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Difference between revisions of "User:Lynne Howell"
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| − | [[Image: | + | [[Image:Howell_Lynne_new.jpeg|200px|right]] |
'''Lynne Howell''' obtained an undergraduate degree in Biophysics from the [https://www.leeds.ac.uk/ University of Leeds] in 1983 and a Ph.D. in Crystallography from the [https://london.ac.uk/ University of London] under the guidance of Prof. Dame Jane Goodfellow. She spent three years as a postdoctoral fellow with [https://petskolab.bwh.harvard.edu/ Professor Gregory Petsko] at the [https://www.mit.edu/ Massachusetts Institute of Technology] before moving to Paris to study with Dr. Roberto Poljak and Dr. André Menez at the [https://www.pasteur.fr/en Institut Pasteur]. After a year as a staff scientist in Paris, Dr. Howell joined [https://www.sickkids.ca/Research/Molecular-Medicine/index.html The Hospital of Sick Children] in Toronto in late 1991 and was cross appointed to the [https://www.utoronto.ca/ University of Toronto] shortly thereafter. She’s a recipient of a Canada Research Chair in Structural Biology and her research is focused on microbial biofilm formation, specifically understanding at the molecular level the exopolysaccharide biosynthetic systems of various bacteria and fungi (more information can be found on the [https://lab.research.sickkids.ca/howell/ laboratory webpage]). This work has involved collaborations with [[User: Anthony Clarke|Prof. Anthony Clarke]], [https://sites.chem.utoronto.ca/nitz/ Prof. Mark Nitz], [https://www.universiteitleiden.nl/en/staffmembers/jeroen-codee#tab-1 Prof. Jeroen Codée], [http://klassengroup.ca/ Prof. John Klassen], [https://www.mcgill.ca/microimm/donald-sheppard Prof. Don Sheppard] and [[User: Joel Weadge|Prof. Joel Weadge]], among others. | '''Lynne Howell''' obtained an undergraduate degree in Biophysics from the [https://www.leeds.ac.uk/ University of Leeds] in 1983 and a Ph.D. in Crystallography from the [https://london.ac.uk/ University of London] under the guidance of Prof. Dame Jane Goodfellow. She spent three years as a postdoctoral fellow with [https://petskolab.bwh.harvard.edu/ Professor Gregory Petsko] at the [https://www.mit.edu/ Massachusetts Institute of Technology] before moving to Paris to study with Dr. Roberto Poljak and Dr. André Menez at the [https://www.pasteur.fr/en Institut Pasteur]. After a year as a staff scientist in Paris, Dr. Howell joined [https://www.sickkids.ca/Research/Molecular-Medicine/index.html The Hospital of Sick Children] in Toronto in late 1991 and was cross appointed to the [https://www.utoronto.ca/ University of Toronto] shortly thereafter. She’s a recipient of a Canada Research Chair in Structural Biology and her research is focused on microbial biofilm formation, specifically understanding at the molecular level the exopolysaccharide biosynthetic systems of various bacteria and fungi (more information can be found on the [https://lab.research.sickkids.ca/howell/ laboratory webpage]). This work has involved collaborations with [[User: Anthony Clarke|Prof. Anthony Clarke]], [https://sites.chem.utoronto.ca/nitz/ Prof. Mark Nitz], [https://www.universiteitleiden.nl/en/staffmembers/jeroen-codee#tab-1 Prof. Jeroen Codée], [http://klassengroup.ca/ Prof. John Klassen], [https://www.mcgill.ca/microimm/donald-sheppard Prof. Don Sheppard] and [[User: Joel Weadge|Prof. Joel Weadge]], among others. | ||
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*[[Glycoside Hydrolase Family 39|GH39]] ''Pseudomonas aeruginosa'' PslG, PSL polysaccharide hydrolase <cite>Baker2015</cite> | *[[Glycoside Hydrolase Family 39|GH39]] ''Pseudomonas aeruginosa'' PslG, PSL polysaccharide hydrolase <cite>Baker2015</cite> | ||
*[[Glycoside Hydrolase Family 47|GH47]] ''Penicillium citrinum'' α-1,2-mannosidase <cite>Lobsanov2002</cite> | *[[Glycoside Hydrolase Family 47|GH47]] ''Penicillium citrinum'' α-1,2-mannosidase <cite>Lobsanov2002</cite> | ||
| − | *[[Glycoside Hydrolase Family 114|GH114]] ''Aspergillus fumigatus'' | + | *[[Glycoside Hydrolase Family 114|GH114]] ''Aspergillus fumigatus'' Ega3, an α-1,4-galactosaminidase <cite>Bamford2019</cite> |
| − | *[[Glycoside Hydrolase Family 135|GH135]] | + | *[[Glycoside Hydrolase Family 135|GH135]] ''Aspergillus clavatus'' Sph3, an α-1,4-N-acetylgalactosaminidase <cite>Bamford2015</cite> |
| − | *[[Glycoside Hydrolase Family 153|GH153]] | + | *[[Glycoside Hydrolase Family 153|GH153]] ''Bordetella bronchiseptica'' PgaB (C-terminal domain), a poly-β-1,6-D-glucosamine hydrolase <cite>Little2018</cite> |
