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Glycoside Hydrolase Family 6
- Author: ^^^Gideon Davies^^^
- Responsible Curator: ^^^Gideon Davies^^^
Glycoside Hydrolase Family GH6 | |
Clan | none |
Mechanism | inverting |
Active site residues | acid known, base debated |
CAZy DB link | |
http://www.cazy.org/fam/GH6.html |
Substrate specificities
Endoglucanases (EC 3.2.1.4) and cellobiohydrolases (EC 3.2.1.91)only. Both classes of enzyme active on cellulose / beta 1,4 glucans.
Kinetics and Mechanism
Content is to be added here.
Catalytic Residues
Content is to be added here.
Three-dimensional structures
Content is to be added here.
Family Firsts
- First sterochemistry determination
- Cite some reference here, with a short (1-2 senetence) explanation [1].
- First catalytic nucleophile identification
- Cite some reference here, with a short (1-2 senetence) explanation [2].
- First general acid/base residue identification
- Cite some reference here, with a short (1-2 senetence) explanation [3].
- First 3-D structure
- The Trichoderma reesei (the organism now known as Hypocrea jecorina) cellobiohydrolase II by the Jones group [4].
References
-
Sinnott, M.L. (1990) Catalytic mechanisms of enzymic glycosyl transfer. Chem. Rev. 90, 1171-1202. DOI: 10.1021/cr00105a006
- He S and Withers SG. (1997). Assignment of sweet almond beta-glucosidase as a family 1 glycosidase and identification of its active site nucleophile. J Biol Chem. 1997;272(40):24864-7. DOI:10.1074/jbc.272.40.24864 |
- Rouvinen J, Bergfors T, Teeri T, Knowles JK, and Jones TA. (1990). Three-dimensional structure of cellobiohydrolase II from Trichoderma reesei. Science. 1990;249(4967):380-6. DOI:10.1126/science.2377893 |
- Robert V. Stick and Spencer J. Williams. (2009) Carbohydrates. Elsevier Science.
[[Category:Glycoside Hydrolase Families|GHnnn]]