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| − | '''31 January 2018:''' ''A flurry of CBM activity in the new year:'' Over the past two weeks, ''CAZypedia'' has enjoyed the promotion of no less than ''nine(!)'' [[Carbohydrate-binding modules|Carbohydrate-binding module (CBM)]] family pages to [[Curator Approved]] status, thanks to the tenacity of [[CBM]] vanguard '''[[User:Harry Gilbert|Harry Gilbert]]''' and the keen editorial oversight of '''[[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]]'''. [[CAZypedia:Assigned_pages#Carbohydrate_Binding_Module_Families|In order of appearance]], '''[[CBM2]]''', '''[[CBM10]]''', '''[[CBM15]]''', '''[[CBM29]]''', '''[[CBM66]]''', '''[[CBM60]]''' (co-authored by '''[[User:Cedric Montanier|Cedric Montanier]]'''), '''[[CBM46]]''', and '''[[CBM35]]''' all have completed pages, as does the deleted family '''[[CBM7]]'''. These pages cover many classic CBM studies and include examples of [[Carbohydrate-binding modules#Types|type A, type B, and type C CBMs]]. ''The CBM legacy runs deep - learn more about each family on [[Carbohydrate Binding Module Families|their respective pages]].'' | + | '''31 October 2025:''' ''A spooktacular addition to the CAZypedia family!'' Come and say 'Boo!' to the frighteningly well written '''[[CBM13]]''' ''CAZypedia'' page. The '''[[CBM13]]''' family is a '''[[Carbohydrate-binding_modules#Blurred Lines: CBMs, Lectins and Outliers|lectin-like CBM family]]'''. Its first characterized members were lectins, including the B chain from the highly toxic [https://en.wikipedia.org/wiki/Ricin ricin] toxin from ''Ricinus communis''. This spine tingling read was authored by '''[[User:Scott Mazurkewich|Scott Mazurkewich]]''' and '''[[User:Lauren McKee|Lauren McKee]]''' who also acted as responsible curator. ''Come and visit the scariest of ''CAZypedia'' CBM pages, '''[[CBM13|here!]]'''... if you dare...'' |
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| − | '''26 November 2017:''' ''CBM #1:'' Today, [[Carbohydrate-binding modules|CBM]] pioneer '''[[User:Markus Linder|Markus Linder]]''' completed the '''[[Carbohydrate Binding Module Family 1]]''' page. [[CBM1]] comprises the canonical fungal cellulose-binding modules (originally known as cellulose-binding ''domains''), which were first found as stable cystine-knot-containing protein fragments released by controlled proteolysis of cellulases. The planar nature of the substrate-binding face, and linear arrangement of key aromatic residues, represent the archetype of [[Carbohydrate-binding modules|CBMs]] that mediate glycosidase targeting to crystalline polysaccharides. Building on the original discovery of the modules now classified into [[CBM1]] in Sweden, '''[[User:Markus Linder|Markus Linder]]''' (then a Ph.D. student) and Tuula Teeri, working together across the Baltic Sea in Finland, were among the first to undertake structure-function studies and protein engineering of [[CBM1]] using modern molecular techniques in the mid- to late-1990s. ''We're pleased to finally have this one in CAZYpedia - learn more about this seminal CBM family [[CBM1|here]].'' | + | '''29 July 2025:''' ''[[CBM91]] is in the news!'' The xylan binding '''[[CBM91]]''' family ''CAZypedia'' page is up and running. Appended to mainly [[GH43]] xylanases this [[CBM91]] family drives interaction with substrate. The [[CBM91]] page was authored by '''[[User:Daichi Ito|Daichi Ito]]''' who also discovered the initial xylan-binding function which resulted in the creation of the [[CBM91]] CAZy family. ''Read up on this industrially interesting '''[[CBM91]]''' family '''[[CBM91|here]]'''.'' |
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| − | '''11 October 2017:''' ''Ten years of CAZypedia!'' We are proud to announce the publication of a [https://academic.oup.com/glycob/article-lookup/doi/10.1093/glycob/cwx089 new article in ''Glycobiology''] in celebration of ''CAZypedia's'' tenth anniversary online. This article was written on behalf of all of present and future '''[[:Category:Contributors|Contributors]]''' by Curators [[User:Harry Brumer|Harry Brumer]] and [[User:Spencer Williams|Spencer Williams]], with input from a number of key individuals involved in the genesis of ''CAZypedia'' (''see the [https://academic.oup.com/glycob/article-lookup/doi/10.1093/glycob/cwx089 Acknowledgements section] for full details''). A [http://hdl.handle.net/2429/63428 post-print version] of the manuscript will be freely available from the UBC Library Open Collections, in addition to the [https://academic.oup.com/glycob/article-lookup/doi/10.1093/glycob/cwx089 final version] on the ''Glycobiology'' website. ''Thanks to the hard work of a multitude of [[:Category:Contributors|Contributors]], ''CAZypedia'' is a successful example of community-driven, expert-based biocuration. We look forward to the continued development of this resource over the next ten years - and beyond!''
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| − | '''10 September 2017:''' ''Sussing-out starch recognition in CBM58.'' We are excited to report that '''[[User:Nicole Koropatkin|Nicole Koropatkin]]''' has completed the '''[[Carbohydrate Binding Module Family 58]]''' page today. [[CBM58]] constitutes a comparatively small family of CBMs found in bacteria in the phylum Bacteroidetes, including key members of the human gut microbiota such as ''Bacteroides thetaiotaomicron''. Within these bacteria, [[CBM58]] modules are found inserted within the [[GH13]] catalytic module of SusG, the essential outer-membrane-bound amylase of the starch utilization system (sus). [[User:Nicole Koropatkin|Nicole’s]] seminal structural biology has defined the family and provided insight into the recognition of amylose helices by [[CBM58]] members in SusG homologs. ''Read more about this fascinating system [[Carbohydrate Binding Module Family 58|here]].''
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31 October 2025: A spooktacular addition to the CAZypedia family! Come and say 'Boo!' to the frighteningly well written CBM13 CAZypedia page. The CBM13 family is a lectin-like CBM family. Its first characterized members were lectins, including the B chain from the highly toxic ricin toxin from Ricinus communis. This spine tingling read was authored by Scott Mazurkewich and Lauren McKee who also acted as responsible curator. Come and visit the scariest of CAZypedia CBM pages, here!... if you dare...
29 July 2025: CBM91 is in the news! The xylan binding CBM91 family CAZypedia page is up and running. Appended to mainly GH43 xylanases this CBM91 family drives interaction with substrate. The CBM91 page was authored by Daichi Ito who also discovered the initial xylan-binding function which resulted in the creation of the CBM91 CAZy family. Read up on this industrially interesting CBM91 family here.