CAZypedia needs your help! We have many unassigned GH, PL, CE, AA, GT, and CBM pages in need of Authors and Responsible Curators.
Scientists at all career stages, including students, are welcome to contribute to CAZypedia. Read more here, and in the 10th anniversary article in Glycobiology.
New to the CAZy classification? Read this first.
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Consider attending the 15th Carbohydrate Bioengineering Meeting in Ghent, 5-8 May 2024.
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13 April 2023 The champagne is on ice: We are ecstatic to report that we’ve hit 50 Curator Approved CAZypedia CBM pages!
The CBM92 and the CBM94 page were finished within under 3 hours of one another. Congratulations to the contributors for both of the pages: new CAZypedia contibutors Xuanwei Mei and Yaoguang Chang for the CBM92 page and longtime CAZypedia contributor Takatsugu Miyazaki for the CBM94 page.
Next stop: 100 CAZypedia CBM pages (this may take a little while).
13 April 2023, 00:20 CBM92 is red hot! CBM92 is one of the newer families of CBMs and it has a red hot preference for the red algal extracellular matrix polysaccharide carrageenan, a complex sulfated galactan. Author Xuanwei Mei describes the novel carrageenan-binding capacities of the biochemically characterized CBM92 which can be found appended to a kappa-carrageenase produced by the marine bacterium Wenyingzhuangia aestuarii. Yaoguang Chang acted as responsible curator on the page. Head on over to the CBM92 page to learn more about this red hot CBM family!
12 April 2023, 21:50 CBM94, one for the books! Three of the CBM94 eukaryotic members have recently been characterized (mouse, silkworm and human) and are described in detail on the CBM94 page which has both been authored and responsibly curated by Takatsugu Miyazaki. These N-acetylglucosamine-specific CBM94s are found on the C-termini of N-acetylglucosaminyltransferase IVa, an enzyme involved in N-glycan biosynthesis. The CBM94 members play important roles in the functionality of their cognate glycosyl transferase catalytic module which is discussed in detail on the CBM94 CAZypedia page. See more on these remarkable eukaryotic CBMs here!
11 January 2023 CBM44, it's what's in store. We begin 2023 right with a Curator Approved CBM44 page. Marie-Katherin Zühlke has authored the page on the characterized bacterial CBM44 shown to interact with polymers containing ß-1,4-linked glucose in their chains. Responsible curator Elizabeth Ficko-Blean is pleased as punch. Check out the CBM44 CAZypedia page to learn more about this CBM family!
25 November 2021 Something to CRO about!: In our latest Curator Approved page in a while, Maria Cleveland has written an extensive history of the Copper Radical Oxidases (CROs) that constitute Auxiliary Activity Family 5. The archetypal AA5 CRO is the Fusarium graminearum galactose oxidase, which was first isolated in the 1950s, provided the first 3-D structure in the 1990s, and has been the subject of numerous mechanistic studies up through the new millennium. AA5 also contains the glyoxal oxidases, which were discovered in Wisconsin in the late 1980s and form their own subfamily. More recent work by Maria, Yann Mathieu, and others has shown that a wider range of substrate specificities exists in this family than previously anticipated, while the catalytic flexibility of wild-type and mutant enzymes has spurred numerous biotech applications. Slide on over to the AA5 page, which includes a deep reference list, to learn more about these interesting enzymes!
23 June 2021 A free CAZypedia webinar: Check out the presentation on CAZypedia by Senior Curator Elizabeth Ficko-Blean, which was part of a webinar on Recent Advances in Carbohydrate-Active Enzymes organized by Stefan Janecek. Stefan also gave a talk on alpha-amylase bioinformatics, and Nicolas Terrapon gave an overview of the CAZy database in a presentation entitled "Carbohydrate-Active EnZymes Annotation in the High-Throughput Era". More information on the webinar can be found here, and you can watch all three lectures for free on YouTube.
31 May 2021 Celebrating CAZy: The B.A. Stone Award for Excellence in Plant Polysaccharide Biochemistry was awarded to CAZy founder Bernard Henrissat today. CAZy, CAZypedia, and Prof. Bruce Stone have a long, intertwined history, and today we celebrate Bernie's insight to create a sequence-based classification of the Carbohydrate-Active EnZymes, starting with the cellulases.