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This is the user page of Harry Brumer, Ph.D. I am an Associate Professor in the School of Biotechnology at the Royal Institute of Technology (KTH) in Stockholm Sweden. | This is the user page of Harry Brumer, Ph.D. I am an Associate Professor in the School of Biotechnology at the Royal Institute of Technology (KTH) in Stockholm Sweden. | ||
− | I am also the Vice Chairman of the [[Editorial Board]] and Primary Curator of CAZypedia, which is hosted on servers at KTH Biotechnology. | + | I am also the Vice Chairman of the [[Editorial Board]] and Primary Curator of CAZypedia, which is hosted on servers at KTH Biotechnology. |
+ | |||
+ | If you wish to contact me regarding any issue involving CAZypedia, you can contact me via email: '''harry-at-biotech.kth.se''' (note, copy address and replace "-at-" with "@"). | ||
Details about my current areas of research in fundamental and applied carbohydrate enzymology can be found at my [http://www.biotech.kth.se/woodbiotechnology/brumer_group.html home page]. | Details about my current areas of research in fundamental and applied carbohydrate enzymology can be found at my [http://www.biotech.kth.se/woodbiotechnology/brumer_group.html home page]. |
Revision as of 17:45, 1 August 2007
This is the user page of Harry Brumer, Ph.D. I am an Associate Professor in the School of Biotechnology at the Royal Institute of Technology (KTH) in Stockholm Sweden.
I am also the Vice Chairman of the Editorial Board and Primary Curator of CAZypedia, which is hosted on servers at KTH Biotechnology.
If you wish to contact me regarding any issue involving CAZypedia, you can contact me via email: harry-at-biotech.kth.se (note, copy address and replace "-at-" with "@").
Details about my current areas of research in fundamental and applied carbohydrate enzymology can be found at my home page.
Curriculum vitae
Raised in the northern part of Michigan's lower penninsula, I obtained Bachelor of Science degree in Biochemistry at Michigan State University in East Lansing, MI. Subsequently, I earned a Master of Science degree in Organic Chemistry from the University of Illinois at Chicago, under the supervision of Prof. Robert Moriarty, focussing on the use of carbohydrates as chiral synthons. During my time in Chicago, I met Prof. Michael Sinnott and subsequently relocated to the University of Manchester Institute of Science and Technology (UMIST), where I completed a Ph.D. thesis on the kinetic characterisation of a GH27 alpha-galactosidase from the white-rot fungus Phanerochaete chrysosporium (external examiner Dr. Bernard Henrissat. After a short post-doctoral stint with Prof. Steve Withers in the Department of Chemistry at the University of British Columbia working on glycosidase ligand synthesis and glycosidase active site identification by protein mass spectrometry, I moved to the School of Biotechnology at the Royal Institute of Technology (KTH) to accept a junior faculty position, later earning promotion to Associate Professor (Docent). I am presently a Fellow of the Swedish Research Council (VR Rådsforskare).
Publication list
Below is a list of my publications available on PubMed. It is mainly here for personal use, as a demonstration of Biblio to handle references in CAZypedia. Note that, due to the incompleteness of PubMed, it does not cover my full publication list, which is available in its entirety here.