*[[Glycoside Hydrolase Family 166|GH166]] ''Pseudomonas aeruginosa'' PelA (N-terminal domain), α-1,4-N-acetylgalactosaminidase <cite>LeMauff2019</cite> | *[[Glycoside Hydrolase Family 166|GH166]] ''Pseudomonas aeruginosa'' PelA (N-terminal domain), α-1,4-N-acetylgalactosaminidase <cite>LeMauff2019</cite> | ||
| − | *[[Carbohydrate Esterase Family 4|CE4]] | + | *[[Carbohydrate Esterase Family 4|CE4]] ''Ammonifex degensii'' IcaB, a poly-β-1,6-N-acetyl-D-glucosamine deacetylase <cite>Little2014</cite> |
| − | *[[Carbohydrate Esterase Family 4|CE4]] | + | *[[Carbohydrate Esterase Family 4|CE4]] ''Bordetella bronchiseptica'' PgaB (N-terminal domain), a poly-β-1,6-N-acetyl-D-glucosamine deacetylase <cite>Little2015</cite> |
*[[Carbohydrate Esterase Family 4|CE4]]/[[Glycoside Hydrolase Family 153|GH153]] ''Escherichia coli'' PgaB, a poly-β-1,6-D-glucosamine deacetylase and hydrolase <cite>Little2014b</cite> | *[[Carbohydrate Esterase Family 4|CE4]]/[[Glycoside Hydrolase Family 153|GH153]] ''Escherichia coli'' PgaB, a poly-β-1,6-D-glucosamine deacetylase and hydrolase <cite>Little2014b</cite> | ||
| − | *[[CE18]] | + | *[[CE18]] and [[Carbohydrate Binding Module Family 87|CBM87]] ''Aspergillus fumigatus'' Agd3, an α-1,4-N-acetylgalactosaminidase deacetylase <cite>Bamford2020</cite> |
*PL5 ''Pseudomonas aeruginosa'' AlgL, (no associated paper) | *PL5 ''Pseudomonas aeruginosa'' AlgL, (no associated paper) | ||
*[[Polysaccharide Lyase Family 7|PL7]] ''Klebsiella pneumoniae'' Alginate lyase, (no associated paper) | *[[Polysaccharide Lyase Family 7|PL7]] ''Klebsiella pneumoniae'' Alginate lyase, (no associated paper) | ||
Latest revision as of 07:53, 15 September 2020
Lynne Howell obtained an undergraduate degree in Biophysics from the University of Leeds in 1983 and a Ph.D. in Crystallography from the University of London under the guidance of Prof. Dame Jane Goodfellow. She spent three years as a postdoctoral fellow with Professor Gregory Petsko at the Massachusetts Institute of Technology before moving to Paris to study with Dr. Roberto Poljak and Dr. André Menez at the Institut Pasteur. After a year as a staff scientist in Paris, Dr. Howell joined The Hospital of Sick Children in Toronto in late 1991 and was cross appointed to the University of Toronto shortly thereafter. She’s a recipient of a Canada Research Chair in Structural Biology and her research is focused on microbial biofilm formation, specifically understanding at the molecular level the exopolysaccharide biosynthetic systems of various bacteria and fungi (more information can be found on the laboratory webpage). This work has involved collaborations with Prof. Anthony Clarke, Prof. Mark Nitz, Prof. Jeroen Codée, Prof. John Klassen, Prof. Don Sheppard and Prof. Joel Weadge, among others.
Her lab has determined the crystal structures of multiple carbohydrate active enzymes including (but not limited to):
- GH39 Pseudomonas aeruginosa PslG, PSL polysaccharide hydrolase [1]
- GH47 Penicillium citrinum α-1,2-mannosidase [2]
- GH114 Aspergillus fumigatus Ega3, an α-1,4-galactosaminidase [3]
- GH135 Aspergillus clavatus Sph3, an α-1,4-N-acetylgalactosaminidase [4]
- GH153 Bordetella bronchiseptica PgaB (C-terminal domain), a poly-β-1,6-D-glucosamine hydrolase [5]
- GH166 Pseudomonas aeruginosa PelA (N-terminal domain), α-1,4-N-acetylgalactosaminidase [6]
- CE4 Ammonifex degensii IcaB, a poly-β-1,6-N-acetyl-D-glucosamine deacetylase [7]
- CE4 Bordetella bronchiseptica PgaB (N-terminal domain), a poly-β-1,6-N-acetyl-D-glucosamine deacetylase [8]
- CE4/GH153 Escherichia coli PgaB, a poly-β-1,6-D-glucosamine deacetylase and hydrolase [9]
- CE18 and CBM87 Aspergillus fumigatus Agd3, an α-1,4-N-acetylgalactosaminidase deacetylase [10]
- PL5 Pseudomonas aeruginosa AlgL, (no associated paper)
- PL7 Klebsiella pneumoniae Alginate lyase, (no associated paper)
- GT15 Saccharomyces cerevisiae ⍺-1,2-monnosyltransferase complex Kre2p/Mnt1p [11]
- Pseudomonas syringae AlgG, β-D-mannuronate (alginate) C5-epimerase [12]
- Pseudomonas putida AlgJ, involved in alginate O-acetylation [13]
- Pseudomonas aeruginosa AlgX, alginate O-acetylase [14]
- Pseudomonas protegens PelX, a C-4 epimerase that interconverts UDP-GalNAc and UDP-GlcNAc [15]
- Bacillus cereus PatB1, peptidoglycan O-acetylase [16]
- Streptococcus pneumoniae OatA, peptidoglycan O-acetylase [17]
- Staphylococcus aureus OatA, peptidoglycan O-acetylase [18]
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