CAZypedia celebrates the life of Senior Curator Emeritus Harry Gilbert, a true giant in the field, who passed away in September 2025.

CAZypedia needs your help!

We have many unassigned pages in need of Authors and Responsible Curators. See a page that's out-of-date and just needs a touch-up? - You are also welcome to become a CAZypedian. Here's how.
Scientists at all career stages, including students, are welcome to contribute.
Learn more about CAZypedia's misson here and in this article. Totally new to the CAZy classification? Read this first.

Difference between revisions of "Template:News"

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'''13 June 2020:''' ''A GH family with lots of unknowns.'' '''[[Glycoside Hydrolase Family 151]]''' is a fairly old family of alpha-L-fucosidases in the CAZy classification, yet a number of key mechanistic and structure-function questions remain to be explored, as we learn in the '''[[GH151]]''' page completed today by '''[[User:Casper Wilkens|Casper Wilkens]]''', '''[[User:David Teze|David Teze]]''', and '''[[User:Birgitte Zeuner|Birgitte Zeuner]]'''. ''See a current example of how information on [[Glycoside Hydrolase Families]] is constantly evolving [[Glycoside Hydrolase Family 151|here]].''
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'''31 October 2025:''' ''A spooktacular addition to the CAZypedia family!'' Come and say 'Boo!' to the frighteningly well written '''[[CBM13]]''' ''CAZypedia'' page.  The '''[[CBM13]]''' family is a '''[[Carbohydrate-binding_modules#Blurred Lines: CBMs, Lectins and Outliers|lectin-like CBM family]]'''. Its first characterized members were lectins, including the B chain from the highly toxic [https://en.wikipedia.org/wiki/Ricin ricin] toxin from ''Ricinus communis''.  This spine tingling read was authored by '''[[User:Scott Mazurkewich|Scott Mazurkewich]]''' and '''[[User:Lauren McKee|Lauren McKee]]''' who also acted as responsible curator. ''Come and visit the scariest of ''CAZypedia'' CBM pages, '''[[CBM13|here!]]'''...  if you dare...''
 
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'''10 June 2020:''' ''A new Senior Curator.'' Today we welcome '''[[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]]''' as a '''[[Board of Curators|Senior Curator]]''' in ''CAZypedia''. Over the past ca. 3 years, [[User:Elizabeth Ficko-Blean|Liz]] has been the major force driving the production of the [[Carbohydrate Binding Module Families|many new Carbohydrate Binding Module Family pages now in ''CAZypedia'']] through the active recruitment of [[Author]]s and [[Responsible Curator]]s, as well as a lot of subsequent editorial work.
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'''29 July 2025:'''  ''[[CBM91]] is in the news!''  The xylan binding '''[[CBM91]]''' family ''CAZypedia'' page is up and running.  Appended to mainly [[GH43]] xylanases this [[CBM91]] family drives interaction with substrate. The [[CBM91]] page was authored by '''[[User:Daichi Ito|Daichi Ito]]''' who also discovered the initial xylan-binding function which resulted in the creation of the [[CBM91]] CAZy family. ''Read up on this industrially interesting '''[[CBM91]]''' family '''[[CBM91|here]]'''.''
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'''10 June 2020:''' ''Back to the origins of CAZy.'' A page on a [[Carbohydrate-binding modules|Carbohydrate Binding Module]] family that was first classified as Cellulose-Binding Domain Family V (CBD V), and has since been renamed in CAZy as '''[[Carbohydrate Binding Module Family 5]]''', is now on-line in ''CAZypedia''. While originally considered to be cellulose-binding domains, there are now several examples of the [[Carbohydrate-binding_modules#Types|type A]] [[CBM5]] members interacting with chitin.  Thank you to '''[[User:Manjeet Kaur|Manjeet Kaur]]'''  for [[author]]ing the page and to '''[[User:Appa Rao Podile|Appa Rao Podile]]''' for acting as [[Responsible Curator]]. ''Read up on this old school family of CBMs '''[[CBM5|here]]'''.''
 
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'''10 June 2020:''' ''Continued growth among the esterases.'' The '''[[Carbohydrate Esterase Family 3]]''' page, [[Author]]ed by grad student '''[[User:Stefen Stangherlin|Stefen Stangherlin]]''', was finalized and [[Curator Approved]] by '''[[User:Joel Weadge|Joel Weadge]]''' and '''[[User:Michael Suits|Michael Suits]]''' today.  '''[[CE3]]''' comprises a group of specific acetyl-xylan esterases with a rich history of initial discovery, mechanistic analysis, and structural characterization. ''We thank '''[[User:Stefen Stangherlin|Stefen]]''', '''[[User:Joel Weadge|Joel]]''', and '''[[User:Michael Suits|Mike]]''' for contributing yet another page to the growing [[Carbohydrate Esterase Families|CE family section]] in CAZypedia - read more on CE3 '''[[Carbohydrate Esterase Family 3|here]]'''.''
 
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'''15 May 2020:''' ''CBM20 for 2020!'' The multifunctional starch-disrupting, starch-binding and enzyme targeting [[CBM20]] family is now up and running in ''CAZypedia''.  These pervasive CBMs have been identified in CAZy families including [[glycoside hydrolases]] and  [[Auxiliary Activity Families|lytic polysaccharide monooxygenases]] but also in non-CAZy enzymes.  The page was authored by '''[[User:Marie Sofie Moeller|Marie Sofie Møller]]''' with '''[[User:Birte Svensson|Birte Svensson]]''' and '''[[User:Stefan Janecek|Stefan Janecek]]''' acting as responsible curators. ''Find out more on this starch-interacting family '''[[CBM20|here]]'''.''
 
