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Difference between revisions of "User:Yuval Shoham"

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Yuval Shoham is a Professor of Biotechnology at the Technion-Israel Institute of Technology.  He obtained his B.Sc. and M.Sc. in Biology and Microbiology from Tel Aviv University and his PhD in Biochemical Engineering from M.I.T under the supervision of Arnold Demain.  In 1988 he joined the Technion and his research focuses on:  a) the catalytic mechanisms and structure-function relationships of industrial enzymes especially glycoside hydrolases, and b) gene regulation of the hemicellulolytic and cellulolytic systems in ''Geobacillus stearothermophilus'' and ''Clostridium thermocellum''. He was involved in solving the crystal structures of:
 
Yuval Shoham is a Professor of Biotechnology at the Technion-Israel Institute of Technology.  He obtained his B.Sc. and M.Sc. in Biology and Microbiology from Tel Aviv University and his PhD in Biochemical Engineering from M.I.T under the supervision of Arnold Demain.  In 1988 he joined the Technion and his research focuses on:  a) the catalytic mechanisms and structure-function relationships of industrial enzymes especially glycoside hydrolases, and b) gene regulation of the hemicellulolytic and cellulolytic systems in ''Geobacillus stearothermophilus'' and ''Clostridium thermocellum''. He was involved in solving the crystal structures of:
  
* ''C. thermocellum'' cellulosomal CBD  
+
* ''C. thermocellum'' cellulosomal CBD <cite>Tormo1996</cite>
* ''C. thermocellum'' cohesin domain  
+
* ''C. thermocellum'' cohesin domain <cite>Shimon1997</cite>
* ''G. stearothermophilus'' [[GH51]] α-L-arabinofuranosidase  
+
* ''G. stearothermophilus'' [[GH51]] α-L-arabinofuranosidase <cite>Hövel2003</cite>
* ''G. stearothermophilus'' [[GH67]] α-glucuronidase [4]
+
* ''G. stearothermophilus'' [[GH67]] α-glucuronidase <cite>Golan2004</cite>
* ''G. stearothermophilus'' [[GH10]] β-xylanase [5]
+
* ''G. stearothermophilus'' [[GH10]] β-xylanase <cite>Teplitsky2004</cite>
* ''G. stearothermophilus'' [[GH39]] β-xylosidase [6]
+
* ''G. stearothermophilus'' [[GH39]] β-xylosidase <cite>Czjzek2005</cite>
* ''G. stearothermophilus'' [[GH43]] β-xylosidase [7]
+
* ''G. stearothermophilus'' [[GH43]] β-xylosidase <cite>Brüx2006</cite>
* ''G. stearothermophilus'' [[GH43]] 1,5-α-L-arabinanase [8]
+
* ''G. stearothermophilus'' [[GH43]] 1,5-α-L-arabinanase <cite>Alhassid2009</cite>
 +
 
 +
 
 +
----
 +
<biblio>
 +
#Tormo1996 pmid=8918451
 +
#Shimon1997 pmid=9083107
 +
#Hövel2003 pmid=14517232
 +
#Golan2004 pmid=14573597
 +
#Teplitsky2004 pmid=15103129
 +
#Czjzek2005 pmid=16212978
 +
#Brüx2006 pmid=16631196
 +
#Alhassid2009 pmid=19505290
 +
</biblio>
  
  
 
[[Category:Contributors|Shoham, Yuval]]
 
[[Category:Contributors|Shoham, Yuval]]

Revision as of 13:18, 10 May 2010

Yuval Shoham is a Professor of Biotechnology at the Technion-Israel Institute of Technology. He obtained his B.Sc. and M.Sc. in Biology and Microbiology from Tel Aviv University and his PhD in Biochemical Engineering from M.I.T under the supervision of Arnold Demain. In 1988 he joined the Technion and his research focuses on: a) the catalytic mechanisms and structure-function relationships of industrial enzymes especially glycoside hydrolases, and b) gene regulation of the hemicellulolytic and cellulolytic systems in Geobacillus stearothermophilus and Clostridium thermocellum. He was involved in solving the crystal structures of:

  • C. thermocellum cellulosomal CBD [1]
  • C. thermocellum cohesin domain [2]
  • G. stearothermophilus GH51 α-L-arabinofuranosidase [3, 4]
  • G. stearothermophilus GH67 α-glucuronidase [5]
  • G. stearothermophilus GH10 β-xylanase [6]
  • G. stearothermophilus GH39 β-xylosidase [7]
  • G. stearothermophilus GH43 β-xylosidase [8, 9]
  • G. stearothermophilus GH43 1,5-α-L-arabinanase [10]



  1. Tormo J, Lamed R, Chirino AJ, Morag E, Bayer EA, Shoham Y, and Steitz TA. (1996). Crystal structure of a bacterial family-III cellulose-binding domain: a general mechanism for attachment to cellulose. EMBO J. 1996;15(21):5739-51. | Google Books | Open Library PubMed ID:8918451 [Tormo1996]
  2. Shimon LJ, Bayer EA, Morag E, Lamed R, Yaron S, Shoham Y, and Frolow F. (1997). A cohesin domain from Clostridium thermocellum: the crystal structure provides new insights into cellulosome assembly. Structure. 1997;5(3):381-90. DOI:10.1016/s0969-2126(97)00195-0 | PubMed ID:9083107 [Shimon1997]
  3. övel2003 pmid=14517232

    [H]
  4. Golan G, Shallom D, Teplitsky A, Zaide G, Shulami S, Baasov T, Stojanoff V, Thompson A, Shoham Y, and Shoham G. (2004). Crystal structures of Geobacillus stearothermophilus alpha-glucuronidase complexed with its substrate and products: mechanistic implications. J Biol Chem. 2004;279(4):3014-24. DOI:10.1074/jbc.M310098200 | PubMed ID:14573597 [Golan2004]
  5. Teplitsky A, Mechaly A, Stojanoff V, Sainz G, Golan G, Feinberg H, Gilboa R, Reiland V, Zolotnitsky G, Shallom D, Thompson A, Shoham Y, and Shoham G. (2004). Structure determination of the extracellular xylanase from Geobacillus stearothermophilus by selenomethionyl MAD phasing. Acta Crystallogr D Biol Crystallogr. 2004;60(Pt 5):836-48. DOI:10.1107/S0907444904004123 | PubMed ID:15103129 [Teplitsky2004]
  6. Czjzek M, Ben David A, Bravman T, Shoham G, Henrissat B, and Shoham Y. (2005). Enzyme-substrate complex structures of a GH39 beta-xylosidase from Geobacillus stearothermophilus. J Mol Biol. 2005;353(4):838-46. DOI:10.1016/j.jmb.2005.09.003 | PubMed ID:16212978 [Czjzek2005]
  7. üx2006 pmid=16631196

    [Br]
  8. Alhassid A, Ben-David A, Tabachnikov O, Libster D, Naveh E, Zolotnitsky G, Shoham Y, and Shoham G. (2009). Crystal structure of an inverting GH 43 1,5-alpha-L-arabinanase from Geobacillus stearothermophilus complexed with its substrate. Biochem J. 2009;422(1):73-82. DOI:10.1042/BJ20090180 | PubMed ID:19505290 [Alhassid2009]

All Medline abstracts: PubMed