User:Kim Orth - Revision history

Wei Peng at 19:08, 10 December 2025

2025-12-10T19:08:39Z

Wei Peng at 05:13, 9 December 2025

2025-12-09T05:13:36Z

Wei Peng at 05:11, 9 December 2025

2025-12-09T05:11:43Z

Wei Peng at 05:10, 9 December 2025

2025-12-09T05:10:50Z

Wei Peng at 19:43, 8 December 2025

2025-12-08T19:43:51Z

Wei Peng at 19:43, 8 December 2025

2025-12-08T19:43:13Z

Wei Peng at 19:41, 8 December 2025

2025-12-08T19:41:50Z

Wei Peng at 19:41, 8 December 2025

2025-12-08T19:41:03Z

Wei Peng at 19:39, 8 December 2025

2025-12-08T19:39:30Z

Harry Brumer: Created page with "right '''This is an empty template to help you get started with composing your User page.''' You should begin by opening this page for ed..."

2024-12-10T16:01:38Z

Created page with "200px|right '''This is an empty template to help you get started with composing your User page.''' You should begin by opening this page for ed..."

New page

[[Image:Blank_user-200px.png|200px|right]]
'''This is an empty template to help you get started with composing your User page.'''

You should begin by opening this page for editing by clicking on the Edit tab above. Your biography goes in this area of the page.

* See [[User:Gerlind_Sulzenbacher]] for an example. You may copy text from this example by opening the page in another browser window and clicking the "Edit" tab.
* Add your publications in the list below using PubMed IDs and cite them in the text like this <cite>Gilbert2008</cite>.
* Please upload a picture of yourself using the "Upload file" link in the Toolbox section of the left menu, and then replace the Image filename with your own.

''More specific help on these steps is available from the links under the "For contributors" section of the left page menu.''

----

<biblio>
#Gilbert2008 pmid=18430603

</biblio>


[[Category:Contributors|Orth,Kim]]

← Older revision		Revision as of 19:08, 10 December 2025
Line 3:		Line 3:

	The Orth Lab is interested in elucidation the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems. They have discovered novel chemistry, including Ser/Thr acetylation and AMPylation, used by bacterial virulence factors to manipulate the host cell signaling. In some cases, they found the eukaryotic host also uses these novel mechanisms.		The Orth Lab is interested in elucidation the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems. They have discovered novel chemistry, including Ser/Thr acetylation and AMPylation, used by bacterial virulence factors to manipulate the host cell signaling. In some cases, they found the eukaryotic host also uses these novel mechanisms.
−
−	The marine bacterium ''Vibrio parahaemolyticus'' is the worldwide leading cause of seafood-borne acute gastroenteritis. The Orth Lab is working on the two ''V. parahaemolyticus'' type 3 secretion systems (T3SS1 and T3SS2) and their bacterial effectors to understand how signaling systems in the eukaryotic host can be manipulated by these bacterial pathogens. For decades, this pathogen has been studied exclusively as an extracellular bacterium. However, recent studies from our lab have revealed the pathogen’s ability to invade and replicate within host cells using the second T3SS2. New host mechanisms that are exploited by this bacterium to survive and escape. Work in the Orth Lab at UT Southwestern is accomplished using a broad range of tools, including biochemistry, molecular microbiology, protein chemistry, structural biology, yeast genetics, cell biology, biophysics and more.

	The Orth lab discovered that the bacterial effector protein AvrB is an unprecedented glycosyltransferase <cite>Peng2024</cite>. AvrB contains a domain or fold called Fido <cite>Kinch2009</cite>. AvrB catalyzes the transfer of rhamnose from UDP-rhamnose to a threonine residue of its protein substrate in host cells <cite>Peng2024</cite>. '''AvrB is the founding member of glycosyltransferases with Fido fold''', belonging to family of [[GT138]].		The Orth lab discovered that the bacterial effector protein AvrB is an unprecedented glycosyltransferase <cite>Peng2024</cite>. AvrB contains a domain or fold called Fido <cite>Kinch2009</cite>. AvrB catalyzes the transfer of rhamnose from UDP-rhamnose to a threonine residue of its protein substrate in host cells <cite>Peng2024</cite>. '''AvrB is the founding member of glycosyltransferases with Fido fold''', belonging to family of [[GT138]].

