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User:Maria Louise Leth

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I am a post doc at The Department of Biotechnology and Biomedicine, Technical University of Denmark. I obtained my PhD degree in 2019 under the supervision of Maher Abou Hachem at the Technical University of Denmark. My PhD studies focused on the enzymatic degradation of xylan and mannan by the human gut symbiont Roseburia intestinalis [1, 2]. My research currently focuses on enzyme discovery for degradation and/or detoxification of pharmaceutical contaminants in waste water in collaboration with The Department of Environment, Technical University of Denmark.

I have contributed to the structure determination and biochemical characterization of:

  • CBM86 Roseburia intestinalis L1-82 xylan binding module, RiCBM86, from the modular xylanase RiXyn10A [3] Family First.

  1. Leth ML, Ejby M, Workman C, Ewald DA, Pedersen SS, Sternberg C, Bahl MI, Licht TR, Aachmann FL, Westereng B, and Abou Hachem M. (2018) Differential bacterial capture and transport preferences facilitate co-growth on dietary xylan in the human gut. Nat Microbiol. 3, 570-580. DOI:10.1038/s41564-018-0132-8 | PubMed ID:29610517 | HubMed [Leth2018]
  2. La Rosa SL, Leth ML, Michalak L, Hansen ME, Pudlo NA, Glowacki R, Pereira G, Workman CT, Arntzen MØ, Pope PB, Martens EC, Hachem MA, and Westereng B. (2019) The human gut Firmicute Roseburia intestinalis is a primary degrader of dietary β-mannans. Nat Commun. 10, 905. DOI:10.1038/s41467-019-08812-y | PubMed ID:30796211 | HubMed [LaRosa2019]
  3. Leth ML, Ejby M, Madland E, Kitaoku Y, Slotboom DJ, Guskov A, Aachmann FL, and Abou Hachem M. (2020) Molecular insight into a new low-affinity xylan binding module from the xylanolytic gut symbiont Roseburia intestinalis. FEBS J. 287, 2105-2117. DOI:10.1111/febs.15117 | PubMed ID:31693302 | HubMed [Leth2019]
All Medline abstracts: PubMed | HubMed