|
|
| (365 intermediate revisions by 3 users not shown) |
| Line 1: |
Line 1: |
| − | '''19 March 2015:''' ''Closing-in on 100:'' ''CAZypedia'' is on the way to an important milestone, our 100th [[Curator Approved]] [[Glycoside Hydrolase Families|Glycoside Hydrolase Family]] page. Thanks go to our colleagues '''[[User:Tomomi Sumida|Tomomi Sumida]]''', who completed the '''[[Glycoside Hydrolase Family 123]]''' page on March 17, and '''[[User:Wataru Saburi|Wataru Saburi]]''' and '''[[User:Haruhide Mori|Haruhide Mori]]''', who completed the '''[[Glycoside Hydrolase Family 130]]''' page on March 18. Members of these two [[Glycoside Hydrolase Families|GH families]] represent very distinct structures, specificities mechanisms, which you can learn more about on their individual pages. The high GH family numbers of these two groups reflect their comparatively recent addition to the [http://www.cazy.org/Glycoside-Hydrolases.html CAZy Database] and highlight the continuing evolution of the field through the discovery of new CAZymes. | + | '''31 October 2025:''' ''A spooktacular addition to the CAZypedia family!'' Come and say 'Boo!' to the frighteningly well written '''[[CBM13]]''' ''CAZypedia'' page. The '''[[CBM13]]''' family is a '''[[Carbohydrate-binding_modules#Blurred Lines: CBMs, Lectins and Outliers|lectin-like CBM family]]'''. Its first characterized members were lectins, including the B chain from the highly toxic [https://en.wikipedia.org/wiki/Ricin ricin] toxin from ''Ricinus communis''. This spine tingling read was authored by '''[[User:Scott Mazurkewich|Scott Mazurkewich]]''' and '''[[User:Lauren McKee|Lauren McKee]]''' who also acted as responsible curator. ''Come and visit the scariest of ''CAZypedia'' CBM pages, '''[[CBM13|here!]]'''... if you dare...'' |
| | ---- | | ---- |
| − | '''23 February 2015:''' ''The sites that bind:'' '''[[User:Birte Svensson|Birte Svensson]]''' and '''[[User:Darrell Cockburn|Darrell Cockburn]]''' have completed the '''[[Surface Binding Site]]''' page within the ''CAZypedia'' [[Lexicon]]. Surface binding sites are substrate-binding regions found on the catalytic domain of carbohydrate-active enzymes and appear to play complementary roles to carbohydrate-binding modules in facilitating the action of polysaccharide-degrading glycoside hydrolases. ''Read more about these intriguing features and their distribution among CAZymes [[Surface Binding Site|here]].'' | + | '''29 July 2025:''' ''[[CBM91]] is in the news!'' The xylan binding '''[[CBM91]]''' family ''CAZypedia'' page is up and running. Appended to mainly [[GH43]] xylanases this [[CBM91]] family drives interaction with substrate. The [[CBM91]] page was authored by '''[[User:Daichi Ito|Daichi Ito]]''' who also discovered the initial xylan-binding function which resulted in the creation of the [[CBM91]] CAZy family. ''Read up on this industrially interesting '''[[CBM91]]''' family '''[[CBM91|here]]'''.'' |
| − | ----
| |
| − | '''20 February 2015:''' ''One for the Gals:'' '''[[User:Harry Gilbert|Harry Gilbert]]''' has given the '''[[Carbohydrate Binding Module Family 62]]''' page, which was authored by '''[[User:Cedric Montanier|Cedric Montanier]]''', [[Curator Approved]] status today. Functional and structural characterization of the archetypal '''[[CBM62]]''' member from a ''Clostridium thermocellum'' xylanase revealed a strong affinity for galactose residues of either anomeric configuration on plant polysaccharides. Although the precise roles of this and other '''[[CBM62]]''' members remains somewhat ambiguous, it is clear that these modules are relevant to the targeting of enzymes to the composite plant cell wall. ''Read more about the work of the all-star team that put [[CBM62]] on the map (of CAZy families), [[Carbohydrate Binding Module Family 62|here]].''
| |
| − | ----
| |
| − | '''19 January 2015:''' ''Still in the high 70's today:'' '''[[User:Zui Fujimoto|Zui Fujimoto]]''' brought the '''[[Glycoside Hydrolase Family 78]]''' page up to [[Curator Approved]] status today, making it ''CAZypedia's'' 97th approved GH page. '''[[GH78]]''' is a family of archaeal, bacterial, and fungal alpha-L-rhamnosidases that cleave diverse flavonoid glycosides, polysaccharides, glycoproteins, and glycolipids from plants. ''Read more on these ecologically relevant enzymes [[Glycoside Hydrolase Family 78|here]].''
| |
| − | ----
| |
| − | '''7 January 2015:''' ''Love your guts:'' ''CAZypedia'' is ringing in the new year with a new '''[[Glycoside Hydrolase Family 76]]''' page by '''[[User:Spencer Williams|Spencer Williams]]'''. '''[[GH76]]''' contains endo-acting α-mannanases, including members from the human gut bacterium ''Bacteroides thetaiotaomicron'' that enable us to degrade yeast mannans in our diet. A very recent publication in ''Nature'', notably involving ''CAZypedia'' contributors '''[[User:Michael Suits|Michael Suits]]''', '''[[User:Al Boraston|Al Boraston]]''', '''[[User:Spencer Williams|Spencer Williams]]''', '''[[User:Gideon Davies|Gideon Davies]]''', '''[[User:Wade Abbott|Wade Abbott]]''', and '''[[User:Harry Gilbert|Harry Gilbert]]''', has recently shed new light on the structure, mechanism, and biological function of these enzymes. ''Read more [[Glycoside Hydrolase Family 76|here]]!''
| |
| | ---- | | ---- |
31 October 2025: A spooktacular addition to the CAZypedia family! Come and say 'Boo!' to the frighteningly well written CBM13 CAZypedia page. The CBM13 family is a lectin-like CBM family. Its first characterized members were lectins, including the B chain from the highly toxic ricin toxin from Ricinus communis. This spine tingling read was authored by Scott Mazurkewich and Lauren McKee who also acted as responsible curator. Come and visit the scariest of CAZypedia CBM pages, here!... if you dare...
29 July 2025: CBM91 is in the news! The xylan binding CBM91 family CAZypedia page is up and running. Appended to mainly GH43 xylanases this CBM91 family drives interaction with substrate. The CBM91 page was authored by Daichi Ito who also discovered the initial xylan-binding function which resulted in the creation of the CBM91 CAZy family. Read up on this industrially interesting CBM91 family here.