@@ Line 1: / Line 1: @@
 [[Image:Kim-Orth.png|150px|right]]
-Kim Orth is a '''Professor of Molecular Biology and Biochemistry at UT Southwestern Medical Center''' and is an '''Investigator for the Howard Hughes Medical Institute'''. She is a W. W. Caruth, Jr. Scholar in Biomedical Research and holds the Earl A. Forsythe Chair in Biomedical Science.
+Kim Orth is a Professor of Molecular Biology and Biochemistry at UT Southwestern Medical Center and is an Investigator for the Howard Hughes Medical Institute. She is a W. W. Caruth, Jr. Scholar in Biomedical Research and holds the Earl A. Forsythe Chair in Biomedical Science.
 The Orth Lab is interested in elucidation the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems. They have discovered novel chemistry, including Ser/Thr acetylation and AMPylation, used by bacterial virulence factors to manipulate the host cell signaling. In some cases, they found the eukaryotic host also uses these novel mechanisms.

@@ Line 1: / Line 1: @@
 [[Image:Kim-Orth.png|150px|right]]
-Kim Orth is a Professor of '''Molecular Biology and Biochemistry''' at '''UT Southwestern Medical Center''' and is an Investigator for the '''Howard Hughes Medical Institute'''. She is a W. W. Caruth, Jr. Scholar in Biomedical Research and holds the Earl A. Forsythe Chair in Biomedical Science.
+Kim Orth is a '''Professor of Molecular Biology and Biochemistry at UT Southwestern Medical Center''' and is an '''Investigator for the Howard Hughes Medical Institute'''. She is a W. W. Caruth, Jr. Scholar in Biomedical Research and holds the Earl A. Forsythe Chair in Biomedical Science.
 The Orth Lab is interested in elucidation the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems. They have discovered novel chemistry, including Ser/Thr acetylation and AMPylation, used by bacterial virulence factors to manipulate the host cell signaling. In some cases, they found the eukaryotic host also uses these novel mechanisms.

@@ Line 1: / Line 1: @@
 [[Image:Kim-Orth.png|150px|right]]
-Kim Orth is a Professor of Molecular Biology and Biochemistry and is an Investigator for the Howard Hughes Medical Institute. She is a W. W. Caruth, Jr. Scholar in Biomedical Research and holds the Earl A. Forsythe Chair in Biomedical Science.
+Kim Orth is a Professor of '''Molecular Biology and Biochemistry''' at '''UT Southwestern Medical Center''' and is an Investigator for the '''Howard Hughes Medical Institute'''. She is a W. W. Caruth, Jr. Scholar in Biomedical Research and holds the Earl A. Forsythe Chair in Biomedical Science.
 The Orth Lab is interested in elucidation the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems. They have discovered novel chemistry, including Ser/Thr acetylation and AMPylation, used by bacterial virulence factors to manipulate the host cell signaling. In some cases, they found the eukaryotic host also uses these novel mechanisms.

← Older revision		Revision as of 19:43, 8 December 2025
Line 1:		Line 1:
−	[[Image:Kim-Orth.png\|~~200px~~\|right]]	+	[[Image:Kim-Orth.png\|150px\|right]]
	Kim Orth is a Professor of Molecular Biology and Biochemistry and is an Investigator for the Howard Hughes Medical Institute. She is a W. W. Caruth, Jr. Scholar in Biomedical Research and holds the Earl A. Forsythe Chair in Biomedical Science.		Kim Orth is a Professor of Molecular Biology and Biochemistry and is an Investigator for the Howard Hughes Medical Institute. She is a W. W. Caruth, Jr. Scholar in Biomedical Research and holds the Earl A. Forsythe Chair in Biomedical Science.

@@ Line 4: / Line 4: @@
 The Orth Lab is interested in elucidation the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems. They have discovered novel chemistry, including Ser/Thr acetylation and AMPylation, used by bacterial virulence factors to manipulate the host cell signaling. In some cases, they found the eukaryotic host also uses these novel mechanisms.
-The marine bacterium Vibrio parahaemolyticus is the worldwide leading cause of seafood-borne acute gastroenteritis. The Orth Lab is working on the two V. parahaemolyticus type 3 secretion systems (T3SS1 and T3SS2) and their bacterial effectors to understand how signaling systems in the eukaryotic host can be manipulated by these bacterial pathogens. For decades, this pathogen has been studied exclusively as an extracellular bacterium. However, recent studies from our lab have revealed the pathogen’s ability to invade and replicate within host cells using the second T3SS2. New host mechanisms that are exploited by this bacterium to survive and escape. Work in the Orth Lab at UT Southwestern is accomplished using a broad range of tools, including biochemistry, molecular microbiology, protein chemistry, structural biology, yeast genetics, cell biology, biophysics and more.
+The marine bacterium ''Vibrio parahaemolyticus'' is the worldwide leading cause of seafood-borne acute gastroenteritis. The Orth Lab is working on the two ''V. parahaemolyticus'' type 3 secretion systems (T3SS1 and T3SS2) and their bacterial effectors to understand how signaling systems in the eukaryotic host can be manipulated by these bacterial pathogens. For decades, this pathogen has been studied exclusively as an extracellular bacterium. However, recent studies from our lab have revealed the pathogen’s ability to invade and replicate within host cells using the second T3SS2. New host mechanisms that are exploited by this bacterium to survive and escape. Work in the Orth Lab at UT Southwestern is accomplished using a broad range of tools, including biochemistry, molecular microbiology, protein chemistry, structural biology, yeast genetics, cell biology, biophysics and more.
 The Orth lab discovered that the bacterial effector protein AvrB is an unprecedented glycosyltransferase <cite>Peng2024</cite>. AvrB contains a domain or fold called Fido <cite>Kinch2009</cite>. AvrB catalyzes the transfer of rhamnose from UDP-rhamnose to a threonine residue of its protein substrate in host cells <cite>Peng2024</cite>. '''AvrB is the founding member of glycosyltransferases with Fido fold''', belonging to family of [[GT138]].

