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Transglycosylases
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- Author: Spencer Williams
- Responsible Curator: Spencer Williams
Overview
Transglycosidases are a class of enzymes that can catalyze the transformation of one glycoside to another. That is, these enzymes catalyze the interchange of an aglycon of a glycoside. Mechanistically, transglycosidases utilize the same mechanism as certain retaining glycoside hydrolases. Indeed, some transglycosidases possess substantial glycoside hydrolase activity, and some glycoside hydrolases possess transglycosidase activity. Indeed, in many cases it is unclear what the major role of an enzyme that possesses both activities may be. Consistent with the commonality of mechanism, transglycosidases are classified as glycoside hydrolases on the basis of sequence similarity.