CAZypedia celebrates the life of Senior Curator Emeritus Harry Gilbert, a true giant in the field, who passed away in September 2025.


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Difference between revisions of "Template:News"

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'''6 August 2015:'''  ''Live from the Cellulase/CAZyme GRC:''  ''CAZypedia'' marches on with the completion of the '''[[Polysaccharide Lyase Family 1]]''' today by [[Responsible Curator]] and [[Author]] '''[[User:Richard Pickersgill|Richard Pickersgill]]''', with additional editing by [[Polysaccharide Lyase Families]] coordinator '''[[User:Wade Abbott|Wade Abbott]]'''.  '''[[PL1]]''' contains pectate lyases from microbes and plants, which are key enzymes in plant cell wall remodelling/break-downThe solution of the crystal structure of a pectate lyase C from the plant pathogen ''Erwinia chrysanthemi'' was the first to reveal the parallel beta-helix as a novel protein fold that is now known to serve as the scaffold of other pectinolytic enzymes, including pectin hydrolases ([[GH28]]) and pectin methylesterases ([http://www.cazy.org/CE8.html CE8]).  ''Read more about the discovery of pectate lyases and the enzymology and crystallography of [[PL1]] [[PL1|here]].''
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'''23 January 2026:'''  ''An oldie, but a goodie:''  As our first page of the new year, the '''[[Glycoside Hydrolase Family 71]]''' page, written by '''[[User:Antonielle Vieira Monclaro|Antonielle Vieira Monclaro]]''', was [[Curator Approved]] by '''[[User:Johan Larsbrink|Johan Larsbrink]]''' today.  '''[[GH71]]''' is a family of mostly fungal alpha-1,3-glucanases that was established and subjected to mechanistic characterization in the early 2000sMore recently in 2025, the Yano and [[User:Johan Larsbrink|Larsbrink]] groups independently presented the first crystal structures of '''[[GH71]]''' members (from ''Schizosaccharomyces'' and ''Aspergillus'', respectively).  ''[[User:Antonielle Vieira Monclaro|Antonielle]] wrote an excellent overview of '''[[GH71]]''', which you should definitely check out '''[[GH71|here]]'''.''
 
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'''28 July 2015:''' '''''100 GH FAMILIES!!!''''' We are extremely pleased to announce that ''CAZypedia'' has reached the key milestone of 100 [[Curator Approved]] [[Glycoside Hydrolase Families|Glycoside Hydrolase Family]] pages today, thanks to the completion of the '''[[Glycoside Hydrolase Family 12]]''' page by '''[[User:Gerlind Sulzenbacher|Gerlind Sulzenbacher]]'''.  '''[[GH12]]''' is one of the classic "cellulase" families ([http://www.ncbi.nlm.nih.gov/pubmed/1886523?dopt=Abstract formerly known as cellulase family H]) defined early in the history of the CAZy classification; [[GH12]] is now known to comprise both microbial endo-glucanases and endo-xyloglucanases. The completion of this page is especially timely in advance of the upcoming [http://www.grc.org/programs.aspx?id=12846 2015 GRC on Cellulosomes, Cellulases & Other Carbohydrate Modifying Enzymes], happening next week. [[User:Gerlind Sulzenbacher|Gerlind]] performed the seminal crystallography in this family (under the mentorship of [[User:Gideon Davies|Gideon Davies]]), and we would especially like to thank her for producing an excellent summary and series of figures for the "[[Glycoside_Hydrolase_Family_12#Three-dimensional_structures|Three-dimensional structures]]" section.
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'''8 December 2025:''' ''Just in time for the holidays:'' The '''[[Glycosyltransferase Family 138]]''' page by [[Author]] '''[[User:Wei Peng|Wei Peng]]''' and [[Responsible Curator]] '''[[User:Kim Orth|Kim Orth]]''' was [[Curator Approved]] today. '''[[GT138]]''' is small family of plant-associated bacterial members.  The archetype from ''Pseudomonas syringae'', AvrB, is a rhamnosyl transferase that glycosylates the plant host protein RIN4 to effect programmed cell death (hypersensitive response).  Also notable, AvrB has an unusual protein fold among [[glycosyltransferases]], based upon a "Fido" domain. '''''[[GT138]]''' represents one of a small, but hopefully growing, number of [[Glycosyltransferases|GT]] pages in ''CAZypedia'', whose unique features you should read more about '''[[GT138|here]]'''.''
 
