User:Lynne Howell - Revision history

Natalie Bamford at 15:53, 15 September 2020

2020-09-15T15:53:27Z

Natalie Bamford at 10:03, 15 September 2020

2020-09-15T10:03:04Z

Natalie Bamford at 09:11, 15 September 2020

2020-09-15T09:11:29Z

Harry Brumer: Created page with "right '''This is an empty template to help you get started with composing your User page.''' You should begin by opening this page for ed..."

2020-05-28T16:18:31Z

Created page with "200px|right '''This is an empty template to help you get started with composing your User page.''' You should begin by opening this page for ed..."

New page

[[Image:Blank_user-200px.png|200px|right]]
'''This is an empty template to help you get started with composing your User page.'''

You should begin by opening this page for editing by clicking on the Edit tab above. Your biography goes in this area of the page.

* See [[User:Gerlind_Sulzenbacher]] for an example. You may copy text from this example by opening the page in another browser window and clicking the "Edit" tab.
* Add your publications in the list below using PubMed IDs and cite them in the text like this <cite>Gilbert2008</cite>.
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----

<biblio>
#Gilbert2008 pmid=18430603

</biblio>


[[Category:Contributors|Howell,Lynne]]

@@ Line 1: / Line 1: @@
-[[Image:LynneHowell.jpg|200px|right]]
+[[Image:Howell_Lynne_new.jpeg|200px|right]]
 '''Lynne Howell''' obtained an undergraduate degree in Biophysics from the [https://www.leeds.ac.uk/ University of Leeds] in 1983 and a Ph.D. in Crystallography from the [https://london.ac.uk/ University of London] under the guidance of Prof. Dame Jane Goodfellow. She spent three years as a postdoctoral fellow with [https://petskolab.bwh.harvard.edu/ Professor Gregory Petsko] at the [https://www.mit.edu/ Massachusetts Institute of Technology] before moving to Paris to study with Dr. Roberto Poljak and Dr. André Menez at the [https://www.pasteur.fr/en Institut Pasteur]. After a year as a staff scientist in Paris, Dr. Howell  joined [https://www.sickkids.ca/Research/Molecular-Medicine/index.html The Hospital of Sick Children] in Toronto in late 1991 and was cross appointed to the [https://www.utoronto.ca/ University of Toronto] shortly thereafter. She’s a recipient of a Canada Research Chair in Structural Biology and her research is focused on microbial biofilm formation, specifically understanding at the molecular level the exopolysaccharide biosynthetic systems of various bacteria and fungi (more information can be found on the [https://lab.research.sickkids.ca/howell/ laboratory webpage]). This work has involved collaborations with [[User: Anthony Clarke|Prof. Anthony Clarke]], [https://sites.chem.utoronto.ca/nitz/ Prof. Mark Nitz], [https://www.universiteitleiden.nl/en/staffmembers/jeroen-codee#tab-1 Prof. Jeroen Codée], [http://klassengroup.ca/ Prof. John Klassen], [https://www.mcgill.ca/microimm/donald-sheppard Prof. Don Sheppard] and [[User: Joel Weadge|Prof. Joel Weadge]], among others.
@@ Line 7: / Line 7: @@
 *[[Glycoside Hydrolase Family 39|GH39]] ''Pseudomonas aeruginosa'' PslG, PSL polysaccharide hydrolase <cite>Baker2015</cite>
 *[[Glycoside Hydrolase Family 47|GH47]] ''Penicillium citrinum'' α-1,2-mannosidase <cite>Lobsanov2002</cite>
-*[[Glycoside Hydrolase Family 114|GH114]] ''Aspergillus fumigatus'' Ega3, an α-1,4-galactosaminidase <cite>Bamford2019</cite>
+*[[Glycoside Hydrolase Family 114|GH114]] ''Aspergillus fumigatus''&nbsp;Ega3, an α-1,4-galactosaminidase <cite>Bamford2019</cite>
-*[[Glycoside Hydrolase Family 135|GH135]] ''Aspergillus clavatus'' Sph3, an α-1,4-N-acetylgalactosaminidase  <cite>Bamford2015</cite>
+*[[Glycoside Hydrolase Family 135|GH135]]&nbsp;''Aspergillus clavatus''&nbsp;Sph3, an α-1,4-N-acetylgalactosaminidase &nbsp;<cite>Bamford2015</cite>
-*[[Glycoside Hydrolase Family 153|GH153]] ''Bordetella bronchiseptica'' PgaB (C-terminal domain), a poly-β-1,6-D-glucosamine hydrolase <cite>Little2018</cite>
+*[[Glycoside Hydrolase Family 153|GH153]]&nbsp;''Bordetella bronchiseptica''&nbsp;PgaB (C-terminal domain), a poly-β-1,6-D-glucosamine hydrolase <cite>Little2018</cite>
 *[[Glycoside Hydrolase Family 166|GH166]] ''Pseudomonas aeruginosa'' PelA (N-terminal domain), α-1,4-N-acetylgalactosaminidase <cite>LeMauff2019</cite>
-*[[Carbohydrate Esterase Family 4|CE4]] ''Ammonifex degensii'' IcaB, a poly-β-1,6-N-acetyl-D-glucosamine deacetylase <cite>Little2014</cite>
+*[[Carbohydrate Esterase Family 4|CE4]]&nbsp;''Ammonifex degensii''&nbsp;IcaB, a poly-β-1,6-N-acetyl-D-glucosamine deacetylase <cite>Little2014</cite>&nbsp;
-*[[Carbohydrate Esterase Family 4|CE4]] ''Bordetella bronchiseptica'' PgaB (N-terminal domain), a poly-β-1,6-N-acetyl-D-glucosamine deacetylase <cite>Little2015</cite>
+*[[Carbohydrate Esterase Family 4|CE4]]&nbsp;''Bordetella bronchiseptica''&nbsp;PgaB (N-terminal domain), a poly-β-1,6-N-acetyl-D-glucosamine deacetylase <cite>Little2015</cite>
 *[[Carbohydrate Esterase Family 4|CE4]]/[[Glycoside Hydrolase Family 153|GH153]] ''Escherichia coli'' PgaB, a poly-β-1,6-D-glucosamine deacetylase and hydrolase <cite>Little2014b</cite>
-*[[CE18]] and [[Carbohydrate Binding Module Family 87|CBM87]] ''Aspergillus fumigatus'' Agd3, an α-1,4-N-acetylgalactosaminidase deacetylase <cite>Bamford2020</cite>
+*[[CE18]]&nbsp;and&nbsp;[[Carbohydrate Binding Module Family 87|CBM87]]&nbsp;''Aspergillus fumigatus''&nbsp;Agd3, an α-1,4-N-acetylgalactosaminidase deacetylase <cite>Bamford2020</cite>&nbsp;
 *PL5 ''Pseudomonas aeruginosa'' AlgL, (no associated paper)
 *[[Polysaccharide Lyase Family 7|PL7]] ''Klebsiella pneumoniae'' Alginate lyase, (no associated paper)

