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Difference between revisions of "User:Stefan Janecek"
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Revision as of 08:53, 25 December 2011
He is a group leader heading the Laboratory of Protein Evolution.
He is most interested in the enzymes and proteins from the alpha-amylase family - the clan GH-H of glycoside hydrolase families GH13, GH70 and GH77 as well as the family GH57, especially in their evolution as well as their structure-function and structure-stability relationships. In addition, he is also very interested in bioinformatics studies of starch-binding domains that currently involve ten CAZy CBM families: CBM20, 21, 25, 26, 34, 41, 45, 48, 53 and 58.
Stefan works as a protein bioinfomatician, being engaged especially in the in silico studies. In his close collaboration with experimentalists, they have three amylolytic enzymes used as experimental models: (i) GH13 alpha-amylase from Thermococcus hydrothermalis; (ii) GH57 amylopullulanase from Thermococcus hydrothermalis; and (iii) GH77 amylomaltase from Borrelia burgdorferi. The experimental work is focused on protein design of these enzymes based on bioinformatics analyses.
Stefan is founder and main organiser of the international symposia on the alpha-amylase enzyme family - ALAMYs.
He is also the Managing Editor of the journal Biologia, section Cellular and Molecular Biology.