User:Nobukiyo Tanaka - Revision history

Harry Brumer at 16:27, 26 February 2024

2024-02-26T16:27:55Z

Harry Brumer: minor formatting and link changes

2024-02-26T16:27:15Z

minor formatting and link changes

Nobukiyo Tanaka at 04:08, 11 February 2024

2024-02-11T04:08:43Z

Nobukiyo Tanaka at 07:13, 9 February 2024

2024-02-09T07:13:44Z

Nobukiyo Tanaka at 06:56, 8 February 2024

2024-02-08T06:56:17Z

Nobukiyo Tanaka at 06:53, 8 February 2024

2024-02-08T06:53:23Z

Nobukiyo Tanaka at 06:52, 8 February 2024

2024-02-08T06:52:05Z

Nobukiyo Tanaka at 06:51, 8 February 2024

2024-02-08T06:51:28Z

Nobukiyo Tanaka at 06:46, 8 February 2024

2024-02-08T06:46:41Z

Nobukiyo Tanaka at 06:40, 8 February 2024

2024-02-08T06:40:24Z

@@ Line 1: / Line 1: @@
 [[Image:Nobukiyo_Tanaka.jpg |200px|right]]
-Nobukiyo Tanaka received a Ph.Dr. in Science from Tokyo University of Science under the supervision of Dr. Hayao Taguchi and [[User:Masahiro Nakajima|Dr. Masahiro Nakajima]] in 2019. He is currently an assistant professor at the same university.
+Nobukiyo Tanaka received a Ph.D. in Science from Tokyo University of Science under the supervision of Dr. Hayao Taguchi and [[User:Masahiro Nakajima|Dr. Masahiro Nakajima]] in 2019. He is currently an Assistant Professor at the same university.
 === Creation of the new GH162 and GH189 families (Family first) ===

@@ Line 1: / Line 1: @@
 [[Image:Nobukiyo_Tanaka.jpg |200px|right]]
-Nobukiyo Tanaka received a Ph.Dr. in Science from Tokyo University of Science under the supervision of Dr. Hayao Taguchi and Dr. Masahiro Nakajima in 2019. He is currently an assistant professor at the same university.
+Nobukiyo Tanaka received a Ph.Dr. in Science from Tokyo University of Science under the supervision of Dr. Hayao Taguchi and [[User:Masahiro Nakajima|Dr. Masahiro Nakajima]] in 2019. He is currently an assistant professor at the same university.
-=== '''Creation of a new GH162 and GH189 family (Family first)''' ===
+=== Creation of the new GH162 and GH189 families (Family first) ===
-He has identified and characterized ''Talaromyces funiculosus'' ''endo''-β-1,2-glucanase (TfSGL) and determined its 3D structures. TfSGL does not share any homology with known glycoside hydrolases (GHs). He demonstrated that the reaction mechanism of TfSGL shows clear differences in the reaction pathways from those of GH enzymes. This leads to the classification of the TfSGL group as a new GH family 162 <cite>Tanaka2019</cite>.
+He has identified and characterized ''Talaromyces funiculosus'' ''endo''-β-1,2-glucanase (TfSGL) and determined its 3D structures. TfSGL does not share any homology with known glycoside hydrolases (GHs). He demonstrated that the reaction mechanism of TfSGL shows clear differences in the reaction pathways from those of GH enzymes. This leads to the classification of the TfSGL group as a new GH family, [[GH162]] <cite>Tanaka2019</cite>.
-Furthermore, in 2024, he performed functional and structural analyses of the cyclization domain of CGS alone from ''Thermoanaerobacter italicus'' (TiCGS<sub>Cy</sub>), identified catalytic residues, and determined its 3D structures. This study showed that TiCGS<sub>Cy</sub> exhibits low sequence homology with known GH enzymes and possesses a unique catalytic reaction mechanism. Consequently, the CGSs group is defined as a new GH family 189 <cite>Tanaka2024</cite>.
+Furthermore, in 2024, he performed functional and structural analyses of the cyclization domain of CGS alone from ''Thermoanaerobacter italicus'' (TiCGS<sub>Cy</sub>), identified catalytic residues, and determined its 3D structures. This study showed that TiCGS<sub>Cy</sub> exhibits low sequence homology with known GH enzymes and possesses a unique catalytic reaction mechanism. Consequently, the CGSs group is defined as a new GH family, [[GH189]] <cite>Tanaka2024</cite>.
-=== '''Establishment of a new clan GH-S (Clan first)''' ===
+=== Establishment of a new clan GH-S (Clan first) ===
-He revealed that the overall structure of TfSGL, which has a (α/α)<sub>6</sub> fold, is similar to that of a prokaryotic ''endo''-β-1,2-glucanase (CpSGL, belonging to GH144), and one of the catalytic residues overlaps significantly. This finding suggested that TfSGL (GH162) and CpSGL (GH144) constitute a new clan, GH-S <cite>Tanaka2019, Abe2017, Tanaka2024</cite>.
+He revealed that the overall structure of TfSGL, which has a (α/α)<sub>6</sub> fold, is similar to that of a prokaryotic ''endo''-β-1,2-glucanase (CpSGL, belonging to [[GH144]]), and one of the catalytic residues overlaps significantly. This finding suggested that TfSGL ([[GH162]]) and CpSGL ([[GH144]]) constitute a new clan, GH-S <cite>Tanaka2019, Abe2017, Tanaka2024</cite>.
 * [[GH162]]: ''endo''-&beta;-1,2-glucanase from ''Talaromyces funiculosus'' <cite>Tanaka2019</cite>
 * [[GH189]]: The cyclization domain alone of cyclic β-1,2-glucan synthase from ''Thermoanaerobacter italicus'' <cite>Tanaka2024</cite>
-* Related families of a new clan GH-S: GH144 and GH162 <cite>Tanaka2019, Abe2017, Tanaka2024</cite>
+* Related families of a new clan GH-S: [[GH144]] and [[GH162]] <cite>Tanaka2019, Abe2017, Tanaka2024</cite>
 ----

