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User:David Rose

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Biography

David is originally from Buffalo, New York and completed his undergraduate training in Biophysics at the University of Pennsylvania. He spent one of his undergraduate summers as a research assistant with Greg Petsko at Wayne State University (his family having relocated to the Detroit area) and the rest is history. From Penn, David pursued his D. Phil. at Oxford under Sir David Phillips, working on a collaborative project with Raymond Dwek, thus seeding his interest in carbohydrate-protein interactions. In 1981, he began a postdoc with Greg Petsko, then at MIT, working on antibody structures. In 1984, David immigrated permanently to Canada, as a Research Associate at the National Research Council in Ottawa, and began his work on glycoside hydrolases with a protein engineering project on a GH11 xylanase. On establishment of his own laboratory in 1991 at the Ontario Cancer Institute in Toronto, he continued his participation in the Protein Engineering Network of Centres of Excellence (PENCE), where he teamed up with Steve Withers, Lawrence McIntosh, Tony Warren and others in early studies on the GH10 Cex/CfXyn10A xylanase and its catalytic intermediates. In Toronto, David developed an interest in eukaryotic glycoside hydrolases and his group began a long-term structural, mutagenesis and inhibitor analysis of the GH38 Golgi α-mannosidase II, again in collaboration with Steve Withers and subsequently many other carbohydrate chemists, including Mario Pinto. More recently, David's group has been studying human intestinal glycosidases involve in nutritional starch digestion, the GH31 maltase-glucoamylase and sucrase-isomaltase. In January, 2009, David moved to become Chair of the Department of Biology at University of Waterloo.

More information about David's research can be found at his home page.