CAZypedia needs your help! We have many unassigned GH, PL, CE, AA, GT, and CBM pages in need of Authors and Responsible Curators.
Scientists at all career stages, including students, are welcome to contribute to CAZypedia. Read more here, and in the 10th anniversary article in Glycobiology.
New to the CAZy classification? Read this first.
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Consider attending the 15th Carbohydrate Bioengineering Meeting in Ghent, 5-8 May 2024.
Transglycosylases
- Author: Stephen Withers
- Responsible Curator: Spencer Williams
Overview
Transglycosidases are a class of enzymes that can catalyze the transformation of one glycoside to another. That is, these enzymes catalyze the interchange of an aglycon of a glycoside. Mechanistically, transglycosidases utilize the same mechanism as certain retaining glycoside hydrolases. Indeed, some transglycosidases possess substantial glycoside hydrolase activity, and some glycoside hydrolases possess transglycosidase activity. Indeed, in many cases it is unclear what the major role of an enzyme that possesses both activities may be. Consistent with the commonality of mechanism, transglycosidases are classified as glycoside hydrolases on the basis of sequence similarity.