CAZypedia celebrates the life of Senior Curator Emeritus Harry Gilbert, a true giant in the field, who passed away in September 2025.

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Difference between revisions of "Template:News"

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'''July 3, 2018:''' ''Revenge of the Ruminococci.'' Three CBM families containing characterized CBM members from Ruminococcal bacteria are now on-line in CAZypedia; two of these families contain uniquely Ruminococcal CBMs.   '''[[User:Ana Luis|Ana Luis]]''' authored the pages (in one fell swoop) and '''[[User:Harry Gilbert|Harry Gilbert]]''' acted as responsible curator. Descriptions of families '''[[CBM75]]''', '''[[CBM76]]''' and '''[[CBM77]]''' can be found on their respective CAZypedia pages.
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'''31 October 2025:''' ''A spooktacular addition to the CAZypedia family!'' Come and say 'Boo!' to the frighteningly well written '''[[CBM13]]''' ''CAZypedia'' page. The '''[[CBM13]]''' family is a '''[[Carbohydrate-binding_modules#Blurred Lines: CBMs, Lectins and Outliers|lectin-like CBM family]]'''. Its first characterized members were lectins, including the B chain from the highly toxic [https://en.wikipedia.org/wiki/Ricin ricin] toxin from ''Ricinus communis''. This spine tingling read was authored by '''[[User:Scott Mazurkewich|Scott Mazurkewich]]''' and '''[[User:Lauren McKee|Lauren McKee]]''' who also acted as responsible curator. ''Come and visit the scariest of ''CAZypedia'' CBM pages, '''[[CBM13|here!]]'''...  if you dare...''
 
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'''June 4, 2018:'''  ''When two worlds collide.''  The '''[[CBM81]]''' family has an interesting binding mechanism, mixing characteristics of both [[Carbohydrate-binding_modules#Types|type A]] and [[Carbohydrate-binding_modules#Types|type B]] CBMs.  The binding is enthalpically driven to soluble ligands, so by definition this is a [[Carbohydrate-binding_modules#Types|type B]] interaction;  however, the CBM binding face resembles the flat face of [[Carbohydrate-binding_modules#Types|type A]] (crystalline-polysaccharide binding) CBMs.  '''[[User: Marcelo Liberato|Marcelo Liberato]]''' [[author]]ed the [[CBM81]] page and '''[[User: Fabio Squina|Fabio Squina]]''' acted as the [[Responsible Curator]].  Find out more about the unusual family 81 CBMs '''[[CBM81|here]]'''.
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'''29 July 2025:'''  ''[[CBM91]] is in the news!'' The xylan binding '''[[CBM91]]''' family ''CAZypedia'' page is up and running. Appended to mainly [[GH43]] xylanases this [[CBM91]] family drives interaction with substrate. The [[CBM91]] page was authored by '''[[User:Daichi Ito|Daichi Ito]]''' who also discovered the initial xylan-binding function which resulted in the creation of the [[CBM91]] CAZy family. ''Read up on this industrially interesting '''[[CBM91]]''' family '''[[CBM91|here]]'''.''
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'''25 May 2018:''' ''The almost exclusive expansin associated [[CBM63]] family is on-line.'' An interesting function is described as a bacterial [[CBM63]] targets expansin to biomechanical hotspots in the ''Arabidopsis'' cell wall, where cell wall loosening occurs. The page was authored by '''[[User: Will Chase|Will Chase]]''' and '''[[User: Daniel Cosgrove|Daniel Cosgrove]]''' with '''[[User: Daniel Cosgrove|Daniel Cosgrove]]''' acting as responsible curator.  Learn more about this expansin family CBM [[CBM63|here]].
 
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'''4 May 2018:''' ''CAZypedia's first non-LPMO Auxiliary Activity Family page!''  Today [[Responsible Curator]] '''[[User:Roland Ludwig|Roland Ludwig]]''' [[Curator Approved|approved]] '''[[User:Daniel Kracher|Daniel Kracher's]]''' and his expansive '''[[Auxiliary Activity Family 3]]''' page. '''[[AA3]]''' comprises a number of FAD-dependent redox enzymes including cellobiose dehydrogenase, aryl alcohol oxidase/dehydrogenases, glucose oxidases and glucose dehydrogenases, pyranose dehydrogenase, alcohol oxidase, and pyranose oxidase across four subfamilies. '''''[[User:Roland Ludwig|Roland]]''' and '''[[User:Daniel Kracher|Daniel]]''' have done a monumental job in succinctly capturing the diversity of this family, which you can read about [[Auxiliary Activity Family 3|here]].''
 