@@ Line 3: / Line 3: @@
 Nobukiyo Tanaka received a Ph.Dr. in Science from Tokyo University of Science under the supervision of Dr. Hayao Taguchi and Dr. Masahiro Nakajima in 2019. He is currently an assistant professor at the same university.
-=== '''Creation of a new GH162 and GH189 family''' ===
+=== '''Creation of a new GH162 and GH189 family (Family first)''' ===
 He has identified and characterized ''Talaromyces funiculosus'' ''endo''-β-1,2-glucanase (TfSGL) and determined its 3D structures. TfSGL does not share any homology with known glycoside hydrolases (GHs). He demonstrated that the reaction mechanism of TfSGL shows clear differences in the reaction pathways from those of GH enzymes. This leads to the classification of the TfSGL group as a new GH family 162 <cite>Tanaka2019</cite>.
@@ Line 9: / Line 9: @@
 Furthermore, in 2024, he performed functional and structural analyses of the cyclization domain of CGS alone from ''Thermoanaerobacter italicus'' (TiCGS<sub>Cy</sub>), identified catalytic residues, and determined its 3D structures. This study showed that TiCGS<sub>Cy</sub> exhibits low sequence homology with known GH enzymes and possesses a unique catalytic reaction mechanism. Consequently, the CGSs group is defined as a new GH family 189 <cite>Tanaka2024</cite>.
-=== '''Establishment of a new clan GH-S''' ===
+=== '''Establishment of a new clan GH-S (Clan first)''' ===
 He revealed that the overall structure of TfSGL, which has a (α/α)<sub>6</sub> fold, is similar to that of a prokaryotic ''endo''-β-1,2-glucanase (CpSGL, belonging to GH144), and one of the catalytic residues overlaps significantly. This finding suggested that TfSGL (GH162) and CpSGL (GH144) constitute a new clan, GH-S <cite>Tanaka2019, Abe2017, Tanaka2024</cite>.

@@ Line 3: / Line 3: @@
 Nobukiyo Tanaka received a Ph.Dr. in Science from Tokyo University of Science under the supervision of Dr. Hayao Taguchi and Dr. Masahiro Nakajima in 2019. He is currently an assistant professor at the same university.
-=== Creation of a new GH162 and GH189 family ===
+=== '''Creation of a new GH162 and GH189 family''' ===
 He has identified and characterized ''Talaromyces funiculosus'' ''endo''-β-1,2-glucanase (TfSGL) and determined its 3D structures. TfSGL does not share any homology with known glycoside hydrolases (GHs). He demonstrated that the reaction mechanism of TfSGL shows clear differences in the reaction pathways from those of GH enzymes. This leads to the classification of the TfSGL group as a new GH family 162 <cite>Tanaka2019</cite>.
@@ Line 13: / Line 13: @@
 He revealed that the overall structure of TfSGL, which has a (α/α)<sub>6</sub> fold, is similar to that of a prokaryotic ''endo''-β-1,2-glucanase (CpSGL, belonging to GH144), and one of the catalytic residues overlaps significantly. This finding suggested that TfSGL (GH162) and CpSGL (GH144) constitute a new clan, GH-S <cite>Tanaka2019, Abe2017, Tanaka2024</cite>.
-=== '''Family and clan first''' ===
 * [[GH162]]: ''endo''-&beta;-1,2-glucanase from ''Talaromyces funiculosus'' <cite>Tanaka2019</cite>
 * [[GH189]]: The cyclization domain alone of cyclic β-1,2-glucan synthase from ''Thermoanaerobacter italicus'' <cite>Tanaka2024</cite>
-* Clan GH-S of related families: GH144 and GH162 <cite>Tanaka2019, Abe2017, Tanaka2024</cite>
+* Related families of a new clan GH-S: GH144 and GH162 <cite>Tanaka2019, Abe2017, Tanaka2024</cite>
 ----

@@ Line 16: / Line 16: @@
 * [[GH162]]: ''endo''-&beta;-1,2-glucanase from ''Talaromyces funiculosus'' <cite>Tanaka2019</cite>
 * [[GH189]]: The cyclization domain alone of cyclic β-1,2-glucan synthase from ''Thermoanaerobacter italicus'' <cite>Tanaka2024</cite>
-* Clan GH-S of related families: GH144 and GH162 <cite>Tanaka2024</cite>
+* Clan GH-S of related families: GH144 and GH162 <cite>Tanaka2019, Abe2017, Tanaka2024</cite>
 ----

@@ Line 16: / Line 16: @@
 * [[GH162]] ''endo''-&beta;-1,2-glucanase from ''Talaromyces funiculosus'' <cite>Tanaka2019</cite>
 * [[GH189]] The cyclization domain alone of cyclic β-1,2-glucan synthase from ''Thermoanaerobacter italicus'' <cite>Tanaka2024</cite>
-* GH clans of related families  GH144 and GH162 <cite>Tanaka2024</cite>
+* Clan GH-S of related families  GH144 and GH162 <cite>Tanaka2024</cite>
 ----