New to the CAZy classification? Read this first.
Want to learn more about CAZypedia? Read the CAZypedia 10th anniversary article in Glycobiology.
Stefan Janecek is a research scientist at the Institute of Molecular Biology of the Slovak Academy of Sciences, Bratislava, Slovakia and a teacher at the Department of Biology of the Faculty of Natural Sciences, University of SS. Cyril and Methodius, Trnava, Slovakia.
He is a group leader heading the Laboratory of Protein Evolution.
He is most interested in the enzymes and proteins from the alpha-amylase family - the clan GH-H of glycoside hydrolase families GH13, GH70 and GH77 as well as families GH57 with GH119, and eventually also GH126, especially in their evolution as well as their structure-function and structure-stability relationships. In addition, he is also very interested in bioinformatics studies of starch-binding domains that currently involve fifteen CAZy CBM families: CBM20, CBM21, CBM25, CBM26, CBM34, CBM41, CBM45, CBM48, CBM53, CBM58, CBM68, CBM69, CBM74, CBM82 and CBM83.
Stefan works as a protein bioinfomatician, being engaged especially in the in silico studies. In his close collaboration with experimentalists, they have three amylolytic enzymes used as experimental models: (i) GH13 alpha-amylase from Thermococcus hydrothermalis; (ii) GH57 amylopullulanase from Thermococcus hydrothermalis; and (iii) GH77 amylomaltase from Borrelia burgdorferi. The experimental work is focused on protein design of these enzymes based on bioinformatics analyses.
He is also founder and the Editor-in-Chief of the brand new, open access journal Amylase.