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'''24 October 2019:''' ''A tale of an amoebal CBM:'' The '''[[Carbohydrate Binding Module Family 55]]''' page discussing the pathogenically interesting chitin-binding [[CBM55]] family has been flipped to curator approved. The [[CBM55]] family was first identified from ''Entamoeba histolytica'', a protist that causes dysentery and liver abscessesThe page was authored by '''[[User:John Samuelson|John Samuelson]]''' with  '''[[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]]''' acting as responsible curatorRead more on this amoebal CBM family on the [[CBM55]] page.
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'''3 November 2019:''' ''Xylan-cleaving LPMOs:'' Today, [[Responsible Curator]] '''[[User:Jean-Guy Berrin|Jean-Guy Berrin]]''' approved the '''[[Auxiliary Activity Family 14]]''' page [[Author|authored]] by '''[[User:Marie Couturier|Marie Couturier]]''', which describes one of the newer families of lytic polysaccharide monooxygenases (LPMOs) described in the CAZy database'''[[AA14]]''' was first described in 2018 by '''[[User:Marie Couturier|Marie]]''', '''[[User:Jean-Guy Berrin|Jean-Guy]]''', and their co-workersNotably, they showed that the founding members of this family were specific for the plant cell wall matrix glycan, xylan, which contrasts other families of LPMOs that are predominantly cellulose- or chitin-active.  ''Check out the '''[[AA14]]''' page for more details!''
 
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'''15 October 2019:''' ''A new debut for beta(1-2):'' The '''[[Glycoside Hydrolase Family 144]]''' page, which describes the β-1,2-glucanases in this family, was completed by [[Author]] '''[[User:Koichi Abe|Koichi Abe]]''' and [[Responsible Curator]] '''[[User:Masahiro Nakajima|Masahiro Nakajima]]''' today. '''[[GH144]]''' was founded in 2017 based on a seminal publication by '''[[User:Koichi Abe|Koichi Abe]]''', '''[[User:Masahiro Nakajima|Masahiro Nakajima]]''', and their colleagues.  Interestingly,  '''[[GH144]]''' contains both ''endo''-β-1,2-glucanases ([{{EClink}}3.2.1.71 EC 3.2.1.71]), as well as ''exo''-acting enzymes that release sophorose (Glc-β(1,2)-Glc) from the nonreducing end of β(1,2)-glucan chains ("sophorohydrolases", analogous to the more well-known "cellobiohydrolases") ''Learn more about these enzymes, whose protein structure is distantly related to that of the fungal β-1,2-glucanases from [[GH162]], on the '''[[GH144]]''' page!''
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'''24 October 2019:''' ''A tale of an amoebal CBM:'' The '''[[Carbohydrate Binding Module Family 55]]''' page discussing the pathogenically interesting chitin-binding '''[[CBM55]]''' family has been flipped to curator approved. The '''[[CBM55]]''' family was first identified from ''Entamoeba histolytica'', a protist that causes dysentery and liver abscesses.  The page was authored by '''[[User:John Samuelson|John Samuelson]]''' with '''[[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]]''' acting as responsible curator. ''Read more on this amoebal CBM family on the '''[[CBM55]]''' page.''
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'''1 August 2019:''' ''Sweet Sixteen:'' The '''[[Carbohydrate Binding Module Family 16]]''' page in ''CAZypedia'' has been flipped to [[Curator Approved]] today. The page features '''[[CBM16]]''' members from two environmental bacteria with very different backgrounds:  One bacterium was isolated from a red alga (red seaweed) and its [[GH16]] kappa-carrageenase-appended '''[[CBM16]]''' binds the red algal extracellular matrix polysaccharide carrageenan and influences the processive mechanism of the catalytic module.  The other bacterium was isolated from organic waste leachate and deletion of both its [[CBM16]]s from a [[GH5]] mannanase  severely impairs binding ability of the catalytic module. The '''[[CBM16]]''' page was [[Author]]ed by '''[[User:Maria Matard-Mann|Maria Matard-Mann]]''' with '''[[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]]''' acting as [[Responsible Curator]]. ''Learn more about these "sweet sixteen" CBMs on the '''[[CBM16]]''' page.''
 
