CAZypedia celebrates the life of Senior Curator Emeritus Harry Gilbert, a true giant in the field, who passed away in September 2025.
CAZypedia needs your help!
We have many unassigned pages in need of Authors and Responsible Curators. See a page that's out-of-date and just needs a touch-up? - You are also welcome to become a CAZypedian. Here's how.
Scientists at all career stages, including students, are welcome to contribute.
Learn more about CAZypedia's misson here and in this article. Totally new to the CAZy classification? Read this first.
User:Scott Mazurkewich
Researcher at the Department of Biology and Biological Engineering, Chalmers University of Technology.
Background
Scott obtained both his BSc and PhD from the University of Guelph in Canada. His PhD work, completed under the supervision of Stephen Seah, was on structure-function studies of enzymes involved in the metabolism of aromatic lignin fragments in Pseudomonas [1, 2, 3]. Shortly after completing his PhD studies, he started a post-doctoral research position with Johan Larsbrink at Chalmers University. There he has been working on structure-function studies of CE15 members and other CAZymes.
Selected papers
- Wang W, Mazurkewich S, Kimber MS, and Seah SY. (2010). Structural and kinetic characterization of 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate aldolase, a protocatechuate degradation enzyme evolutionarily convergent with the HpaI and DmpG pyruvate aldolases. J Biol Chem. 2010;285(47):36608-15. DOI:10.1074/jbc.M110.159509 |
- Mazurkewich S, Brott AS, Kimber MS, and Seah SY. (2016). Structural and Kinetic Characterization of the 4-Carboxy-2-hydroxymuconate Hydratase from the Gallate and Protocatechuate 4,5-Cleavage Pathways of Pseudomonas putida KT2440. J Biol Chem. 2016;291(14):7669-86. DOI:10.1074/jbc.M115.682054 |
- Arnling Bååth J, Mazurkewich S, Knudsen RM, Poulsen JN, Olsson L, Lo Leggio L, and Larsbrink J. (2018). Biochemical and structural features of diverse bacterial glucuronoyl esterases facilitating recalcitrant biomass conversion. Biotechnol Biofuels. 2018;11:213. DOI:10.1186/s13068-018-1213-x |
- Mazurkewich S, Poulsen JN, Lo Leggio L, and Larsbrink J. (2019). Structural and biochemical studies of the glucuronoyl esterase OtCE15A illuminate its interaction with lignocellulosic components. J Biol Chem. 2019;294(52):19978-19987. DOI:10.1074/jbc.RA119.011435 |
- Mazurkewich S, Helland R, Mackenzie A, Eijsink VGH, Pope PB, Brändén G, and Larsbrink J. (2020). Structural insights of the enzymes from the chitin utilization locus of Flavobacterium johnsoniae. Sci Rep. 2020;10(1):13775. DOI:10.1038/s41598-020-70749-w |
- Mazurkewich S, Seveso A, Hüttner S, Brändén G, and Larsbrink J. (2021). Structure of a C1/C4-oxidizing AA9 lytic polysaccharide monooxygenase from the thermophilic fungus Malbranchea cinnamomea. Acta Crystallogr D Struct Biol. 2021;77(Pt 8):1019-1026. DOI:10.1107/S2059798321006628 |
- Mazurkewich S, Seveso A, and Larsbrink J. (2023). A unique AA5 alcohol oxidase fused with a catalytically inactive CE3 domain from the bacterium Burkholderia pseudomallei. FEBS Lett. 2023;597(13):1779-1791. DOI:10.1002/1873-3468.14632 |
- Hao MS, Mazurkewich S, Li H, Kvammen A, Saha S, Koskela S, Inman AR, Nakajima M, Tanaka N, Nakai H, Brändén G, Bulone V, Larsbrink J, and McKee LS. (2024). Structural and biochemical analysis of family 92 carbohydrate-binding modules uncovers multivalent binding to β-glucans. Nat Commun. 2024;15(1):3429. DOI:10.1038/s41467-024-47584-y |
- Mazurkewich S, Widén T, Karlsson H, Evenäs L, Ramamohan P, Wohlert J, Brändén G, and Larsbrink J. (2025). Structural and biochemical basis for activity of Aspergillus nidulans α-1,3-glucanases from glycoside hydrolase family 71. Commun Biol. 2025;8(1):1298. DOI:10.1038/s42003-025-08696-3 |