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| − | '''November 23, 2018:''' ''Welcome to the CAZypedia fold [[CBM49]]!'' The crystalline cellulose-binding [[CBM49]] CAZypedia page was authored by '''[[User:Breeanna Urbanowicz|Breeanna Urbanowicz]]''' and '''[[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]]'''. '''[[User:Breeanna Urbanowicz|Breeanna Urbanowicz]]''' also acted as responsible curator. There is experimental evidence that rice[[CBM49]] is cleaved post-translationally in vivo which probably plays an important role in plant growth. Find out more about the interesting family 49 CBMs '''[[CBM49|here]]'''. | + | '''23 January 2026:''' ''An oldie, but a goodie:'' As our first page of the new year, the '''[[Glycoside Hydrolase Family 71]]''' page, written by '''[[User:Antonielle Vieira Monclaro|Antonielle Vieira Monclaro]]''', was [[Curator Approved]] by '''[[User:Johan Larsbrink|Johan Larsbrink]]''' today. '''[[GH71]]''' is a family of mostly fungal alpha-1,3-glucanases that was established and subjected to mechanistic characterization in the early 2000s. More recently in 2025, the Yano and [[User:Johan Larsbrink|Larsbrink]] groups independently presented the first crystal structures of '''[[GH71]]''' members (from ''Schizosaccharomyces'' and ''Aspergillus'', respectively). ''[[User:Antonielle Vieira Monclaro|Antonielle]] wrote an excellent overview of '''[[GH71]]''', which you should definitely check out '''[[GH71|here]]'''.'' |
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| − | '''October 11, 2018:''' ''Fall ushers in a new CAZypedia CBM family page.'' The chitin-binding and lytic polysaccharide monooxygenase associated [[CBM73]] family is described in detail. '''[[User:Zarah Forsberg|Zarah Forsberg]]''' authored the page and '''[[User:Gustav Vaaje-Kolstad|Gustav Vaaje-Kolstad]]''' acted as responsible curator. Learn more about the [[CBM73]] family on its CAZypedia [[CBM73|page]]. | + | '''8 December 2025:''' ''Just in time for the holidays:'' The '''[[Glycosyltransferase Family 138]]''' page by [[Author]] '''[[User:Wei Peng|Wei Peng]]''' and [[Responsible Curator]] '''[[User:Kim Orth|Kim Orth]]''' was [[Curator Approved]] today. '''[[GT138]]''' is small family of plant-associated bacterial members. The archetype from ''Pseudomonas syringae'', AvrB, is a rhamnosyl transferase that glycosylates the plant host protein RIN4 to effect programmed cell death (hypersensitive response). Also notable, AvrB has an unusual protein fold among [[glycosyltransferases]], based upon a "Fido" domain. '''''[[GT138]]''' represents one of a small, but hopefully growing, number of [[Glycosyltransferases|GT]] pages in ''CAZypedia'', whose unique features you should read more about '''[[GT138|here]]'''.'' |
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| − | '''September 24, 2018:''' ''Revenge of the Ruminococci Part Deux.'' Two more CBM families from Ruminococcal bacteria are ready for reading. The [[CBM79]] and [[CBM80]] CAZypedia pages were authored by '''[[User:Immacolata Venditto|Immacolata Venditto]]''' and '''[[User:Harry Gilbert|Harry Gilbert]]''' acted as responsible curator. These CBMs are important for enzyme targeting but also for targeting the entire cellulosome complex to substrate. Information on the [[CBM79]] and [[CBM80]] families can be found on their respective CAZypedia pages. | + | '''31 October 2025:''' ''A spooktacular addition to the CAZypedia family!'' Come and say 'Boo!' to the frighteningly well written '''[[CBM13]]''' ''CAZypedia'' page. The '''[[CBM13]]''' family is a '''[[Carbohydrate-binding_modules#Blurred Lines: CBMs, Lectins and Outliers|lectin-like CBM family]]'''. Its first characterized members were lectins, including the B chain from the highly toxic [https://en.wikipedia.org/wiki/Ricin ricin] toxin from ''Ricinus communis''. This spine tingling read was authored by '''[[User:Scott Mazurkewich|Scott Mazurkewich]]''' and '''[[User:Lauren McKee|Lauren McKee]]''' who also acted as responsible curator. ''Come and visit the scariest of ''CAZypedia'' CBM pages, '''[[CBM13|here!]]'''... if you dare...'' |
