14 February 2020: A rose by any other name would smell as sweet.
The human gut bacterium Roseburia intestinalis
provides a curator approved Carbohydrate Binding Module Family 86
page as a special Valentine Day's gift. CBM86
members are structurally located at the N-termini of GH10
xylanase polypeptides. Roseburia intestinalis
certainly enjoys the sugary xylans it encounters in the dietary tract as a carbon source and likely uses the CBM86
modules to enhance xylan capture through improved xylan affinity for the xylanase enzymes. The CBM86
page was written in record time by Maria Louise Leth
with Maher Abou Hachem
acting as responsible curator. Read more on the 'rosy' xylan-binding CBM86
16 December 2019: Closing the year with marine CAZymes: The Glycoside Hydrolase Family 107 page, which describes a family of endo-1,4-fucanases, was finalized today by Author David Teze and Responsible Curator Alisdair Boraston. The characterized enzymes of this family hydrolyze the marine polysaccharides known as fucoidans (sulfated fucans). First identified by the Roscoff group in 2006 (see e.g. Gurvan Michel and Mirjam Czjzek), recent collaborative work by the Withers and Boraston groups has resolved the structure and mechanism of GH107. Of particular note, crystallography of two GH107 members has revealed similarity with GH29 members, which together now form the new Clan GH-R. See the GH107 page for the details from the seminal publications on this family!
Friday the 13th of December 2019: A spooky Christmas gift: The bacterial CBM71 family is a new addition to CAZypedia CBM just in time for Christmas! The CAZypedia CBM page describes the characterization of two lactose- and lacNAc- binding Pneumococcal CBM71 members. The page was authored by Ben Pluvinage with Alisdair Boraston acting as responsible curator. Find out more on the CBM71 family here!
3 November 2019: Xylan-cleaving LPMOs: Today, Responsible Curator Jean-Guy Berrin approved the Auxiliary Activity Family 14 page authored by Marie Couturier, which describes one of the newer families of lytic polysaccharide monooxygenases (LPMOs) described in the CAZy database. AA14 was first described in 2018 by Marie, Jean-Guy, and their co-workers. Notably, they showed that the founding members of this family were specific for the plant cell wall matrix glycan, xylan, which contrasts other families of LPMOs that are predominantly cellulose- or chitin-active. Check out the AA14 page for more details!
24 October 2019: A tale of an amoebal CBM: The Carbohydrate Binding Module Family 55 page discussing the pathogenically interesting chitin-binding CBM55 family has been flipped to curator approved. The CBM55 family was first identified from Entamoeba histolytica, a protist that causes dysentery and liver abscesses. The page was authored by John Samuelson with Elizabeth Ficko-Blean acting as responsible curator. Read more on this amoebal CBM family on the CBM55 page.
15 October 2019: A new debut for beta(1-2): The Glycoside Hydrolase Family 144 page, which describes the β-1,2-glucanases in this family, was completed by Author Koichi Abe and Responsible Curator Masahiro Nakajima today. GH144 was founded in 2017 based on a seminal publication by Koichi Abe, Masahiro Nakajima, and their colleagues. Interestingly, GH144 contains both endo-β-1,2-glucanases (EC 220.127.116.11), as well as exo-acting enzymes that release sophorose (Glc-β(1,2)-Glc) from the nonreducing end of β(1,2)-glucan chains ("sophorohydrolases", analogous to the more well-known "cellobiohydrolases") Learn more about these enzymes, whose protein structure is distantly related to that of the fungal β-1,2-glucanases from GH162, on the GH144 page!
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