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Difference between revisions of "User:Gustav Vaaje-Kolstad"
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| − | I obtained both my MSc (2001) and PhD (2005) in biochemistry in the group of Vincent Eijsink at the Norwegian University of Life Sciences. | + | I obtained both my MSc (2001) and PhD (2005) in biochemistry in the group of Vincent Eijsink at the Norwegian University of Life Sciences. The main focus of my PhD project was obtaining a deeper insight into catalysis by family GH18 chitinases by combining mutagenesis, enzymology, structural biology and bioinformatic techniques (REFs).During this period I spent a substantial amount of time in the lab of Daan van Aalten at the Wellcome Trust Center in Dundee, Scotland, to learn X-ray crystallography and structural biology in general. After finishing my PhD I obtained a 3 year personal post doc grant of which one year was spent in the lab of Geoff Fincher and Maria Hrmova at the University of Adelaide, Australia, where I studied the role of family GH16 xyloglucan endotransferases (XETs) in plant cell wall remodeling (REFs). |
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| + | In the last year of my PhD period.... | ||
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| + | My main scientific interest lies in understanding the biology of chitin with an emphasis on the molecular mechanisms of chitin degradation | ||
<cite>Vaaje-Kolstad2013</cite> | <cite>Vaaje-Kolstad2013</cite> | ||
Revision as of 00:43, 18 July 2013
I obtained both my MSc (2001) and PhD (2005) in biochemistry in the group of Vincent Eijsink at the Norwegian University of Life Sciences. The main focus of my PhD project was obtaining a deeper insight into catalysis by family GH18 chitinases by combining mutagenesis, enzymology, structural biology and bioinformatic techniques (REFs).During this period I spent a substantial amount of time in the lab of Daan van Aalten at the Wellcome Trust Center in Dundee, Scotland, to learn X-ray crystallography and structural biology in general. After finishing my PhD I obtained a 3 year personal post doc grant of which one year was spent in the lab of Geoff Fincher and Maria Hrmova at the University of Adelaide, Australia, where I studied the role of family GH16 xyloglucan endotransferases (XETs) in plant cell wall remodeling (REFs).
In the last year of my PhD period....
My main scientific interest lies in understanding the biology of chitin with an emphasis on the molecular mechanisms of chitin degradation
[1]
- Vaaje-Kolstad G, Horn SJ, Sørlie M, and Eijsink VG. (2013). The chitinolytic machinery of Serratia marcescens--a model system for enzymatic degradation of recalcitrant polysaccharides. FEBS J. 2013;280(13):3028-49. DOI:10.1111/febs.12181 |
- Aachmann FL, Sørlie M, Skjåk-Bræk G, Eijsink VG, and Vaaje-Kolstad G. (2012). NMR structure of a lytic polysaccharide monooxygenase provides insight into copper binding, protein dynamics, and substrate interactions. Proc Natl Acad Sci U S A. 2012;109(46):18779-84. DOI:10.1073/pnas.1208822109 |
- Payne CM, Baban J, Horn SJ, Backe PH, Arvai AS, Dalhus B, Bjørås M, Eijsink VG, Sørlie M, Beckham GT, and Vaaje-Kolstad G. (2012). Hallmarks of processivity in glycoside hydrolases from crystallographic and computational studies of the Serratia marcescens chitinases. J Biol Chem. 2012;287(43):36322-30. DOI:10.1074/jbc.M112.402149 |
- Horn SJ, Vaaje-Kolstad G, Westereng B, and Eijsink VG. (2012). Novel enzymes for the degradation of cellulose. Biotechnol Biofuels. 2012;5(1):45. DOI:10.1186/1754-6834-5-45 |
- Wong E, Vaaje-Kolstad G, Ghosh A, Hurtado-Guerrero R, Konarev PV, Ibrahim AF, Svergun DI, Eijsink VG, Chatterjee NS, and van Aalten DM. (2012). The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces. PLoS Pathog. 2012;8(1):e1002373. DOI:10.1371/journal.ppat.1002373 |
- Vaaje-Kolstad G, Bøhle LA, Gåseidnes S, Dalhus B, Bjørås M, Mathiesen G, and Eijsink VG. (2012). Characterization of the chitinolytic machinery of Enterococcus faecalis V583 and high-resolution structure of its oxidative CBM33 enzyme. J Mol Biol. 2012;416(2):239-54. DOI:10.1016/j.jmb.2011.12.033 |
- Forsberg Z, Vaaje-Kolstad G, Westereng B, Bunæs AC, Stenstrøm Y, MacKenzie A, Sørlie M, Horn SJ, and Eijsink VG. (2011). Cleavage of cellulose by a CBM33 protein. Protein Sci. 2011;20(9):1479-83. DOI:10.1002/pro.689 |
- Vaaje-Kolstad G, Westereng B, Horn SJ, Liu Z, Zhai H, Sørlie M, and Eijsink VG. (2010). An oxidative enzyme boosting the enzymatic conversion of recalcitrant polysaccharides. Science. 2010;330(6001):219-22. DOI:10.1126/science.1192231 |
- Vaaje-Kolstad G, Bunaes AC, Mathiesen G, and Eijsink VG. (2009). The chitinolytic system of Lactococcus lactis ssp. lactis comprises a nonprocessive chitinase and a chitin-binding protein that promotes the degradation of alpha- and beta-chitin. FEBS J. 2009;276(8):2402-15. DOI:10.1111/j.1742-4658.2009.06972.x |
- Vaaje-Kolstad G, Horn SJ, van Aalten DM, Synstad B, and Eijsink VG. (2005). The non-catalytic chitin-binding protein CBP21 from Serratia marcescens is essential for chitin degradation. J Biol Chem. 2005;280(31):28492-7. DOI:10.1074/jbc.M504468200 |
- Vaaje-Kolstad G, Houston DR, Riemen AH, Eijsink VG, and van Aalten DM. (2005). Crystal structure and binding properties of the Serratia marcescens chitin-binding protein CBP21. J Biol Chem. 2005;280(12):11313-9. DOI:10.1074/jbc.M407175200 |