- Sundqvist G, Stenvall M, Berglund H, Ottosson J, and Brumer H. (2007). A general, robust method for the quality control of intact proteins using LC-ESI-MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;852(1-2):188-94. DOI:10.1016/j.jchromb.2007.01.011 |
- Teeri TT, Brumer H 3rd, Daniel G, and Gatenholm P. (2007). Biomimetic engineering of cellulose-based materials. Trends Biotechnol. 2007;25(7):299-306. DOI:10.1016/j.tibtech.2007.05.002 |
- Nishikubo N, Awano T, Banasiak A, Bourquin V, Ibatullin F, Funada R, Brumer H, Teeri TT, Hayashi T, Sundberg B, and Mellerowicz EJ. (2007). Xyloglucan endo-transglycosylase (XET) functions in gelatinous layers of tension wood fibers in poplar--a glimpse into the mechanism of the balancing act of trees. Plant Cell Physiol. 2007;48(6):843-55. DOI:10.1093/pcp/pcm055 |
- Gloster TM, Ibatullin FM, Macauley K, Eklöf JM, Roberts S, Turkenburg JP, Bjørnvad ME, Jørgensen PL, Danielsen S, Johansen KS, Borchert TV, Wilson KS, Brumer H, and Davies GJ. (2007). Characterization and three-dimensional structures of two distinct bacterial xyloglucanases from families GH5 and GH12. J Biol Chem. 2007;282(26):19177-89. DOI:10.1074/jbc.M700224200 |
- Comfort DA, Bobrov KS, Ivanen DR, Shabalin KA, Harris JM, Kulminskaya AA, Brumer H, and Kelly RM. (2007). Biochemical analysis of Thermotoga maritima GH36 alpha-galactosidase (TmGalA) confirms the mechanistic commonality of clan GH-D glycoside hydrolases. Biochemistry. 2007;46(11):3319-30. DOI:10.1021/bi061521n |
- Gunnarsson LC, Zhou Q, Montanier C, Karlsson EN, Brumer H 3rd, and Ohlin M. (2006). Engineered xyloglucan specificity in a carbohydrate-binding module. Glycobiology. 2006;16(12):1171-80. DOI:10.1093/glycob/cwl038 |
- Neustroev KN, Golubev AM, Sinnott ML, Borriss R, Krah M, Brumer H 3rd, Eneyskaya EV, Shishlyannikov S, Shabalin KA, Peshechonov VT, Korolev VG, and Kulminskaya AA. (2006). Transferase and hydrolytic activities of the laminarinase from Rhodothermus marinus and its M133A, M133C, and M133W mutants. Glycoconj J. 2006;23(7-8):501-11. DOI:10.1007/s10719-006-6733-0 |
- Stiernstedt J, Nordgren N, Wågberg L, Brumer H 3rd, Gray DG, and Rutland MW. (2006). Friction and forces between cellulose model surfaces: a comparison. J Colloid Interface Sci. 2006;303(1):117-23. DOI:10.1016/j.jcis.2006.06.070 |
- Martinez-Fleites C, Guerreiro CI, Baumann MJ, Taylor EJ, Prates JA, Ferreira LM, Fontes CM, Brumer H, and Davies GJ. (2006). Crystal structures of Clostridium thermocellum xyloglucanase, XGH74A, reveal the structural basis for xyloglucan recognition and degradation. J Biol Chem. 2006;281(34):24922-33. DOI:10.1074/jbc.M603583200 |
- Fauré R, Saura-Valls M, Brumer H 3rd, Planas A, Cottaz S, and Driguez H. (2006). Synthesis of a library of xylogluco-oligosaccharides for active-site mapping of xyloglucan endo-transglycosylase. J Org Chem. 2006;71(14):5151-61. DOI:10.1021/jo0525682 |
- Lönnberg H, Zhou Q, Brumer H 3rd, Teeri TT, Malmström E, and Hult A. (2006). Grafting of cellulose fibers with poly(epsilon-caprolactone) and poly(L-lactic acid) via ring-opening polymerization. Biomacromolecules. 2006;7(7):2178-85. DOI:10.1021/bm060178z |