← Older revision		Revision as of 19:41, 8 December 2025
Line 1:		Line 1:
−	[[Image:Kim-Orth.png\|~~150px~~\|right]]	+	[[Image:Kim-Orth.png\|200px\|right]]
	Kim Orth is a Professor of Molecular Biology and Biochemistry and is an Investigator for the Howard Hughes Medical Institute. She is a W. W. Caruth, Jr. Scholar in Biomedical Research and holds the Earl A. Forsythe Chair in Biomedical Science.		Kim Orth is a Professor of Molecular Biology and Biochemistry and is an Investigator for the Howard Hughes Medical Institute. She is a W. W. Caruth, Jr. Scholar in Biomedical Research and holds the Earl A. Forsythe Chair in Biomedical Science.

@@ Line 1: / Line 1: @@
-[[Image:Blank_user-200px.png|200px|right]]
+[[Image:Kim-Orth.jpeg|150px|right]]
-'''This is an empty template to help you get started with composing your User page.'''
+Kim Orth is a Professor of Molecular Biology and Biochemistry and is an Investigator for the Howard Hughes Medical Institute. She is a W. W. Caruth, Jr. Scholar in Biomedical Research and holds the Earl A. Forsythe Chair in Biomedical Science.
-You should begin by opening this page for editing by clicking on the Edit tab above.  Your biography goes in this area of the page.
+The Orth Lab is interested in elucidation the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems. They have discovered novel chemistry, including Ser/Thr acetylation and AMPylation, used by bacterial virulence factors to manipulate the host cell signaling. In some cases, they found the eukaryotic host also uses these novel mechanisms.
-* See [[User:Gerlind_Sulzenbacher]] for an example.  You may copy text from this example by opening the page in another browser window and clicking the "Edit" tab.
+The marine bacterium Vibrio parahaemolyticus is the worldwide leading cause of seafood-borne acute gastroenteritis. The Orth Lab is working on the two V. parahaemolyticus type 3 secretion systems (T3SS1 and T3SS2) and their bacterial effectors to understand how signaling systems in the eukaryotic host can be manipulated by these bacterial pathogens. For decades, this pathogen has been studied exclusively as an extracellular bacterium. However, recent studies from our lab have revealed the pathogen’s ability to invade and replicate within host cells using the second T3SS2. New host mechanisms that are exploited by this bacterium to survive and escape. Work in the Orth Lab at UT Southwestern is accomplished using a broad range of tools, including biochemistry, molecular microbiology, protein chemistry, structural biology, yeast genetics, cell biology, biophysics and more.
-''More specific help on these steps is available from the links under the "For contributors" section of the left page menu.''
+The Orth lab discovered that the bacterial effector protein AvrB is an unprecedented glycosyltransferase <cite>Peng2024</cite>. AvrB contains a domain or fold called Fido <cite>Kinch2009</cite>. AvrB catalyzes the transfer of rhamnose from UDP-rhamnose to a threonine residue of its protein substrate in host cells <cite>Peng2024</cite>. '''AvrB is the founding member of glycosyltransferases with Fido fold''', belonging to family of [[GT138]].
@@ Line 15: / Line 16: @@
 <biblio>
-#Gilbert2008 pmid=18430603
+#Peng2024 pmid=38354245
 </biblio>
 <!-- Do not remove this Category tag -->
-[[Category:Contributors|Orth,Kim]]
+[[Category:Contributors|Peng,Wei]]