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Difference between revisions of "User talk:Warren Wakarchuk"
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| + | == Comment on tertiary structural relatedness of GH101 and GH13 == | ||
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Dear Warren, | Dear Warren, | ||
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* You have written, that '[[Glycoside Hydrolase Family 101|the recently solved 3D structure of SpGH101 reveals that this protein surprisingly shares some structural features with GH13 alpha-amylases]]', but it is not so surprising. According to PSI-BLAST searches, GH101 is related to [[GH13]], [[GH31]] and many other (β/α)<sub>8</sub>-barrel glycoside hydrolases [1, 2]. | * You have written, that '[[Glycoside Hydrolase Family 101|the recently solved 3D structure of SpGH101 reveals that this protein surprisingly shares some structural features with GH13 alpha-amylases]]', but it is not so surprising. According to PSI-BLAST searches, GH101 is related to [[GH13]], [[GH31]] and many other (β/α)<sub>8</sub>-barrel glycoside hydrolases [1, 2]. | ||
* According to BLAST searches, the seventh domain of SpGH101 and BlGH101 belongs to [http://pfam.sanger.ac.uk/family?entry=NPCBM_assoc family NEW3] of the functionally uncharacterized domains [3]. | * According to BLAST searches, the seventh domain of SpGH101 and BlGH101 belongs to [http://pfam.sanger.ac.uk/family?entry=NPCBM_assoc family NEW3] of the functionally uncharacterized domains [3]. | ||
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References: | References: | ||
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1. [http://bioinform.genetika.ru/members/Naumoff/MB2009E.pdf D.G. Naumoff and M. Carreras. 2009. PSI Protein Classifier: a new program automating PSI-BLAST search results. Molecular Biology (Engl Transl). V.43. N.4. P.652-664.] | 1. [http://bioinform.genetika.ru/members/Naumoff/MB2009E.pdf D.G. Naumoff and M. Carreras. 2009. PSI Protein Classifier: a new program automating PSI-BLAST search results. Molecular Biology (Engl Transl). V.43. N.4. P.652-664.] | ||
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3. [http://bioinform.genetika.ru/members/Naumoff/MB2004E.pdf D.G. Naumoff. 2004. Phylogenetic analysis of α-galactosidases of the GH27 family. Molecular Biology (Engl Transl). V.38. N.3. P.388-399.] | 3. [http://bioinform.genetika.ru/members/Naumoff/MB2004E.pdf D.G. Naumoff. 2004. Phylogenetic analysis of α-galactosidases of the GH27 family. Molecular Biology (Engl Transl). V.38. N.3. P.388-399.] | ||
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--[[User:Daniil Naumoff|Daniil Naumoff]] 11:36, 10 December 2009 (UTC) | --[[User:Daniil Naumoff|Daniil Naumoff]] 11:36, 10 December 2009 (UTC) | ||
Revision as of 10:01, 15 December 2009
Dear Warren,
I would like to pay your attention on some data about GH101 family:
- You have written, that 'the recently solved 3D structure of SpGH101 reveals that this protein surprisingly shares some structural features with GH13 alpha-amylases', but it is not so surprising. According to PSI-BLAST searches, GH101 is related to GH13, GH31 and many other (β/α)8-barrel glycoside hydrolases [1, 2].
- According to BLAST searches, the seventh domain of SpGH101 and BlGH101 belongs to family NEW3 of the functionally uncharacterized domains [3].
--Daniil Naumoff 11:36, 10 December 2009 (UTC)