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Difference between revisions of "Glycoside Hydrolase Family 6"
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* [[Author]]: ^^^Gideon Davies^^^ | * [[Author]]: ^^^Gideon Davies^^^ | ||
* [[Responsible Curator]]: ^^^Gideon Davies^^^ | * [[Responsible Curator]]: ^^^Gideon Davies^^^ | ||
Revision as of 08:54, 28 September 2009
This page is currently under construction. This means that the Responsible Curator has deemed that the page's content is not quite up to CAZypedia's standards for full public consumption. All information should be considered to be under revision and may be subject to major changes.
- Author: ^^^Gideon Davies^^^
- Responsible Curator: ^^^Gideon Davies^^^
| Glycoside Hydrolase Family GH6 | |
| Clan | none |
| Mechanism | inverting |
| Active site residues | acid known, base debated |
| CAZy DB link | |
| http://www.cazy.org/fam/GH6.html | |
Substrate specificities
Endoglucanases (EC 3.2.1.4) and cellobiohydrolases (EC 3.2.1.91)only. Both classes of enzyme active on cellulose / beta 1,4 glucans.
Kinetics and Mechanism
Content is to be added here.
Catalytic Residues
Content is to be added here.
Three-dimensional structures
Content is to be added here.
Family Firsts
- First sterochemistry determination
- Cite some reference here, with a short (1-2 senetence) explanation [1].
- First catalytic nucleophile identification
- Cite some reference here, with a short (1-2 senetence) explanation [2].
- First general acid/base residue identification
- Cite some reference here, with a short (1-2 senetence) explanation [3].
- First 3-D structure
- The Trichoderma reesei (the organism now known as Hypocrea jecorina) cellobiohydrolase II by the Jones group [4].
References
-
Sinnott, M.L. (1990) Catalytic mechanisms of enzymic glycosyl transfer. Chem. Rev. 90, 1171-1202. DOI: 10.1021/cr00105a006
- He S and Withers SG. (1997). Assignment of sweet almond beta-glucosidase as a family 1 glycosidase and identification of its active site nucleophile. J Biol Chem. 1997;272(40):24864-7. DOI:10.1074/jbc.272.40.24864 |
- Rouvinen J, Bergfors T, Teeri T, Knowles JK, and Jones TA. (1990). Three-dimensional structure of cellobiohydrolase II from Trichoderma reesei. Science. 1990;249(4967):380-6. DOI:10.1126/science.2377893 |
- Robert V. Stick and Spencer J. Williams. (2009) Carbohydrates. Elsevier Science.
[[Category:Glycoside Hydrolase Families|GHnnn]]