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User:Kazune Tamura
Kazune Tamura obtained his B.Sc. in Combined Honours in Biochemistry and Chemistry from the University of British Columbia in 2015. During this time, he completed an undergraduate thesis project in the lab of Dr. Harry Brumer where he stayed to complete his Ph.D. focused around the study of microbial utilization of common beta-glucans via polysaccharide utilization loci [1, 2, 3, 4, 5, 6, 7, 8, 9]. He now applies his expertise in carbohydrate biochemistry and structural biology to the investigation of mechanisms of cell-cell adhesion in bacterial biofilms at the University of Oxford and MRC-LMB.
- Tamura K, Hemsworth GR, Déjean G, Rogers TE, Pudlo NA, Urs K, Jain N, Davies GJ, Martens EC, and Brumer H. (2017). Molecular Mechanism by which Prominent Human Gut Bacteroidetes Utilize Mixed-Linkage Beta-Glucans, Major Health-Promoting Cereal Polysaccharides. Cell Rep. 2017;21(2):417-430. DOI:10.1016/j.celrep.2017.09.049 |
- Grondin JM, Tamura K, Déjean G, Abbott DW, and Brumer H. (2017). Polysaccharide Utilization Loci: Fueling Microbial Communities. J Bacteriol. 2017;199(15). DOI:10.1128/JB.00860-16 |
- Tamura K, Foley MH, Gardill BR, Dejean G, Schnizlein M, Bahr CME, Louise Creagh A, van Petegem F, Koropatkin NM, and Brumer H. (2019). Surface glycan-binding proteins are essential for cereal beta-glucan utilization by the human gut symbiont Bacteroides ovatus. Cell Mol Life Sci. 2019;76(21):4319-4340. DOI:10.1007/s00018-019-03115-3 |
- Déjean G, Tamura K, Cabrera A, Jain N, Pudlo NA, Pereira G, Viborg AH, Van Petegem F, Martens EC, and Brumer H. (2020). Synergy between Cell Surface Glycosidases and Glycan-Binding Proteins Dictates the Utilization of Specific Beta(1,3)-Glucans by Human Gut Bacteroides. mBio. 2020;11(2). DOI:10.1128/mBio.00095-20 |
- Tamura K, Dejean G, Van Petegem F, and Brumer H. (2021). Distinct protein architectures mediate species-specific beta-glucan binding and metabolism in the human gut microbiota. J Biol Chem. 2021;296:100415. DOI:10.1016/j.jbc.2021.100415 |
- Tamura K and Brumer H. (2021). Glycan utilization systems in the human gut microbiota: a gold mine for structural discoveries. Curr Opin Struct Biol. 2021;68:26-40. DOI:10.1016/j.sbi.2020.11.001 |
- Jain N, Tamura K, Déjean G, Van Petegem F, and Brumer H. (2021). Orthogonal Active-Site Labels for Mixed-Linkage endo-β-Glucanases. ACS Chem Biol. 2021;16(10):1968-1984. DOI:10.1021/acschembio.1c00063 |
- Behar H, Tamura K, Wagner ER, Cosgrove DJ, and Brumer H. (2021). Conservation of endo-glucanase 16 (EG16) activity across highly divergent plant lineages. Biochem J. 2021;478(16):3063-3078. DOI:10.1042/BCJ20210341 |
- Golisch B, Lei Z, Tamura K, and Brumer H. (2021). Configured for the Human Gut Microbiota: Molecular Mechanisms of Dietary β-Glucan Utilization. ACS Chem Biol. 2021;16(11):2087-2102. DOI:10.1021/acschembio.1c00563 |