- Stiernstedt J, Brumer H 3rd, Zhou Q, Teeri TT, and Rutland MW. (2006). Friction between cellulose surfaces and effect of xyloglucan adsorption. Biomacromolecules. 2006;7(7):2147-53. DOI:10.1021/bm060100i |
- Saura-Valls M, Fauré R, Ragàs S, Piens K, Brumer H, Teeri TT, Cottaz S, Driguez H, and Planas A. (2006). Kinetic analysis using low-molecular mass xyloglucan oligosaccharides defines the catalytic mechanism of a Populus xyloglucan endotransglycosylase. Biochem J. 2006;395(1):99-106. DOI:10.1042/BJ20051396 |
- Uhlén M, Björling E, Agaton C, Szigyarto CA, Amini B, Andersen E, Andersson AC, Angelidou P, Asplund A, Asplund C, Berglund L, Bergström K, Brumer H, Cerjan D, Ekström M, Elobeid A, Eriksson C, Fagerberg L, Falk R, Fall J, Forsberg M, Björklund MG, Gumbel K, Halimi A, Hallin I, Hamsten C, Hansson M, Hedhammar M, Hercules G, Kampf C, Larsson K, Lindskog M, Lodewyckx W, Lund J, Lundeberg J, Magnusson K, Malm E, Nilsson P, Odling J, Oksvold P, Olsson I, Oster E, Ottosson J, Paavilainen L, Persson A, Rimini R, Rockberg J, Runeson M, Sivertsson A, Sköllermo A, Steen J, Stenvall M, Sterky F, Strömberg S, Sundberg M, Tegel H, Tourle S, Wahlund E, Waldén A, Wan J, Wernérus H, Westberg J, Wester K, Wrethagen U, Xu LL, Hober S, and Pontén F. (2005). A human protein atlas for normal and cancer tissues based on antibody proteomics. Mol Cell Proteomics. 2005;4(12):1920-32. DOI:10.1074/mcp.M500279-MCP200 |
- Kallas AM, Piens K, Denman SE, Henriksson H, Fäldt J, Johansson P, Brumer H, and Teeri TT. (2005). Enzymatic properties of native and deglycosylated hybrid aspen (Populus tremulaxtremuloides) xyloglucan endotransglycosylase 16A expressed in Pichia pastoris. Biochem J. 2005;390(Pt 1):105-13. DOI:10.1042/BJ20041749 |
- Engfeldt T, Renberg B, Brumer H, Nygren PA, and Karlström AE. (2005). Chemical synthesis of triple-labelled three-helix bundle binding proteins for specific fluorescent detection of unlabelled protein. Chembiochem. 2005;6(6):1043-50. DOI:10.1002/cbic.200400388 |
- Ghebremichael KA, Gunaratna KR, Henriksson H, Brumer H, and Dalhammar G. (2005). A simple purification and activity assay of the coagulant protein from Moringa oleifera seed. Water Res. 2005;39(11):2338-44. DOI:10.1016/j.watres.2005.04.012 |
- Greffe L, Bessueille L, Bulone V, and Brumer H. (2005). Synthesis, preliminary characterization, and application of novel surfactants from highly branched xyloglucan oligosaccharides. Glycobiology. 2005;15(4):437-45. DOI:10.1093/glycob/cwi013 |
- Gustavsson MT, Persson PV, Iversen T, Martinelle M, Hult K, Teeri TT, and Brumer H 3rd. (2005). Modification of cellulose fiber surfaces by use of a lipase and a xyloglucan endotransglycosylase. Biomacromolecules. 2005;6(1):196-203. DOI:10.1021/bm049588i |
- Brumer H 3rd, Zhou Q, Baumann MJ, Carlsson K, and Teeri TT. (2004). Activation of crystalline cellulose surfaces through the chemoenzymatic modification of xyloglucan. J Am Chem Soc. 2004;126(18):5715-21. DOI:10.1021/ja0316770 |
- Eriksson T, Stals I, Collén A, Tjerneld F, Claeyssens M, Stålbrand H, and Brumer H. (2004). Heterogeneity of homologously expressed Hypocrea jecorina (Trichoderma reesei) Cel7B catalytic module. Eur J Biochem. 2004;271(7):1266-76. DOI:10.1111/j.1432-1033.2004.04031.x |
