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Glycoside Hydrolase Family 60

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This family has been deleted from the CAZy classification. A specific explanation may be found below.

GH60 is a deleted family

Subsequent to family creation [1], it was shown that the actual activity was not glycosidic bond hydrolysis, as initially suggested.

Detailed sequence analyses show that the sequences in fact belong to metallopeptidase family M42. Evidence for peptidase activity was experimentally demonstrated by Cottrell et al. [2].


  1. Henrissat B (1997). A new cellulase family. Mol Microbiol. 1997;23(4):848-9. DOI:10.1046/j.1365-2958.1997.2661629.x | PubMed ID:9157255 [Henrissat1997]
  2. Cottrell MT, Yu L, and Kirchman DL. (2005). Sequence and expression analyses of Cytophaga-like hydrolases in a Western arctic metagenomic library and the Sargasso Sea. Appl Environ Microbiol. 2005;71(12):8506-13. DOI:10.1128/AEM.71.12.8506-8513.2005 | PubMed ID:16332841 [Cottrell2005]

All Medline abstracts: PubMed

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