New to the CAZy classification? Read this first.
Want to learn more about CAZypedia? Read the CAZypedia 10th anniversary article in Glycobiology.
Stefan Janecek is a research scientist at the Institute of Molecular Biology of the Slovak Academy of Sciences, Bratislava, Slovakia and a teacher at the Department of Biology of the Faculty of Natural Sciences, University of SS. Cyril and Methodius, Trnava, Slovakia.
He is a group leader heading the Laboratory of Protein Evolution.
He is most interested in the enzymes and proteins from the alpha-amylase family - the clan GH-H of glycoside hydrolase families GH13, GH70 and GH77 as well as the families GH57 and GH119, especially in their evolution as well as their structure-function and structure-stability relationships. In addition, he is also very interested in bioinformatics studies of starch-binding domains that currently involve twelve CAZy CBM families: CBM20, CBM21, CBM25, CBM26, CBM34, CBM41, CBM45, CBM48, CBM53, CBM58, CBM68 and CBM69.
Stefan works as a protein bioinfomatician, being engaged especially in the in silico studies. In his close collaboration with experimentalists, they have three amylolytic enzymes used as experimental models: (i) GH13 alpha-amylase from Thermococcus hydrothermalis; (ii) GH57 amylopullulanase from Thermococcus hydrothermalis; and (iii) GH77 amylomaltase from Borrelia burgdorferi. The experimental work is focused on protein design of these enzymes based on bioinformatics analyses.
Stefan is founder and main organiser of the international symposia on the alpha-amylase enzyme family - ALAMYs.
He is also the Managing Editor of the journal Biologia, section Cellular and Molecular Biology.