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| − | '''July 3, 2018:''' ''Revenge of the Ruminococci.'' Three CBM families containing characterized CBM members from Ruminococcal bacteria are now on-line in CAZypedia; two of these families contain uniquely Ruminococcal CBMs. '''[[User:Ana Luis|Ana Luis]]''' authored the pages (in one fell swoop) and '''[[User:Harry Gilbert|Harry Gilbert]]''' acted as responsible curator. Descriptions of families '''[[CBM75]]''', '''[[CBM76]]''' and '''[[CBM77]]''' can be found on their respective CAZypedia pages. | + | '''29 July 2025:''' ''[[CBM91]] is in the news!'' The xylan binding '''[[CBM91]]''' family ''CAZypedia'' page is up and running. Appended to mainly [[GH43]] xylanases this [[CBM91]] family drives interaction with substrate. The [[CBM91]] page was authored by '''[[User:Daichi Ito|Daichi Ito]]''' who also discovered the initial xylan-binding function which resulted in the creation of the [[CBM91]] CAZy family. ''Read up on this industrially interesting '''[[CBM91]]''' family '''[[CBM91|here]]'''.'' |
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| − | '''June 4, 2018:''' ''When two worlds collide.'' The '''[[CBM81]]''' family has an interesting binding mechanism, mixing characteristics of both [[Carbohydrate-binding_modules#Types|type A]] and [[Carbohydrate-binding_modules#Types|type B]] CBMs. The binding is enthalpically driven to soluble ligands, so by definition this is a [[Carbohydrate-binding_modules#Types|type B]] interaction; however, the CBM binding face resembles the flat face of [[Carbohydrate-binding_modules#Types|type A]] (crystalline-polysaccharide binding) CBMs. '''[[User: Marcelo Liberato|Marcelo Liberato]]''' [[author]]ed the [[CBM81]] page and '''[[User: Fabio Squina|Fabio Squina]]''' acted as the [[Responsible Curator]]. Find out more about the unusual family 81 CBMs '''[[CBM81|here]]'''.
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| − | '''25 May 2018:''' ''The almost exclusive expansin associated [[CBM63]] family is on-line.'' An interesting function is described as a bacterial [[CBM63]] targets expansin to biomechanical hotspots in the ''Arabidopsis'' cell wall, where cell wall loosening occurs. The page was authored by '''[[User: Will Chase|Will Chase]]''' and '''[[User: Daniel Cosgrove|Daniel Cosgrove]]''' with '''[[User: Daniel Cosgrove|Daniel Cosgrove]]''' acting as responsible curator. Learn more about this expansin family CBM [[CBM63|here]].
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| − | '''4 May 2018:''' ''CAZypedia's first non-LPMO Auxiliary Activity Family page!'' Today [[Responsible Curator]] '''[[User:Roland Ludwig|Roland Ludwig]]''' [[Curator Approved|approved]] '''[[User:Daniel Kracher|Daniel Kracher's]]''' and his expansive '''[[Auxiliary Activity Family 3]]''' page. '''[[AA3]]''' comprises a number of FAD-dependent redox enzymes including cellobiose dehydrogenase, aryl alcohol oxidase/dehydrogenases, glucose oxidases and glucose dehydrogenases, pyranose dehydrogenase, alcohol oxidase, and pyranose oxidase across four subfamilies. '''''[[User:Roland Ludwig|Roland]]''' and '''[[User:Daniel Kracher|Daniel]]''' have done a monumental job in succinctly capturing the diversity of this family, which you can read about [[Auxiliary Activity Family 3|here]].''
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| − | '''2 May 2018:''' ''The [[CBM65]] page has been added to the CAZypedia fold.'' This is a small CAZy family with two currently characterized members from an anaerobic cellulolytic ruminal bacterium. The two [[CBM65]] members bind various beta-glucans and play an important role in enhancing enzymatic activity on substrate. The page was authored by '''[[User:Ana Luis|Ana Luis]]''' and '''[[User:Harry Gilbert|Harry Gilbert]]''' acted as responsible curator. ''Learn more about this CBM family [[CBM65|here]].''
