User:Plinio Vieira

Plinio Vieira obtained his B.Sc. Lic. in Chemistry from the University of São Paulo (2010) and his Ph.D. (2016) at the University of Campinas under the supervision of Mario Murakami. The work focused on the crystallographic studies of NEK kinases from Trypanosomatids, aiming for structural-based drug design. During his post-doc at Brazilian National Center for Research in Energy and Materials under the supervision of Dr. Murakami, he studied Glycoside Hydrolases from Xanthomonas that act on Xyloglucan depolymerization. He also developed a post-doc project under the supervision of Miguel Alcalde at Institute of Catalysis and Petrochemistry, focusing on the random and semi-rational evolution of a GH35 β-galactosidase. He currently works as Researcher Specialist at Brazilian Biorenewables Laboratory, focusing on the discovery and the structure-function-mechanism relationship from CAZymes. He has contributed for the tridimensional structure determination of:

• GH128 Amycolatopsis mediterraneiendo-β-1,3-glucanase E102A mutant, in complex with laminaritriose and laminaribiose PDB ID 6UAU

• GH128 Amycolatopsis mediterraneiendo-β-1,3-glucanase E102A mutant, in complex with laminaripentaose PDB ID 6UAT

• GH128 Amycolatopsis mediterraneiendo-β-1,3-glucanase E102A mutant, in complex with laminarihexaose PDB ID 6UFL

• GH128 Amycolatopsis mediterraneiendo-β-1,3-glucanase E199Q mutant PDB ID 6UBFZ
• GH128 Amycolatopsis mediterraneiendo-β-1,3-glucanase E199A mutant, in complex with laminaripentaose PDB ID 6UAS

• GH128 Sorangium cellulosumendo-β-1,3-glucanase PDB ID 6UAX

• GH128 Lentinula edodesendo-β-1,3-glucanase PDB ID 6UB2
• GH128 Aureobasidium namibiaeexo-β-1,3-glucanase PDB ID 6UB8
• GH128 Aureobasidium namibiaeexo-β-1,3-glucanase, in complex with laminaritriose PDB ID 6UAB
• GH128 Aureobasidium namibiaeexo-β-1,3-glucanase, with laminaribiose at the surface-binding site PDB ID 6UBB
• GH128 Cryptococcus neoformansoligosaccharide-binding protein PDB ID 6UBC

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1. Gilbert HJ, Stålbrand H, and Brumer H. (2008). How the walls come crumbling down: recent structural biochemistry of plant polysaccharide degradation. Curr Opin Plant Biol. 2008;11(3):338-48. DOI:10.1016/j.pbi.2008.03.004 |