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Difference between revisions of "Transglycosylases"
Harry Brumer (talk | contribs) (changed to "transglycosyl..." throughout) |
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== Overview == | == Overview == | ||
− | '''Transglycosylases''' are a class of GH enzymes that can catalyze the transformation of one glycoside to another. That is, these enzymes catalyze the interchange of an aglycon of a glycoside. Mechanistically, transglycosylases utilize the same mechanism as certain [[retaining]] glycoside hydrolases. Some transglycosidases possess substantial [[glycoside hydrolase]] activity, and some glycoside hydrolases possess transglycosylases activity. Indeed, in many cases it is unclear what the major role of an enzyme that possesses both activities may be. Transglycosylases are [[sequence-based classification|classified]] as [[glycoside hydrolases]] into various GH families on the basis of sequence similarity. | + | '''Transglycosylases''' are a class of GH enzymes that can catalyze the transformation of one glycoside to another. That is, these enzymes catalyze the interchange of an aglycon of a glycoside. Mechanistically, transglycosylases utilize the same mechanism as certain [[retaining]] glycoside hydrolases. Thus, reaction of the glycoside hydrolase with a substrate gives a glycosyl-enzyme intermediate that can be intercepted either by water to give the hydrolysis product, or by another acceptor (often another carbohydrate alcohol), to give a new glycoside or oligosaccharide <cite>Crout1998</cite>. Some transglycosidases possess substantial [[glycoside hydrolase]] activity, and some glycoside hydrolases possess transglycosylases activity. Indeed, in many cases it is unclear what the major role of an enzyme that possesses both activities may be. Transglycosylases are [[sequence-based classification|classified]] as [[glycoside hydrolases]] into various GH families on the basis of sequence similarity. |
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== References == | == References == | ||
<biblio> | <biblio> | ||
− | + | #Crout1998 pmid=9667913 | |
+ | |||
</biblio> | </biblio> | ||
[[Category:Definitions and explanations]] | [[Category:Definitions and explanations]] |
Revision as of 19:01, 2 May 2013
This page is currently under construction. This means that the Responsible Curator has deemed that the page's content is not quite up to CAZypedia's standards for full public consumption. All information should be considered to be under revision and may be subject to major changes.
- Author: Spencer Williams
- Responsible Curator: Spencer Williams
Overview
Transglycosylases are a class of GH enzymes that can catalyze the transformation of one glycoside to another. That is, these enzymes catalyze the interchange of an aglycon of a glycoside. Mechanistically, transglycosylases utilize the same mechanism as certain retaining glycoside hydrolases. Thus, reaction of the glycoside hydrolase with a substrate gives a glycosyl-enzyme intermediate that can be intercepted either by water to give the hydrolysis product, or by another acceptor (often another carbohydrate alcohol), to give a new glycoside or oligosaccharide [1]. Some transglycosidases possess substantial glycoside hydrolase activity, and some glycoside hydrolases possess transglycosylases activity. Indeed, in many cases it is unclear what the major role of an enzyme that possesses both activities may be. Transglycosylases are classified as glycoside hydrolases into various GH families on the basis of sequence similarity.