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Carbohydrate Esterase Family 2
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|Carbohydrate Esterase Family CE2|
|Active site residues|
|CAZy DB link|
All of the well characterized carbohydrate esterase family 2 enzymes have been shown to remove acetate groups from the synthetic molecule, 4-nitrophenyl acetate (4p-NP-AcC) (Montanier et al. 2009; Till et al. 2013). Contrary to typical acetyl xylan esterases, CE2 family members are shown to have a strong preference for the deacetylation of xylopyranosides at positions 3 and 4 instead of the typical deacetylation at position 2. CE2 family members were also shown to have significant preference for deacetylation of glucopyranosyl and mannopyranosyl residues at the 6-O position and significantly preferred deacetylation of glucopyranosyl and mannopyranosyl residues relative to the deacetylation of xylopyranosides. For these reasons CE2 family members are considered to be 6-de-O-acetylases (Topakas et al. 2010).
Kinetics and Mechanism
- First characterized
- First mechanistic insight
- First 3-D structure