25 November 2021 Something to CRO about!:
In our latest Curator Approved
page in a while, Maria Cleveland
has written an extensive history of the Copper Radical Oxidases (CROs) that constitute Auxiliary Activity Family 5
. The archetypal AA5
CRO is the Fusarium graminearum
galactose oxidase, which was first isolated in the 1950s, provided the first 3-D structure in the 1990s, and has been the subject of numerous mechanistic studies up through the new millennium. AA5
also contains the glyoxal oxidases, which were discovered in Wisconsin in the late 1980s and form their own subfamily. More recent work by Maria
, Yann Mathieu
, and others has shown that a wider range of substrate specificities exists in this family than previously anticipated, while the catalytic flexibility of wild-type and mutant enzymes has spurred numerous biotech applications. Slide on over to the AA5 page, which includes a deep reference list, to learn more about these interesting enzymes!
23 June 2021 A free CAZypedia webinar: Check out the presentation on CAZypedia by Senior Curator Elizabeth Ficko-Blean, which was part of a webinar on Recent Advances in Carbohydrate-Active Enzymes organized by Stefan Janecek. Stefan also gave a talk on alpha-amylase bioinformatics, and Nicolas Terrapon gave an overview of the CAZy database in a presentation entitled "Carbohydrate-Active EnZymes Annotation in the High-Throughput Era". More information on the webinar can be found here, and you can watch all three lectures for free on YouTube.
31 May 2021 Celebrating CAZy: The B.A. Stone Award for Excellence in Plant Polysaccharide Biochemistry was awarded to CAZy founder Bernard Henrissat today. CAZy, CAZypedia, and Prof. Bruce Stone have a long, intertwined history, and today we celebrate Bernie's insight to create a sequence-based classification of the Carbohydrate-Active EnZymes, starting with the cellulases.
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