  
 
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'''21 July 2019:''' ''Back to the future:'' [[Author]] '''[[User:James Stevenson|James Stevenson]]''' and [[Responsible Curator]] '''[[User:Joel Weadge|Joel Weadge]]''' completed the '''[[Glycoside Hydrolase Family 105]]''' page today, which is related to the recently completed (see below) [[GH88]] page.  Like [[GH88]], '''[[GH105]]''' comprises hexeuronic acid hydrolases that use a distinct mechanism of glycosidic bond cleavage. You can learn more about these enzymes on the '''[[GH105]]''' and [[GH88]] pages.  ''We'd like to especially thank [[User:Joel Weadge|Joel]] and [[User:James Stevenson|James]] for taking the initiative to reach out on their own to offer to produce the [[GH105]] page; this is directly in the spirit of CAZypedia as a [http://dx.doi.org/10.1093/glycob/cwx089  community-led, volunteer resource!]''
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'''15 October 2019:''' ''A new debut for beta(1-2):'' The '''[[Glycoside Hydrolase Family 144]]''' page, which describes the β-1,2-glucanases in this family, was completed by [[Author]] '''[[User:Koichi Abe|Koichi Abe]]''' and [[Responsible Curator]] '''[[User:Masahiro Nakajima|Masahiro Nakajima]]''' today. '''[[GH144]]''' was founded in 2017 based on a seminal publication by '''[[User:Koichi Abe|Koichi Abe]]''', '''[[User:Masahiro Nakajima|Masahiro Nakajima]]''', and their colleagues.  Interestingly,  '''[[GH144]]''' contains both ''endo''-β-1,2-glucanases ([{{EClink}}3.2.1.71 EC 3.2.1.71]), as well as ''exo''-acting enzymes that release sophorose (Glc-β(1,2)-Glc) from the nonreducing end of β(1,2)-glucan chains ("sophorohydrolases", analogous to the more well-known "cellobiohydrolases") ''Learn more about these enzymes, whose protein structure is distantly related to that of the fungal β-1,2-glucanases from [[GH162]], on the '''[[GH144]]''' page!''
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'''17 July 2019:''' ''A flashback on unsaturated glucuronyl hydrolases:'' Back in 2015, [[Author]] '''[[User:Seino Jongkees|Seino Jongkees]]''' essentially completed the '''[[Glycoside Hydrolase Family 88]]''' page, which was finally upgraded to [[Curator Approved]] status today.  '''[[GH88]]''' unsaturated glucuronyl hydrolases use an atypical [[glycoside hydrolase]] mechanism that involves the hydration of the double bond between carbons 4 and 5 of the non-reducing terminal sugar of their substrates and subsequent rearrangement. In this way, the activity of '''[[GH88]]''' enzymes is dependent on the prior action of [[Polysaccharide Lyases]] to produce the required hexenuronic acid terminus. ''Learn more about these non-canonical enzymes, and their cousins in [[GH105]], on the '''[[GH88]]''' page''.
 
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'''15 July 2019:''' ''Of carbohydrates, esters, and lignin:'' [[Author]]s '''[[User:Jenny Arnling Bååth|Jenny Arnling Bååth]]''' and '''[[User:Scott Mazurkewich|Scott Mazurkewich]]''', together with [[Responsible Curator]] '''[[User: Johan Larsbrink| Johan Larsbrink]]''' finalized ''CAZypedia's'' third [[Carbohydrate Esterase Families|Carbohydrate Esterase Family]] page today. '''[[Carbohydrate Esterase Family 15]]''' comprises glucuronoyl esterases that utilize a classical serine hydrolase catalytic triad to cleave pendant non-carbohydrate groups from, for example, plant glucuronoxylan (''i.e.'' [https://doi.org/10.1016/j.sbi.2005.10.008 de-esterification with the sugar as the acid])'''[[CE15]]''' members have therefore be suggested to facilitate the breakdown of lignin-carbohydrate complexes (LCC) and are of growing interest for biomass processing.  ''Learn more about these enzymes, including the seminal work of Peter Biely and colleagues, on the '''[[CE15]]''' page''.
 
