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Carbohydrate Esterase Family 6

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Carbohydrate Esterase Family CE6
Fold ( α / β / α)-sandwich
Mechanism retaining/inverting
Active site residues known/not known
CAZy DB link
http://www.cazy.org/CE6.html


Substrate specificities

Carbohydrate esterase family 6 (CE6) comprises only acetylxylan esterases (EC 3.1.1.72) - an activity also found in families CE2, CE3, CE4, CE5, CE7, and CE12 [1].

Kinetics and Mechanism

CE6 acetyl xylan esterases target the 2-, 3- or 2,3-linked O-acetyl substituents on the β-1,4-linked xylopyranosyl moieties that comprise the xylan backbone.

Catalytic Residues

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Three-dimensional structures

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Family Firsts

First stereochemistry determination
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First catalytic nucleophile identification
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First general acid/base residue identification
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First 3-D structure
Arabidopsis thaliana apo acetyl xylan esterase in 2005 PDB ID 2APJ [2].

References

  1. Cantarel BL, Coutinho PM, Rancurel C, Bernard T, Lombard V, and Henrissat B. (2009). The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics. Nucleic Acids Res. 2009;37(Database issue):D233-8. DOI:10.1093/nar/gkn663 | PubMed ID:18838391 [Cantarel2009]
  2. Bitto E, Bingman CA, McCoy JG, Allard ST, Wesenberg GE, and Phillips GN Jr. (2005). The structure at 1.6 Angstroms resolution of the protein product of the At4g34215 gene from Arabidopsis thaliana. Acta Crystallogr D Biol Crystallogr. 2005;61(Pt 12):1655-61. DOI:10.1107/S0907444905034074 | PubMed ID:16301800 [Bitto2005]
  3. Davies, G.J. and Sinnott, M.L. (2008) Sorting the diverse: the sequence-based classifications of carbohydrate-active enzymes. The Biochemist, vol. 30, no. 4., pp. 26-32. Download PDF version.

    [DaviesSinnott2008]

All Medline abstracts: PubMed