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General acid/base
- Author: Spencer Williams
- Responsible Curator: Spencer Williams
Overview
The term general acid/base (also catalytic acid/base) refers to an amino acid residue in a glycoside hydrolase or a related enzyme that participates in the mechanism of hydrolysis by removing or adding a proton. The mechanism may be a retaining or inverting mechanism. General acid/base catalysis differs from specific acid/base catalysis as in the latter it is the solvent that acts as the acid or base.