 
 
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'''5 June 2019:''' ''New and cool beta(1,2)-glucanases of GH162:'' Today [[Author]] '''[[User:Nobukiyo Tanaka|Nobukiyo Tanaka]]''' and [[Responsible Curator]] '''[[User:Masahiro Nakajima|Masahiro Nakajima]]''' completed the '''[[Glycoside Hydrolase Family 162]]''' page in ''CAZypedia''.  As its high number would imply, '''[[GH162]]''' is one of the newest families in the CAZy classification, of which the first example has been elegantly characterized in 2019 by Drs. '''[[User:Nobukiyo Tanaka|Tanaka]]''' and '''[[User:Masahiro Nakajima|Nakajima]]''' and their colleagues.  '''[[GH162]]''' is a tiny family of mostly fungal members, which has structural and mechanistic commonality with [[GH144]], and may be distantly related to [[GH8]] ([[Clan]] GH-M) and [[GH15]] ([[Clan]] GH-L). ''Learn more about all of these families on their respective pages''.
 
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'''14 May 2019:''' ''Starch... it's not over yet:'' Two new families of starch-binding CBMs, '''[[CBM82]]''' and '''[[CBM83]]''', have joined the CAZypedia ranks. These CBMs are both found in an enormous multi-modular cell-wall anchored enzyme from a gut bacterium. The pages were both authored by '''[[User:Darrell Cockburn|Darrell Cockburn]]''' with '''[[User:Nicole Koropatkin|Nicole Koropatkin]]''' acting as responsible curator. ''Learn more about the new starch-binding '''[[CBM82]]''' and '''[[CBM83]]''' families on their respective pages''.
 
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'''28 February 2019:''' ''CE9 is CE page #2!:''  Graduate student '''[[User:Alex Anderson|Alex Anderson]]''' has completed ''CAZypedia's'' second [[:Category:Carbohydrate Esterase Families|Carbohydrate Esterase (CE)]] family page, '''[[Carbohydrate Esterase Family 9]]''', which was [[Curator Approved]] by his supervisor  '''[[User:Michael Suits|Michael Suits]]''' today.  '''[[CE9]]''' enzymes are metal-dependent ''N''-acetylglucosamine 6-phosphate deacetylases that function in peptidoglycan recycling in bacteria.  '''[[CE9]]''' is a huge family, currently comprising over 10,000 members (nearly all are from bacteria), which underscores their biological importance.  '''[[User:Alex Anderson|Alex]]''' and  '''[[User:Michael Suits|Mike]]''' completed ''CAZypedia's'' first [[:Category:Carbohydrate Esterase Families|CE family page]], [[CE4]] earlier this month, and we thank them for these seminal expansions of of our resource.  ''Learn more about the structure and mechanism of metal-dependent deamidases here: [[CE9]], [[CE4]]''.
 
 
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Latest revision as of 09:52, 4 November 2019

3 November 2019: Xylan-cleaving LPMOs: Today, Responsible Curator Jean-Guy Berrin approved the Auxiliary Activity Family 14 page authored by Marie Couturier, which describes one of the newer families of lytic polysaccharide monooxygenases (LPMOs) described in the CAZy database. AA14 was first described in 2018 by Marie, Jean-Guy, and their co-workers. Notably, they showed that the founding members of this family were specific for the plant cell wall matrix glycan, xylan, which contrasts other families of LPMOs that are predominantly cellulose- or chitin-active. Check out the AA14 page for more details!


24 October 2019: A tale of an amoebal CBM: The Carbohydrate Binding Module Family 55 page discussing the pathogenically interesting chitin-binding CBM55 family has been flipped to curator approved. The CBM55 family was first identified from Entamoeba histolytica, a protist that causes dysentery and liver abscesses. The page was authored by John Samuelson with Elizabeth Ficko-Blean acting as responsible curator. Read more on this amoebal CBM family on the CBM55 page.


15 October 2019: A new debut for beta(1-2): The Glycoside Hydrolase Family 144 page, which describes the β-1,2-glucanases in this family, was completed by Author Koichi Abe and Responsible Curator Masahiro Nakajima today. GH144 was founded in 2017 based on a seminal publication by Koichi Abe, Masahiro Nakajima, and their colleagues. Interestingly, GH144 contains both endo-β-1,2-glucanases (EC 3.2.1.71), as well as exo-acting enzymes that release sophorose (Glc-β(1,2)-Glc) from the nonreducing end of β(1,2)-glucan chains ("sophorohydrolases", analogous to the more well-known "cellobiohydrolases") Learn more about these enzymes, whose protein structure is distantly related to that of the fungal β-1,2-glucanases from GH162, on the GH144 page!