User:Marie-Katherin Zuehlke

All my life I have been interested in environmental issues and thus studied (micro)biology. My PhD thesis was dedicated to the bacterial transformation of bisphenols, which are released from plastics and disrupt the endocrine system (laboratory Frieder Schauer). I focused on the structural elucidation of produced transformation products and their risk assessment. As a Post Doc, I have expanded this by the perspective of bacterial physiology and the proteins involved in degradation processes. Here, I am investigating the bacterial breakdown of algal sugars using proteomics and by detailed functional analysis of specific proteins. I am based at the University of Greifswald, Germany, and Station Biologique de Roscoff, France (teams Thomas Schweder and Mirjam Czjzek).

Please find me on ResearchGate.

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1. Zühlke MK, Ficko-Blean E, Bartosik D, Terrapon N, Jeudy A, Jam M, Wang F, Welsch N, Dürwald A, Martin LT, Larocque R, Jouanneau D, Eisenack T, Thomas F, Trautwein-Schult A, Teeling H, Becher D, Schweder T, and Czjzek M. Unveiling the role of novel carbohydrate-binding modules in laminarin interaction of multimodular proteins from marine Bacteroidota during phytoplankton blooms. Environ Microbiol. 2024 May;26(5):e16624. DOI:10.1111/1462-2920.16624 |
2. Beidler I, Steinke N, Schulze T, Sidhu C, Bartosik D, Zühlke MK, Martin LT, Krull J, Dutschei T, Ferrero-Bordera B, Rielicke J, Kale V, Sura T, Trautwein-Schult A, Kirstein IV, Wiltshire KH, Teeling H, Becher D, Bengtsson MM, Hehemann JH, Bornscheuer UT, Amann RI, and Schweder T. Alpha-glucans from bacterial necromass indicate an intra-population loop within the marine carbon cycle. Nat Commun. 2024 May 14;15(1):4048. DOI:10.1038/s41467-024-48301-5 |
3. Beidler I, Robb CS, Vidal-Melgosa S, Zühlke MK, Bartosik D, Solanki V, Markert S, Becher D, Schweder T, and Hehemann JH. Marine bacteroidetes use a conserved enzymatic cascade to digest diatom β-mannan. ISME J. 2023 Feb;17(2):276-285. DOI:10.1038/s41396-022-01342-4 |
4. Dutschei T, Zühlke MK, Welsch N, Eisenack T, Hilkmann M, Krull J, Stühle C, Brott S, Dürwald A, Reisky L, Hehemann JH, Becher D, Schweder T, and Bornscheuer UT. Metabolic engineering enables Bacillus licheniformis to grow on the marine polysaccharide ulvan. Microb Cell Fact. 2022 Oct 10;21(1):207. DOI:10.1186/s12934-022-01931-0 |
5. Dürwald A, Zühlke MK, Schlüter R, Gebbe R, Bartosik D, Unfried F, Becher D, and Schweder T. Reaching out in anticipation: bacterial membrane extensions represent a permanent investment in polysaccharide sensing and utilization. Environ Microbiol. 2021 Jun;23(6):3149-3163. DOI:10.1111/1462-2920.15537 |
6. Zühlke MK, Schlüter R, Mikolasch A, Henning AK, Giersberg M, Lalk M, Kunze G, Schweder T, Urich T, and Schauer F. Biotransformation of bisphenol A analogues by the biphenyl-degrading bacterium Cupriavidusbasilensis - a structure-biotransformation relationship. Appl Microbiol Biotechnol. 2020 Apr;104(8):3569-3583. DOI:10.1007/s00253-020-10406-4 |
7. Reisky L, Préchoux A, Zühlke MK, Bäumgen M, Robb CS, Gerlach N, Roret T, Stanetty C, Larocque R, Michel G, Song T, Markert S, Unfried F, Mihovilovic MD, Trautwein-Schult A, Becher D, Schweder T, Bornscheuer UT, and Hehemann JH. A marine bacterial enzymatic cascade degrades the algal polysaccharide ulvan. Nat Chem Biol. 2019 Aug;15(8):803-812. DOI:10.1038/s41589-019-0311-9 |
8. Zühlke MK, Schlüter R, Mikolasch A, Zühlke D, Giersberg M, Schindler H, Henning AK, Frenzel H, Hammer E, Lalk M, Bornscheuer UT, Riedel K, Kunze G, and Schauer F. Biotransformation and reduction of estrogenicity of bisphenol A by the biphenyl-degrading Cupriavidus basilensis. Appl Microbiol Biotechnol. 2017 May;101(9):3743-3758. DOI:10.1007/s00253-016-8061-z |
9. Zühlke MK, Schlüter R, Henning AK, Lipka M, Mikolasch A, Schumann P, Giersberg M, Kunze G, Schauer F (2016). A novel mechanism of conjugate formation of bisphenol A and its analogues by Bacillus amyloliquefaciens: Detoxification and reduction of estrogenicity of bisphenols. Int Biodeterior Biodegrad. 2016;109:165-173. DOI: 10.1016/j.ibiod.2016.01.019