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'''15 May 2020:''' ''More on beta(1,3)-glucanases.'' The '''[[Glycoside Hydrolase Family 64]]''' page, [[Author]]ed by '''[[User:Julie Grondin|Julie Grondin]]''',  was completed and [[Curator Approved]] today. '''[[GH64]]''' comprises a group of β-1,3-glucanases, primarily from bacteria.The archetype of this family was originally cloned from a ''Streptomyces'' species in the late 1990's and was the subject of mechanistic and structural analysis through the first decade of the new millenium. Notably, analysis by a team led by '''[[User:Bernard Henrissat|Bernard Henrissat]]''' defined that this enzyme, and thus family, uses an [[inverting]] mechanism, further disntiguishing it from well-known [[retaining]] beta(1,3)-glucanases of [[GH16]], [[GH17]], and others, including the recently described [[GH158]] beta(1,3)-glucanases reported below.  ''Read more about the unique '''[[Glycoside Hydrolase Family 64|Glycoside Hydrolase Family 64 here]]'''.''
 
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'''11 May 2020:''' ''Three more from the gut.'' '''[[User:Alan Cartmell|Alan Cartmell]]''' completed no less than three new [[Glycoside Hydrolase Families|Glycoside Hydrolase Family]] pages on this day.  '''[[Glycoside Hydrolase Family 137]]''', '''[[Glycoside Hydrolase Family 140]]''', and '''[[Glycoside Hydrolase Family 145]]''' were all created from a series of studies of Polysacchardie Utilization Loci from human gut bacteria by '''[[User:Harry Gilbert|Harry Gilbert]]'s''' group, to which '''[[User:Alan Cartmell|Alan]]''' contributed defining crystallography. '''[[User:Alan Cartmell|Alan]]''' has also taken over the duty of [[Responsible Curator]] of these pages following the retirement of the venerable '''[[User:Harry Gilbert|Professor Gilbert]]''', one of ''CAZypedia's'' [[CAZypedia:History|founding Senior Curators]].  ''Read more about the substrate specificity and structural biology of these three diverse families on their corresponding pages.''
 
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'''6 May 2020:''' ''CE #1!'' The first [[Carbohydrate Esterase Families|Carbohydrate Esterase Family]] page in the series, '''[[CE1]]''', was [[Curator Approved]] today.  [[Author]]ed by '''[[User:Casper Wilkens|Casper Wilkens]]''', the '''[[Carbohydrate Esterase Family 1]]''' page describes an old family of carbohydrate-specific and other esterases, members of which were identified through classical biochemistry before the present age of easy gene cloning and sequencing. Carbohydrate-active members of '''[[CE1]]''' include acetyl xylan esterases, cinnamoyl esterases, and feruloyl esterases responsible for hydrolyzing pendant acyl groups from plant cell wall matrix glycans (hemicelluloses). ''Read more about the long history of '''[[Carbohydrate Esterase Family 1]]''' here.''
 
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'''10 April 2020:''' ''Yet another new one from the gut.'' Today, [[Author]] '''[[User:Kazune Tamura|Kazune Tamura]]''' completed the '''[[Glycoside Hydrolase Family 158]]''' page. '''[[GH158]]''' emerged in 2019 from a high-throughput biochemical survey of sequences identified as distantly related to [[glycoside hydrolases]] by the CAZy team, who first demonstrated ''endo''-beta(1,3)-glucanase activity for the founding member of the family from the human gut bacterium ''Victivallis vadensis''. Contemporaneously, analysis of homolgos from human gut ''Bacteroides'' species by Guillaume Dejean and '''[[User:Kazune Tamura|Kazune Tamura]]''' resolved details of the specificity, mechanism, and tertiary structure of '''[[GH158]]''' members in Polysaccharide Utilization Loci. ''Read about the detailed history and juicy details of this new GH family '''[[Glycoside Hydrolase Family 158|here]]'''.''
 
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'''8 April 2020:''' ''Another new one from the gut.'' The '''[[Glycoside Hydrolase Family 164]]''' page, which was [[author]]ed by '''[[User:Zachary Armstrong|Zachary Armstrong]]''', was upgraded to [[Curator Approved]] status by [[Responsible Curator]] '''[[User:Gideon Davies|Gideon Davies]]''' today.  '''[[Glycoside Hydrolase Family 164]]''' is yet another newly discovered [[Glycoside Hydrolase Families|GH family]] from a human gut bacterium - this time through a large-scale effort by teams at AFMB and CERMAV spearheaded by [[User:Bernard Henrissat|Bernard Henrissat]].  The founding member of '''[[GH164]]''' is a beta-mannosidase from ''Bacteroides salyersiae'', on which '''[[User:Zachary Armstrong|Zach]]''' and  '''[[User:Gideon Davies|Gideon]]''' performed a classic mechanistic and structural analysis to define the central aspects of catalysis in this new family. ''Read more about this new - and currently tiny - GH family '''[[Glycoside Hydrolase Family 164|here]]'''.''
 
 
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Latest revision as of 10:50, 3 November 2025

31 October 2025: A spooktacular addition to the CAZypedia family! Come and say 'Boo!' to the frighteningly well written CBM13 CAZypedia page. The CBM13 family is a lectin-like CBM family. Its first characterized members were lectins, including the B chain from the highly toxic ricin toxin from Ricinus communis. This spine tingling read was authored by Scott Mazurkewich and Lauren McKee who also acted as responsible curator. Come and visit the scariest of CAZypedia CBM pages, here!... if you dare...

29 July 2025: CBM91 is in the news! The xylan binding CBM91 family CAZypedia page is up and running. Appended to mainly GH43 xylanases this CBM91 family drives interaction with substrate. The CBM91 page was authored by Daichi Ito who also discovered the initial xylan-binding function which resulted in the creation of the CBM91 CAZy family. Read up on this industrially interesting CBM91 family here.

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