CAZypedia needs your help! We have many unassigned GH, PL, CE, AA, GT, and CBM pages in need of Authors and Responsible Curators.
Scientists at all career stages, including students, are welcome to contribute to CAZypedia. Read more here, and in the 10th anniversary article in Glycobiology.
New to the CAZy classification? Read this first.
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Consider attending the 15th Carbohydrate Bioengineering Meeting in Ghent, 5-8 May 2024.
Glycoside Hydrolase Family 145
- Responsible Curator: ^^^Bernard Henrissat^^^
This page has been approved by the Responsible Curator as essentially complete. CAZypedia is a living document, so further improvement of this page is still possible. If you would like to suggest an addition or correction, please contact the page's Responsible Curator directly by e-mail.
This family has been deleted from the CAZy classification. A specific explanation may be found below.
GH145 is a deleted family
This family has been reclassified as Polysaccharide Lyase Family 42. Members of the family were originally shown to have hydrolase activity catalyzed by an active site on the posterior side of the beta-propeller structure [1]. Subsequently, lyase activity on alpha-L-Rha-1,4-alpha-D-GlcA via a well-conserved active site on the anterior surface, with strong similarity to PL24 and PL25 was demonstrated in bacterial and fungal homologs.
References
- Munoz-Munoz J, Cartmell A, Terrapon N, Henrissat B, and Gilbert HJ. (2017). Unusual active site location and catalytic apparatus in a glycoside hydrolase family. Proc Natl Acad Sci U S A. 2017;114(19):4936-4941. DOI:10.1073/pnas.1701130114 |
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| CAZy DB links | |
| http://www.cazy.org/GH145.html | |
| http://www.cazy.org/PL42.html |