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'''31 October 2025:''' ''A spooktacular addition to the CAZypedia family!'' Come and say 'Boo!' to the frighteningly well written '''[[CBM13]]''' ''CAZypedia'' page.  The '''[[CBM13]]''' family is a '''[[Carbohydrate-binding_modules#Blurred Lines: CBMs, Lectins and Outliers|lectin-like CBM family]]'''. Its first characterized members were lectins, including the B chain from the highly toxic [https://en.wikipedia.org/wiki/Ricin ricin] toxin from ''Ricinus communis''. This spine tingling read was authored by '''[[User:Scott Mazurkewich|Scott Mazurkewich]]''' and '''[[User:Lauren McKee|Lauren McKee]]''' who also acted as responsible curator. ''Come and visit the scariest of ''CAZypedia'' CBM pages, '''[[CBM13|here!]]'''...  if you dare...'' 
''The [[Board of Curators]] would also like to take the opportunity of this key milestone to express our sincere gratitude to our many expert [[:Category:Contributors|Contributors]] for their time and dedication to building ''CAZypedia'' as a community-based resource [[:CAZypedia:History|over the past 8 years]]. In addition to the [[Glycoside Hydrolase Families|100 Curator Approved GH pages]], ''CAZypedia'' also currently contains [[Polysaccharide_Lyase_Families|5 PL Family pages]], [[Auxiliary Activity Families|2 AA Family pages]], [[Glycosyltransferase Families|2 GT Family pages]], [[Carbohydrate Binding Module Families|10 CBM Family pages]], and [[Lexicon|22 Lexicon pages]]!''
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'''29 July 2025:'''  ''[[CBM91]] is in the news!''  The xylan binding '''[[CBM91]]''' family ''CAZypedia'' page is up and running.  Appended to mainly [[GH43]] xylanases this [[CBM91]] family drives interaction with substrate. The [[CBM91]] page was authored by '''[[User:Daichi Ito|Daichi Ito]]''' who also discovered the initial xylan-binding function which resulted in the creation of the [[CBM91]] CAZy family. ''Read up on this industrially interesting '''[[CBM91]]''' family '''[[CBM91|here]]'''.''
 
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Latest revision as of 07:14, 26 January 2026

23 January 2026: An oldie, but a goodie: As our first page of the new year, the Glycoside Hydrolase Family 71 page, written by Antonielle Vieira Monclaro, was Curator Approved by Johan Larsbrink today. GH71 is a family of mostly fungal alpha-1,3-glucanases that was established and subjected to mechanistic characterization in the early 2000s. More recently in 2025, the Yano and Larsbrink groups independently presented the first crystal structures of GH71 members (from Schizosaccharomyces and Aspergillus, respectively). Antonielle wrote an excellent overview of GH71, which you should definitely check out here.


8 December 2025: Just in time for the holidays: The Glycosyltransferase Family 138 page by Author Wei Peng and Responsible Curator Kim Orth was Curator Approved today. GT138 is small family of plant-associated bacterial members. The archetype from Pseudomonas syringae, AvrB, is a rhamnosyl transferase that glycosylates the plant host protein RIN4 to effect programmed cell death (hypersensitive response). Also notable, AvrB has an unusual protein fold among glycosyltransferases, based upon a "Fido" domain. GT138 represents one of a small, but hopefully growing, number of GT pages in CAZypedia, whose unique features you should read more about here.


31 October 2025: A spooktacular addition to the CAZypedia family! Come and say 'Boo!' to the frighteningly well written CBM13 CAZypedia page. The CBM13 family is a lectin-like CBM family. Its first characterized members were lectins, including the B chain from the highly toxic ricin toxin from Ricinus communis. This spine tingling read was authored by Scott Mazurkewich and Lauren McKee who also acted as responsible curator. Come and visit the scariest of CAZypedia CBM pages, here!... if you dare...


29 July 2025: CBM91 is in the news! The xylan binding CBM91 family CAZypedia page is up and running. Appended to mainly GH43 xylanases this CBM91 family drives interaction with substrate. The CBM91 page was authored by Daichi Ito who also discovered the initial xylan-binding function which resulted in the creation of the CBM91 CAZy family. Read up on this industrially interesting CBM91 family here.