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User:Clelton Santos

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Dr Clelton Santos is a Biologist and holds an MS and Ph.D. in Genetics and Molecular Biology. After Postdoc jobs at the University of Cambridge and the National University of Ireland Galway, He becomes a Research Scientist at the Brazilian Biorenewables National Laboratory (LNBR) from the National Center for Research in Energy and Materials (CNPEM) in Campinas, Sao Paulo, Brazil. His research interests combine structural enzymology and protein engineering for protein discovery and biotechnology application purposes.

He has contributed to structural and functional studies of CAZymes from families GH1 [1, 2] GH54 [3] GH173 [4] CBM89 [4].

  1. Santos CA, Zanphorlin LM, Crucello A, Tonoli CCC, Ruller R, Horta MAC, Murakami MT, and de Souza AP. (2016). Crystal structure and biochemical characterization of the recombinant ThBgl, a GH1 β-glucosidase overexpressed in Trichoderma harzianum under biomass degradation conditions. Biotechnol Biofuels. 2016;9:71. DOI:10.1186/s13068-016-0487-0 | PubMed ID:27006690 [Santos2016]
  2. Santos CA, Morais MAB, Terrett OM, Lyczakowski JJ, Zanphorlin LM, Ferreira-Filho JA, Tonoli CCC, Murakami MT, Dupree P, and Souza AP. (2019). An engineered GH1 β-glucosidase displays enhanced glucose tolerance and increased sugar release from lignocellulosic materials. Sci Rep. 2019;9(1):4903. DOI:10.1038/s41598-019-41300-3 | PubMed ID:30894609 [Santos2019]
  3. Motta MLL, Filho JAF, de Melo RR, Zanphorlin LM, Dos Santos CA, and de Souza AP. (2021). A novel fungal metal-dependent α-L-arabinofuranosidase of family 54 glycoside hydrolase shows expanded substrate specificity. Sci Rep. 2021;11(1):10961. DOI:10.1038/s41598-021-90490-2 | PubMed ID:34040092 [Motta2021]
  4. Cabral L, Persinoti GF, Paixão DAA, Martins MP, Morais MAB, Chinaglia M, Domingues MN, Sforca ML, Pirolla RAS, Generoso WC, Santos CA, Maciel LF, Terrapon N, Lombard V, Henrissat B, and Murakami MT. (2022). Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides. Nat Commun. 2022;13(1):629. DOI:10.1038/s41467-022-28310-y | PubMed ID:35110564 [Cabral2022]

All Medline abstracts: PubMed