- Johansson P, Brumer H 3rd, Baumann MJ, Kallas AM, Henriksson H, Denman SE, Teeri TT, and Jones TA. (2004). Crystal structures of a poplar xyloglucan endotransglycosylase reveal details of transglycosylation acceptor binding. Plant Cell. 2004;16(4):874-86. DOI:10.1105/tpc.020065 |
- Henriksson H, Denman SE, Campuzano ID, Ademark P, Master ER, Teeri TT, and Brumer H 3rd. (2003). N-linked glycosylation of native and recombinant cauliflower xyloglucan endotransglycosylase 16A. Biochem J. 2003;375(Pt 1):61-73. DOI:10.1042/BJ20030485 |
- Borriss R, Krah M, Brumer H 3rd, Kerzhner MA, Ivanen DR, Eneyskaya EV, Elyakova LA, Shishlyannikov SM, Shabalin KA, and Neustroev KN. (2003). Enzymatic synthesis of 4-methylumbelliferyl (1-->3)-beta-D-glucooligosaccharides-new substrates for beta-1,3-1,4-D-glucanase. Carbohydr Res. 2003;338(14):1455-67. DOI:10.1016/s0008-6215(03)00199-x |
- Johansson P, Denman S, Brumer H, Kallas AM, Henriksson H, Bergfors T, Teeri TT, and Jones TA. (2003). Crystallization and preliminary X-ray analysis of a xyloglucan endotransglycosylase from Populus tremula x tremuloides. Acta Crystallogr D Biol Crystallogr. 2003;59(Pt 3):535-7. DOI:10.1107/s090744490202348x |
- Eneyskaya EV, Brumer H 3rd, Backinowsky LV, Ivanen DR, Kulminskaya AA, Shabalin KA, and Neustroev KN. (2003). Enzymatic synthesis of beta-xylanase substrates: transglycosylation reactions of the beta-xylosidase from Aspergillus sp. Carbohydr Res. 2003;338(4):313-25. DOI:10.1016/s0008-6215(02)00467-6 |
- Bourquin V, Nishikubo N, Abe H, Brumer H, Denman S, Eklund M, Christiernin M, Teeri TT, Sundberg B, and Mellerowicz EJ. (2002). Xyloglucan endotransglycosylases have a function during the formation of secondary cell walls of vascular tissues. Plant Cell. 2002;14(12):3073-88. DOI:10.1105/tpc.007773 |
- Brun E, Brumer H 3rd, MacKenzie LF, Withers SG, and McIntosh LP. (2001). Assignment of selectively 13C-labeled cellopentaose synthesized using an engineered glycosynthase. J Biomol NMR. 2001;21(1):67-8. DOI:10.1023/a:1011927400439 |
- Becker D, Braet C, Brumer H 3rd, Claeyssens M, Divne C, Fagerström BR, Harris M, Jones TA, Kleywegt GJ, Koivula A, Mahdi S, Piens K, Sinnott ML, Ståhlberg J, Teeri TT, Underwood M, and Wohlfahrt G. (2001). Engineering of a glycosidase Family 7 cellobiohydrolase to more alkaline pH optimum: the pH behaviour of Trichoderma reesei Cel7A and its E223S/ A224H/L225V/T226A/D262G mutant. Biochem J. 2001;356(Pt 1):19-30. DOI:10.1042/0264-6021:3560019 |
- Hart DO, He S, Chany CJ 2nd, Withers SG, Sims PF, Sinnott ML, and Brumer H 3rd. (2000). Identification of Asp-130 as the catalytic nucleophile in the main alpha-galactosidase from Phanerochaete chrysosporium, a family 27 glycosyl hydrolase. Biochemistry. 2000;39(32):9826-36. DOI:10.1021/bi0008074 |
- Brumer H 3rd, Sims PF, and Sinnott ML. (1999). Lignocellulose degradation by Phanerochaete chrysosporium: purification and characterization of the main alpha-galactosidase. Biochem J. 1999;339 ( Pt 1)(Pt 1):43-53. | Google Books | Open Library