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'''2 May 2018:''' ''The [[CBM65]] page has been added to the CAZypedia fold.'' This is a small CAZy family with two currently characterized members from an anaerobic cellulolytic ruminal bacterium. The two [[CBM65]] members bind various beta-glucans and play an important role in enhancing enzymatic activity on substrate. The page was authored by '''[[User:Ana Luis|Ana Luis]]''' and '''[[User:Harry Gilbert|Harry Gilbert]]''' acted as responsible curator. ''Learn more about this CBM family [[CBM65|here]].''
 
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'''1 March 2018:''' The shortest month of the year saw four '''[[CBM]]''' families reach '''[[Curator Approved]]''' status, including two early members.  '''[[User:Harry Gilbert|Harry Gilbert]]''' with input from '''[[User:Ed Bayer|Ed Bayer]]''', who also acted as '''[[Responsible Curator]]''', authored the cellulose-binding '''[[CBM3]]''' page.  '''[[User:Harry Gilbert|Harry Gilbert]]''' and '''[[User:Claire Dumon|Claire Dumon]]''' both contributed to the xylan and glucan-binding '''[[CBM4]]''' page.  The xylan-binding '''[[CBM22]]''' page was taken on by '''[[User:Harry Gilbert|Harry Gilbert]]''' solo.  Finally, the cellulose-binding '''[[CBM78]]''' family was authored by '''[[User:Immacolata Venditto|Immacolata Venditto]]''', with '''[[User:Harry Gilbert|Harry Gilbert]]''' acting as '''[[Responsible Curator]]'''.  ''Learn more about each of these families on [[Carbohydrate Binding Module Families|their respective pages]].''
 
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'''15 February 2018:''' ''More on pectin, and also arabinan:''  '''[[User:Jonathon Briggs|Jonathon Briggs]]''' recently completed the '''[[Glycoside Hydrolase Family 147]]''' and '''[[Glycoside Hydrolase Family 146]]''' pages, which are involved in the utilization of pectin and galactan, respectively, by human gut Bacteroidetes.  Both pages were upgraded to [[Curator Approved]] status today by [[Responsible Curator]] '''[[User:Harry Gilbert|Harry Gilbert]]'''.  ''Learn more about these newly described families at [[GH146]] and [[GH147]].''
 
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'''13 February 2018:''' ''The intricacies of pectin deconstruction:'' Rhamnogalacturonan II (RGII) represents the most structurally complex plant cell wall polysaccharide currently known, the complete saccharification of which requires a battery of CAZymes.  Under the guidance of [[Responsible Curator]] '''[[User:Harry Gilbert|Harry Gilbert]]''', four new GH pages related to RGII deconstruction were [[Curator Approved]] today. Special thanks go to [[Author]]s '''[[User:Ana Luis|Ana Luis]]''' ('''[[GH106]]''', '''[[GH139]]''', and '''[[GH141]]''') and '''[[User:Didier Ndeh|Didier Ndeh]]''' ('''[[GH138]]''') for their hard work in putting these pages together. ''Learn more about the individual, specific contributions of each of these families (three of which have been recently uncovered) to microbial RGII utilization on their respective pages.''
 
 
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Latest revision as of 10:50, 3 November 2025

31 October 2025: A spooktacular addition to the CAZypedia family! Come and say 'Boo!' to the frighteningly well written CBM13 CAZypedia page. The CBM13 family is a lectin-like CBM family. Its first characterized members were lectins, including the B chain from the highly toxic ricin toxin from Ricinus communis. This spine tingling read was authored by Scott Mazurkewich and Lauren McKee who also acted as responsible curator. Come and visit the scariest of CAZypedia CBM pages, here!... if you dare...

29 July 2025: CBM91 is in the news! The xylan binding CBM91 family CAZypedia page is up and running. Appended to mainly GH43 xylanases this CBM91 family drives interaction with substrate. The CBM91 page was authored by Daichi Ito who also discovered the initial xylan-binding function which resulted in the creation of the CBM91 CAZy family. Read up on this industrially interesting CBM91 family here.

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