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Glycoside Hydrolase Family 88

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CAZypedia needs your help: This page is currently lacking a Responsible Curator and one or more Authors. If you are an expert on this family and would like to help us improve CAZypedia by getting involved with writing and maintaining this page, please contact the Primary Curator.
  • If you are interested in contributing to CAZypedia, please see the 10th anniversary publication [1] and this page for an overview of the content and mission of our community-driven resource.
  • All present and future authors of CAZypedia are welcomed to include the CAZypedia article [1] in their publication lists, to acknowledge their essential contributions.
  • Until this CAZypedia page is completed, current information on the composition of GH88 is available via the corresponding page of the CAZy database.



  1. CAZypedia Consortium. (2018) Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes. Glycobiology. 28, 3-8. DOI:10.1093/glycob/cwx089 | PubMed ID:29040563 | HubMed [CAZypedia2018]
Glycoside Hydrolase Family GH88
Clan GH-x
Mechanism retaining/inverting
Active site residues known/not known
CAZy DB link
http://www.cazy.org/GH88.html


Substrate specificities

Content is to be added here.

This is an example of how to make references to a journal article [2]. (See the References section below). Multiple references can go in the same place like this [2, 3]. You can even cite books using just the ISBN [4]. References that are not in PubMed can be typed in by hand [5].


Kinetics and Mechanism

Content is to be added here.


Catalytic Residues

Content is to be added here.


Three-dimensional structures

Content is to be added here.


Family Firsts

First stereochemistry determination
Cite some reference here, with a short (1-2 sentence) explanation [2].
First catalytic nucleophile identification
Cite some reference here, with a short (1-2 sentence) explanation [5].
First general acid/base residue identification
Cite some reference here, with a short (1-2 sentence) explanation [3].
First 3-D structure
Cite some reference here, with a short (1-2 sentence) explanation [4].

References

  1. Comfort DA, Bobrov KS, Ivanen DR, Shabalin KA, Harris JM, Kulminskaya AA, Brumer H, and Kelly RM. (2007) Biochemical analysis of Thermotoga maritima GH36 alpha-galactosidase (TmGalA) confirms the mechanistic commonality of clan GH-D glycoside hydrolases. Biochemistry. 46, 3319-30. DOI:10.1021/bi061521n | PubMed ID:17323919 | HubMed [Comfort2007]
  2. He S and Withers SG. (1997) Assignment of sweet almond beta-glucosidase as a family 1 glycosidase and identification of its active site nucleophile. J Biol Chem. 272, 24864-7. DOI:10.1074/jbc.272.40.24864 | PubMed ID:9312086 | HubMed [He1999]
  3. ISBN: 978-0-240-52118-3 | Google Books | Open Library [StickWilliams]
  4. Sinnott, M.L. (1990) Catalytic mechanisms of enzymic glycosyl transfer. Chem. Rev. 90, 1171-1202. DOI: 10.1021/cr00105a006
    [Sinnott1990]
All Medline abstracts: PubMed | HubMed