New to the CAZy classification? Read this first.
Want to learn more about CAZypedia? Read the CAZypedia 10th anniversary article in Glycobiology.

User:Joel Weadge

From CAZypedia
Revision as of 09:02, 19 July 2019 by Joel Weadge (Talk | contribs)
Jump to: navigation, search
Weadge Headshot.jpg


Joel Weadge is an Associate Professor in the Biology Department at Wilfrid Laurier University Dr. Weadge graduated with his B.Sc. from the University of Guelph and then went on to do his Ph.D. in Molecular and Cell Biology at the same institution under Dr. Anthony Clarke while studying peptidoglycan acetylesterases. Dr. Weadge then undertook a research fellowship appointment with Dr. Monica Palcic in the enzymology research group at Carlsberg Laboratory in Copenhagen, Denmark, where he worked on structure-function relationships of glycosyltransferases, including those responsible for blood group determination. He then joined Dr. Lynne Howell’s lab as a postdoctoral fellow at the Hospital for Sick Children in Toronto with CIHR and NSERC fellowships. While at Sick Kids, he continued to work on glycosyltransferases, carbohydrate esterase and acetyltransferases inherent in the alginate biosynthetic complex. Dr. Weadge’s diverse research experiences in the structure-function characterization of glycolic-enzymes and protein export apparati from a variety of carbohydrate systems (peptidoglycan, alginate, blood group antigens) form the basis for his group’s current research interests on cellulose, an exopolysaccharide found in bacterial biofilms.



  1. Weadge JT, Pfeffer JM, and Clarke AJ. (2005) Identification of a new family of enzymes with potential O-acetylpeptidoglycan esterase activity in both Gram-positive and Gram-negative bacteria. BMC Microbiol. 5, 49. DOI:10.1186/1471-2180-5-49 | PubMed ID:16111493 | HubMed [Weadge2005]
  2. Weadge JT, Pfeffer JM, and Clarke AJ. (2005) Identification of a new family of enzymes with potential O-acetylpeptidoglycan esterase activity in both Gram-positive and Gram-negative bacteria. BMC Microbiol. 5, 49. DOI:10.1186/1471-2180-5-49 | PubMed ID:16111493 | HubMed [Weadge2005]
  3. Weadge JT, Pfeffer JM, and Clarke AJ. (2005) Identification of a new family of enzymes with potential O-acetylpeptidoglycan esterase activity in both Gram-positive and Gram-negative bacteria. BMC Microbiol. 5, 49. DOI:10.1186/1471-2180-5-49 | PubMed ID:16111493 | HubMed [Weadge2005]
  4. Weadge JT, Pfeffer JM, and Clarke AJ. (2005) Identification of a new family of enzymes with potential O-acetylpeptidoglycan esterase activity in both Gram-positive and Gram-negative bacteria. BMC Microbiol. 5, 49. DOI:10.1186/1471-2180-5-49 | PubMed ID:16111493 | HubMed [Weadge2005]
  5. Weadge JT and Clarke AJ. (2006) Identification and characterization of O-acetylpeptidoglycan esterase: a novel enzyme discovered in Neisseria gonorrhoeae. Biochemistry. 45, 839-51. DOI:10.1021/bi051679s | PubMed ID:16411760 | HubMed [Weadge2006]
  6. Pfeffer JM, Strating H, Weadge JT, and Clarke AJ. (2006) Peptidoglycan O acetylation and autolysin profile of Enterococcus faecalis in the viable but nonculturable state. J Bacteriol. 188, 902-8. DOI:10.1128/JB.188.3.902-908.2006 | PubMed ID:16428393 | HubMed [Pfeffer2006]
  7. Weadge JT and Clarke AJ. (2007) Neisseria gonorrheae O-acetylpeptidoglycan esterase, a serine esterase with a Ser-His-Asp catalytic triad. Biochemistry. 46, 4932-41. DOI:10.1021/bi700254m | PubMed ID:17388571 | HubMed [Weadge2007]
  8. Li Y, Thapa P, Hawke D, Kondo Y, Furukawa K, Furukawa K, Hsu FF, Adlercreutz D, Weadge J, Palcic MM, Wang PG, Levery SB, and Zhou D. (2009) Immunologic glycosphingolipidomics and NKT cell development in mouse thymus. J Proteome Res. 8, 2740-51. DOI:10.1021/pr801040h | PubMed ID:19284783 | HubMed [Li2009]
  9. Adlercreutz D, Weadge JT, Petersen BO, Duus JØ, Dovichi NJ, and Palcic MM. (2010) Enzymatic synthesis of Gb3 and iGb3 ceramides. Carbohydr Res. 345, 1384-8. DOI:10.1016/j.carres.2010.02.006 | PubMed ID:20206917 | HubMed [Adlercreutz2010]
All Medline abstracts: PubMed | HubMed