@@ Line 12: / Line 12: @@
 *[[Glycoside Hydrolase Family 166|GH166]] ''Pseudomonas aeruginosa'' PelA (N-terminal domain), α-1,4-N-acetylgalactosaminidase <cite>LeMauff2019</cite>
 *[[Carbohydrate Esterase Family 4|CE4]] ''Ammonifex degensii'' IcaB, a poly-β-1,6-N-acetyl-D-glucosamine deacetylase <cite>Little2014</cite>
-*[[Carbohydrate Esterase Family 4|CE4]] ''Bordetella bronchiseptica'' PgaB (N-terminal domain), a poly-β-1,6-N-acetyl-D-glucosamine deacetylase <cite>Little2018</cite>
+*[[Carbohydrate Esterase Family 4|CE4]] ''Bordetella bronchiseptica'' PgaB (N-terminal domain), a poly-β-1,6-N-acetyl-D-glucosamine deacetylase <cite>Little2015</cite>
 *[[Carbohydrate Esterase Family 4|CE4]]/[[Glycoside Hydrolase Family 153|GH153]] ''Escherichia coli'' PgaB, a poly-β-1,6-D-glucosamine deacetylase and hydrolase <cite>Little2014b</cite>
 *[[CE18]] and [[Carbohydrate Binding Module Family 87|CBM87]] ''Aspergillus fumigatus'' Agd3, an α-1,4-N-acetylgalactosaminidase deacetylase <cite>Bamford2020</cite>
@@ Line 37: / Line 37: @@
 #LeMauff2019 pmid=31167793
 #Little2014 pmid=25359777
-#Little2018 pmid=29684093
+#Little2015 pmid=26203190
 #Little2014b pmid=24994902
 #Bamford2020 pmid=32415073

@@ Line 1: / Line 1: @@
-[[Image:Blank_user-200px.png|200px|right]]
+[[Image:LynneHowell.jpg|200px|right]]
-You should begin by opening this page for editing by clicking on the Edit tab above.  Your biography goes in this area of the page.
+'''Lynne Howell''' obtained an undergraduate degree in Biophysics from the [https://www.leeds.ac.uk/ University of Leeds] in 1983 and a Ph.D. in Crystallography from the [https://london.ac.uk/ University of London] under the guidance of Prof. Dame Jane Goodfellow. She spent three years as a postdoctoral fellow with [https://petskolab.bwh.harvard.edu/ Professor Gregory Petsko] at the [https://www.mit.edu/ Massachusetts Institute of Technology] before moving to Paris to study with Dr. Roberto Poljak and Dr. André Menez at the [https://www.pasteur.fr/en Institut Pasteur]. After a year as a staff scientist in Paris, Dr. Howell  joined [https://www.sickkids.ca/Research/Molecular-Medicine/index.html The Hospital of Sick Children] in Toronto in late 1991 and was cross appointed to the [https://www.utoronto.ca/ University of Toronto] shortly thereafter. She’s a recipient of a Canada Research Chair in Structural Biology and her research is focused on microbial biofilm formation, specifically understanding at the molecular level the exopolysaccharide biosynthetic systems of various bacteria and fungi (more information can be found on the [https://lab.research.sickkids.ca/howell/ laboratory webpage]). This work has involved collaborations with [[User: Anthony Clarke|Prof. Anthony Clarke]], [https://sites.chem.utoronto.ca/nitz/ Prof. Mark Nitz], [https://www.universiteitleiden.nl/en/staffmembers/jeroen-codee#tab-1 Prof. Jeroen Codée], [http://klassengroup.ca/ Prof. John Klassen], [https://www.mcgill.ca/microimm/donald-sheppard Prof. Don Sheppard] and [[User: Joel Weadge|Prof. Joel Weadge]], among others.
-* See [[User:Gerlind_Sulzenbacher]] for an example.  You may copy text from this example by opening the page in another browser window and clicking the "Edit" tab.
+Her lab has determined the crystal structures of multiple carbohydrate active enzymes including (but not limited to):
@@ Line 15: / Line 30: @@
 <biblio>
-#Gilbert2008 pmid=18430603
+#Baker2015 pmid=26424791
 </biblio>