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| − | '''1 March 2018:''' The shortest month of the year saw four '''[[CBM]]''' families reach '''[[Curator Approved]]''' status, including two early members. '''[[User:Harry Gilbert|Harry Gilbert]]''' with input from '''[[User:Ed Bayer|Ed Bayer]]''', who also acted as '''[[Responsible Curator]]''', authored the cellulose-binding '''[[CBM3]]''' page. '''[[User:Harry Gilbert|Harry Gilbert]]''' and '''[[User:Claire Dumon|Claire Dumon]]''' both contributed to the xylan and glucan-binding '''[[CBM4]]''' page. The xylan-binding '''[[CBM22]]''' page was taken on by '''[[User:Harry Gilbert|Harry Gilbert]]''' solo. Finally, the cellulose-binding '''[[CBM78]]''' family was authored by '''[[User:Immacolata Venditto|Immacolata Venditto]]''', with '''[[User:Harry Gilbert|Harry Gilbert]]''' acting as '''[[Responsible Curator]]'''. ''Learn more about each of these families on [[Carbohydrate Binding Module Families|their respective pages]].''
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| − | '''15 February 2018:''' ''More on pectin, and also arabinan:'' '''[[User:Jonathon Briggs|Jonathon Briggs]]''' recently completed the '''[[Glycoside Hydrolase Family 147]]''' and '''[[Glycoside Hydrolase Family 146]]''' pages, which are involved in the utilization of pectin and galactan, respectively, by human gut Bacteroidetes. Both pages were upgraded to [[Curator Approved]] status today by [[Responsible Curator]] '''[[User:Harry Gilbert|Harry Gilbert]]'''. ''Learn more about these newly described families at [[GH146]] and [[GH147]].''
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| − | '''13 February 2018:''' ''The intricacies of pectin deconstruction:'' Rhamnogalacturonan II (RGII) represents the most structurally complex plant cell wall polysaccharide currently known, the complete saccharification of which requires a battery of CAZymes. Under the guidance of [[Responsible Curator]] '''[[User:Harry Gilbert|Harry Gilbert]]''', four new GH pages related to RGII deconstruction were [[Curator Approved]] today. Special thanks go to [[Author]]s '''[[User:Ana Luis|Ana Luis]]''' ('''[[GH106]]''', '''[[GH139]]''', and '''[[GH141]]''') and '''[[User:Didier Ndeh|Didier Ndeh]]''' ('''[[GH138]]''') for their hard work in putting these pages together. ''Learn more about the individual, specific contributions of each of these families (three of which have been recently uncovered) to microbial RGII utilization on their respective pages.''
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23 January 2026: An oldie, but a goodie: As our first page of the new year, the Glycoside Hydrolase Family 71 page, written by Antonielle Vieira Monclaro, was Curator Approved by Johan Larsbrink today. GH71 is a family of mostly fungal alpha-1,3-glucanases that was established and subjected to mechanistic characterization in the early 2000s. More recently in 2025, the Yano and Larsbrink groups independently presented the first crystal structures of GH71 members (from Schizosaccharomyces and Aspergillus, respectively). Antonielle wrote an excellent overview of GH71, which you should definitely check out here.
8 December 2025: Just in time for the holidays: The Glycosyltransferase Family 138 page by Author Wei Peng and Responsible Curator Kim Orth was Curator Approved today. GT138 is small family of plant-associated bacterial members. The archetype from Pseudomonas syringae, AvrB, is a rhamnosyl transferase that glycosylates the plant host protein RIN4 to effect programmed cell death (hypersensitive response). Also notable, AvrB has an unusual protein fold among glycosyltransferases, based upon a "Fido" domain. GT138 represents one of a small, but hopefully growing, number of GT pages in CAZypedia, whose unique features you should read more about here.
31 October 2025: A spooktacular addition to the CAZypedia family! Come and say 'Boo!' to the frighteningly well written CBM13 CAZypedia page. The CBM13 family is a lectin-like CBM family. Its first characterized members were lectins, including the B chain from the highly toxic ricin toxin from Ricinus communis. This spine tingling read was authored by Scott Mazurkewich and Lauren McKee who also acted as responsible curator. Come and visit the scariest of CAZypedia CBM pages, here!... if you dare...
29 July 2025: CBM91 is in the news! The xylan binding CBM91 family CAZypedia page is up and running. Appended to mainly GH43 xylanases this CBM91 family drives interaction with substrate. The CBM91 page was authored by Daichi Ito who also discovered the initial xylan-binding function which resulted in the creation of the CBM91 CAZy family. Read up on this industrially interesting CBM91 family here.