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User:Jonathon Briggs
Jonathon Briggs completed his undergraduate degree in Medical Microbiology and Immunology at Newcastle University before undertaking his PhD studies in the lab of Professor Harry Gilbert. His PhD project focused on utilization of various glycan substrates encountered by the prominent gut microbes Bacteroides thetaiotaomicron and Bacteroides ovatus.
Jonathon contributed to the characterization of the B. ovatus xylan utilization system [1], the B. thetaiotaomicron galactan, arabinan, rhamnogalacturonan I [2] and II utilization systems [3]. In the process of characterizing the arabinan and galactan utilization systems he identified the founding members of Glycoside Hydrolase families GH146 and GH147 [3].
Jonathon has recently joined the lab of Harry Brumer at the University of British Columbia.
- Rogowski A, Briggs JA, Mortimer JC, Tryfona T, Terrapon N, Lowe EC, Baslé A, Morland C, Day AM, Zheng H, Rogers TE, Thompson P, Hawkins AR, Yadav MP, Henrissat B, Martens EC, Dupree P, Gilbert HJ, and Bolam DN. (2015). Glycan complexity dictates microbial resource allocation in the large intestine. Nat Commun. 2015;6:7481. DOI:10.1038/ncomms8481 |
- Ndeh D, Rogowski A, Cartmell A, Luis AS, Baslé A, Gray J, Venditto I, Briggs J, Zhang X, Labourel A, Terrapon N, Buffetto F, Nepogodiev S, Xiao Y, Field RA, Zhu Y, O'Neil MA, Urbanowicz BR, York WS, Davies GJ, Abbott DW, Ralet MC, Martens EC, Henrissat B, and Gilbert HJ. (2017). Complex pectin metabolism by gut bacteria reveals novel catalytic functions. Nature. 2017;544(7648):65-70. DOI:10.1038/nature21725 |
- Luis AS, Briggs J, Zhang X, Farnell B, Ndeh D, Labourel A, Baslé A, Cartmell A, Terrapon N, Stott K, Lowe EC, McLean R, Shearer K, Schückel J, Venditto I, Ralet MC, Henrissat B, Martens EC, Mosimann SC, Abbott DW, and Gilbert HJ. (2018). Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides. Nat Microbiol. 2018;3(2):210-219. DOI:10.1038/s41564-017-0079-1 |
- Jones DR, Uddin MS, Gruninger RJ, Pham TTM, Thomas D, Boraston AB, Briggs J, Pluvinage B, McAllister TA, Forster RJ, Tsang A, Selinger LB, and Abbott DW. (2017). Discovery and characterization of family 39 glycoside hydrolases from rumen anaerobic fungi with polyspecific activity on rare arabinosyl substrates. J Biol Chem. 2017;292(30):12606-12620. DOI:10.1074/jbc.M117.789008 |