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Difference between revisions of "Glycoside Hydrolase Family 77"
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== Substrate specificities == | == Substrate specificities == | ||
| − | [[Glycoside hydrolase]] family 77 is the member of the α-amylase clan [[GH-H]] <cite>Cantarel2009</cite>, together with [[GH13]] and [[GH70]] <cite>MacGregor2001</cite>. The family contains only one enzyme specificity - the amylomaltase (EC [{{EClink}}2.4.1.25 2.4.1.25]), that is known as disproportionating enzyme (D-enzyme) in plants <cite>Takaha1993</cite> or 4-α-glucanotransferase in bacteria <cite>Terada1999</cite> and archaeons <cite>Kaper2005</cite>. As of April 2010, it has more than 700 members <cite>Cantarel2009</cite> with more than 650 from Bacteria, ~10 from Archaea and a few tens from Eukarya (plants and green algae). | + | [[Glycoside hydrolase]] family 77 is the member of the α-amylase [[clan]] [[GH-H]] <cite>Cantarel2009</cite>, together with [[GH13]] and [[GH70]] <cite>MacGregor2001</cite>. The family contains only one enzyme specificity - the amylomaltase (EC [{{EClink}}2.4.1.25 2.4.1.25]), that is known as disproportionating enzyme (D-enzyme) in plants <cite>Takaha1993</cite> or 4-α-glucanotransferase in bacteria <cite>Terada1999</cite> and archaeons <cite>Kaper2005</cite>. As of April 2010, it has more than 700 members <cite>Cantarel2009</cite> with more than 650 from Bacteria, ~10 from Archaea and a few tens from Eukarya (plants and green algae). |
Amylomaltase catalyses the glucan-chain transfer from one α-1,4-glucan to another α-1,4-glucan (or to 4-hydroxyl group of glucose) or within a single linear glucan molecule to produce a cyclic α-1,4-glucan with degree of polymerization starting from 17 <cite>Takaha1993,Terada1999,Kaper2005</cite>. Cyclodextrin glucanotransferase, a member of the α-amylase family [[GH13]], also produces cyclic α-1,4-glucans, but with a small degree of polymerization (6-8), called cyclodextrins <cite>Leemhuis2010</cite>. | Amylomaltase catalyses the glucan-chain transfer from one α-1,4-glucan to another α-1,4-glucan (or to 4-hydroxyl group of glucose) or within a single linear glucan molecule to produce a cyclic α-1,4-glucan with degree of polymerization starting from 17 <cite>Takaha1993,Terada1999,Kaper2005</cite>. Cyclodextrin glucanotransferase, a member of the α-amylase family [[GH13]], also produces cyclic α-1,4-glucans, but with a small degree of polymerization (6-8), called cyclodextrins <cite>Leemhuis2010</cite>. | ||
Revision as of 00:00, 3 October 2010
This page is currently under construction. This means that the Responsible Curator has deemed that the page's content is not quite up to CAZypedia's standards for full public consumption. All information should be considered to be under revision and may be subject to major changes.
- Author: ^^^Stefan Janecek^^^
- Responsible Curator: ^^^Stefan Janecek^^^
| Glycoside Hydrolase Family GH77 | |
| Clan | GH-H |
| Mechanism | retaining |
| Active site residues | known |
| CAZy DB link | |
| http://www.cazy.org/fam/GH77.html | |
Substrate specificities
Glycoside hydrolase family 77 is the member of the α-amylase clan GH-H [1], together with GH13 and GH70 [2]. The family contains only one enzyme specificity - the amylomaltase (EC 2.4.1.25), that is known as disproportionating enzyme (D-enzyme) in plants [3] or 4-α-glucanotransferase in bacteria [4] and archaeons [5]. As of April 2010, it has more than 700 members [1] with more than 650 from Bacteria, ~10 from Archaea and a few tens from Eukarya (plants and green algae).
Amylomaltase catalyses the glucan-chain transfer from one α-1,4-glucan to another α-1,4-glucan (or to 4-hydroxyl group of glucose) or within a single linear glucan molecule to produce a cyclic α-1,4-glucan with degree of polymerization starting from 17 [3, 4, 5]. Cyclodextrin glucanotransferase, a member of the α-amylase family GH13, also produces cyclic α-1,4-glucans, but with a small degree of polymerization (6-8), called cyclodextrins [6].
Kinetics and Mechanism
Catalytic Residues
Content is to be added here.
Three-dimensional structures
Content is to be added here.
Family Firsts
- First stereochemistry determination
- Cite some reference here, with a short (1-2 sentence) explanation.
- First catalytic nucleophile identification
- Cite some reference here, with a short (1-2 sentence) explanation.
- First general acid/base residue identification
- Cite some reference here, with a short (1-2 sentence) explanation.
- First 3-D structure
- Cite some reference here, with a short (1-2 sentence) explanation.
References
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