]'''.  Although they are not categorized into families in the CAZy system, '''[[Polysaccharide epimerases]]''' bear a lot of structural and mechanistic similarity to '''[[Polysaccharide Lyases]]''':  Instead of catalyzing an elimination reaction to break poly-uronic acid chains, '''[[Polysaccharide epimerases]]''' simply use the first part of the [[PL]] mechanism to remove and re-add the C-5 proton.  The resulting change in the configuration of the C-6 carboxylate has major impacts on polysaccharide structure and properties.  ''The Norwegian team has done a tremendous job in capturing the broad history of these enzymes, including their diverse substrate specificities and structures (and over 130 references!), which you can read all about [[Polysaccharide epimerases|here.]]''  (We also thank [[User:Mirjam Czjzek|Mirjam Czjzek]] for championing the inclusion of the "PEs" in ''CAZYpedia''.)
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-'''6 August 2020:''' ''A beta-1,3-glucanase family with a deep history:'' '''[[User:Julie Grondin|Julie Grondin's]]''' '''[[Glycoside Hydrolase Family 81]]''' page was [[Curator Approved]] by '''[[User:Al Boraston|Al Boraston]]''' today.  '''[[GH81]]''' has a long history of discovery and mechanistic study, including by original CAZypedian and [https://www.grc.org/carbohydrate-active-enzymes-for-glycan-conversions-conference/default.aspx Cellulase/CAZyme GRC co-founder] '''[[User:David Wilson|David Wilson]]''' and co-workers.  By capturing a phenomenal number of oligosaccharide complexes, '''[[User:Al Boraston|Al's]]''' group has recently provided detailed molecular description of how enzymes in this family specifically recognize the helical structure adopted by beta-1,3-glucans. ''Be sure to check out the [[Glycoside Hydrolase Family 81|GH81 page]] to get the full history of the contributions of a number of groups world-wide to our knowledge of this family.''
+'''6 August 2020:''' ''A beta-1,3-glucanase family with a deep history.'' '''[[User:Julie Grondin|Julie Grondin's]]''' '''[[Glycoside Hydrolase Family 81]]''' page was [[Curator Approved]] by '''[[User:Al Boraston|Al Boraston]]''' today.  '''[[GH81]]''' has a long history of discovery and mechanistic study, including by original CAZypedian and [https://www.grc.org/carbohydrate-active-enzymes-for-glycan-conversions-conference/default.aspx Cellulase/CAZyme GRC co-founder] '''[[User:David Wilson|David Wilson]]''' and co-workers.  By capturing a phenomenal number of oligosaccharide complexes, '''[[User:Al Boraston|Al's]]''' group has recently provided detailed molecular description of how enzymes in this family specifically recognize the helical structure adopted by beta-1,3-glucans. ''Be sure to check out the [[Glycoside Hydrolase Family 81|GH81 page]] to get the full history of the contributions of a number of groups world-wide to our knowledge of this family.''
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 '''23 July 2020:''' ''Another CE family page from our friends at WLU!'' The '''[[Carbohydrate Esterase Family 7]]''' page was finalized and promoted to [[Curator Approved]] status today.  '''[[User:Joel Weadge|Joel Weadge]]''' and '''[[User:Joel Weadge|Michael Suits]]''' have been leading the completion of a bunch of CE pages with the help of keen students from Wilfred Laurier University (see [[CE3]], [[CE4]], and [[CE9]]).  This time, '''[[User:Emily Rodriguez|Emily Rodriguez]]''' produced the '''[[CE7]]''' page, which encompasses acetyl xylan esterases and cephalosporin-C deacetylases.  ''Learn more about the specificity, mechanism, and three-dimensional structure of CE7 enzymes [[Carbohydrate Esterase Family 7|here]].''